Neutrophil mobility during anaesthesia in children. A trial of ascorbate premedication.

Abstract:

:In 20 healthy children undergoing elective surgery, mobility of neutrophils, both unstimulated and stimulated by endotoxin, was studied using a millipore filter system with microscopic determination of leading front migration. Paired samples were incubated with 10(-2) mol l-1 calcium ascorbate and ten children also received 10 mg kg-1 ascorbic acid before premedication. Stimulation of mobility was reduced after the opioid premedication (P less than 0.05) in the ascorbate group only, but not significantly during anaesthesia and surgery. A few individuals showed persisting abnormally low values. No effect of ascorbate in vivo or in vitro was demonstrated. There were no infections.

authors

Charlton AJ,Harvey BA,Hatch DJ,Soothill JF

doi

10.1111/j.1399-6576.1987.tb02580.x

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

343-6

issue

4

eissn

0001-5172

issn

1399-6576

journal_volume

31

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章,随机对照试验

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    pub_type: 杂志文章

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    pub_type: 临床试验,杂志文章

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