Cervical vasopressin compared with no premedication and blood loss during vaginal hysterectomy: a randomized controlled trial.


OBJECTIVE:To compare blood loss, operative time, postoperative pain medication requirements, and complication rates in patients undergoing vaginal hysterectomy who were randomly assigned to receive preoperative intracervical vasopressin or no intracervical injection. METHODS:Fifty-eight women undergoing vaginal hysterectomy were randomly allocated to receive either eight units of vasopressin intracervically or nothing preoperative from January 2004 to January 2005. A researcher blinded to the study group determined blood loss. The surgeries were performed using uniform steps by senior residents under the direction of two attending surgeons. Multiple preoperative and postoperative values were evaluated, including time to specific points in surgery and use of postoperative pain medication. Independent sample t tests, Fisher exact test, and Pearson chi tests were used to analyze the data. RESULTS:The two groups were similar in terms of age, weight, parity, and ethnicity. There was also no difference in indication for surgery or estimated uterine size. The vasopressin group lost significantly less blood (145.3 mL compared with 266.4 mL control; P=.022). There was a significant difference in the increase in mean blood pressure at 5 minutes after injection (10.4 for the vasopressin group compared with. 2.5 for the control group, P=.043). There was no significant difference in immediate recovery room morphine requirements, but patient-controlled anesthesia usage was significantly higher in the vasopressin group. CONCLUSION:The preoperative injection of intracervical vasopressin leads to decreased blood loss during vaginal hysterectomy. There was, however, a significant increase in postoperative morphine use in patients receiving vasopressin. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov, www.clinicaltrials.gov, NCT00799292 LEVEL OF EVIDENCE:I.


Obstet Gynecol


Ascher-Walsh CJ,Capes T,Smith J,Michels A




Has Abstract


2009-02-01 00:00:00




2 Pt 1










  • Plasma homocysteine levels elevated and inversely related to insulin sensitivity in preeclampsia.

    abstract:OBJECTIVE:To study the plasma levels of homocysteine in preeclampsia and relate them to insulin sensitivity. METHODS:In association with a 3-hour intravenous glucose-tolerance test (glucose 0.3 g/kg at 0 and 0.03 IU insulin 20 minutes later), we measured plasma levels of homocysteine, vitamin B12, and folic acid in 22...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Laivuori H,Kaaja R,Turpeinen U,Viinikka L,Ylikorkala O

    更新日期:1999-04-01 00:00:00

  • Letrozole Compared With Clomiphene Citrate for Unexplained Infertility: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVE:To estimate the clinical effectiveness, as determined by positive pregnancy test, of letrozole compared with clomiphene citrate for ovarian stimulation in patients with unexplained infertility. DATA SOURCES:We conducted a systematic review and meta-analysis of data from electronic databases including Ovid-ME...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,meta分析


    authors: Eskew AM,Bedrick BS,Hardi A,Stoll CRT,Colditz GA,Tuuli MG,Jungheim ES

    更新日期:2019-03-01 00:00:00

  • Pelvic mass presenting as meralgia paresthetica.

    abstract::A 40-year-old woman presented to her gynecologist with an apparent unilateral neuropathy of the lateral cutaneous femoral nerve of the thigh (meralgia paresthetica). On examination, the sensory disturbance extended outside the usual distribution of the lateral femoral cutaneous nerve, suggesting a more proximal lumbar...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Suber DA,Massey EW

    更新日期:1979-02-01 00:00:00

  • Elevated maternal serum alpha-fetoprotein with normal ultrasound: is amniocentesis always appropriate? A review of 26,069 screened patients.

    abstract::We reviewed our experience with a policy of revising the estimated probability of an open neural tube defect for those cases in which maternal serum alpha-fetoprotein (MSAFP) was elevated and the ultrasound examination was normal. Assuming a sensitivity for the ultrasound diagnosis of neural tube defects of 90%, the r...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Richards DS,Seeds JW,Katz VL,Lingley LH,Albright SG,Cefalo RC

    更新日期:1988-02-01 00:00:00

  • Magnetic resonance imaging and 3-dimensional analysis of external anal sphincter anatomy.

    abstract:OBJECTIVE:To use magnetic resonance images of living women and 3-dimensional modeling software to identify the component parts and characteristic features of the external anal sphincter (EAS) that have visible separation or varying origins and insertions. METHODS:Detailed structural analysis of anal sphincter anatomy ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hsu Y,Fenner DE,Weadock WJ,DeLancey JO

    更新日期:2005-12-01 00:00:00

  • S.O.S! I'm short of breath!

    abstract:BACKGROUND:There are various causes of shortness of breath in a young, pregnant woman. The importance of entertaining a broad differential diagnosis is highlighted in this case. CASE:A young, pregnant African-American woman presented in her third trimester with acute onset of shortness of breath. A team approach by di...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Uppalapati R

    更新日期:2007-06-01 00:00:00

  • Intravenous leiomyomatosis with cardiac extension: successful surgical management and histopathologic study.

    abstract::A case of intravenous leiomyomatosis with cardiac extension was treated successfully with a two-stage operation: resection of the intracardiac and intracaval mass for the first stage and total hysterectomy with bilateral salpingo-oophorectomy for the second. Tumors were located either within or in continuity to dilate...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Suginami H,Kaura R,Ochi H,Matsuura S

    更新日期:1990-09-01 00:00:00

  • Fetal activity acceleration determination for the evaluation of fetal reserve.

    abstract::Fetal activity acceleration determination (FAD) was performed 462 times on a total of 410 patients for the evaluation of fetal reserve. Simultaneous oxytocin challenge test (OCT) was performed 324 times to evaluate the correlation between the two tests. In 308 instances, FAD was positive and OCT was either negative or...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Lee CY,Di Loreto PC,Logrand B

    更新日期:1976-07-01 00:00:00

  • The relationship between pregnancy intendedness and physical violence in mothers of newborns. The PRAMS Working Group.

    abstract:OBJECTIVE:To determine if pregnancy intendedness is associated with physical violence, and to identify factors that modify this association. METHODS:Three to 6 months after delivery, we mailed a questionnaire to a population-based sample of 12,612 mothers of infants born during 1990 and 1991 in four states. We used mu...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Gazmararian JA,Adams MM,Saltzman LE,Johnson CH,Bruce FC,Marks JS,Zahniser SC

    更新日期:1995-06-01 00:00:00

  • The impact of National Health Service Corps physicians in the lowering perinatal mortality rate in Dade County, Florida.

    abstract::In some parts of Dade County, Florida, perinatal mortality rates have revealed serious problems in the delivery of health care to poor pregnant women. From 1982-1985, the reported perinatal mortality rates varied from 32-36 per 1000 live births, more than double the national average. Under the leadership of the Primar...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,收录出版


    authors: Nguyen HN,O'Sullivan MJ,Fournier AM

    更新日期:1991-09-01 00:00:00

  • Preterm premature rupture of membranes and the rate of neonatal sepsis after two courses of antenatal corticosteroids.

    abstract:OBJECTIVE:To evaluate whether a second antenatal corticosteroid course is associated with an increased risk of neonatal sepsis after preterm premature rupture of membranes (PROM). METHODS:This secondary analysis is a cohort study with data from the Maternal-Fetal Medicine Units study on magnesium for neuroprotection. ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Gyamfi-Bannerman C,Son M

    更新日期:2014-11-01 00:00:00

  • Diagnosis of a supernumerary ovary with human chorionic gonadotropin.

    abstract::The preoperative diagnosis of ectopic ovarian tissue has been reported only once in the literature. In the present case, differential ovarian and adrenal testing was used to diagnose and aberrant ovarian source of persistently elevated plasma estrogen in a patient who had undergone bilateral oophorectomy and adrenalec...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Kosasa TS,Griffiths CT,Shane JM,Leventhal JM,Naftolin F

    更新日期:1976-02-01 00:00:00

  • Impact of increased access to emergency contraceptive pills: a randomized controlled trial.

    abstract:OBJECTIVE:To assess how a strategy to maximize access to emergency contraceptive pills would affect rates of pregnancy and sexually transmitted infections. METHODS:Sexually active women, 14-24 years old, were randomly assigned to two methods of access to emergency contraceptive pills: increased access (two packages of...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Raymond EG,Stewart F,Weaver M,Monteith C,Van Der Pol B

    更新日期:2006-11-01 00:00:00

  • Comparing perinatal mortality.

    abstract::Comparisons of perinatal outcome data among regions or hospitals can be misleading if the risk status of the population served is not considered. Data are presented from two large perinatal centers (Medical Center Hospital in San Antonio, Texas, and University of Iowa Hospitals in Iowa City, Iowa), which report substa...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hein HA,Lathrop SS,Papke KR

    更新日期:1985-09-01 00:00:00

  • Antepartum external cephalic version under tocolysis.

    abstract::Reported are 172 patients considered for external cephalic version at gestational age greater than 37 weeks. Their outcome was compared with 40 similar patients in whom external version was not attempted. One hundred fifty-eight patients had attempted version, and success was achieved in 122 (77%). Intrapartum vertex ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Dyson DC,Ferguson JE 2nd,Hensleigh P

    更新日期:1986-01-01 00:00:00

  • Synchronous primary ovarian and endometrial cancers: a population-based assessment of survival.

    abstract:OBJECTIVE:To estimate the occurrence of synchronous epithelial ovarian and endometrial cancers among ovarian cancer patients and to assess survival of women with synchronous cancers. METHODS:Synchronous ovarian and endometrial cases were identified using data from the Surveillance, Epidemiology, and End Results Progra...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Williams MG,Bandera EV,Demissie K,Rodríguez-Rodríguez L

    更新日期:2009-04-01 00:00:00

  • Instagram Users' Experiences of Miscarriage.

    abstract:OBJECTIVE:To explore the shared experiences of miscarriage using a qualitative analysis of social media posts on Instagram. METHODS:We performed this qualitative study by collecting text, photos, hashtags, and emoji from 200 Instagram posts on five arbitrarily selected days in 2019. Key eligibility criteria included p...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Mercier RJ,Senter K,Webster R,Henderson Riley A

    更新日期:2020-01-01 00:00:00

  • Preeclampsia and Long-term Renal Function in Women Who Underwent Kidney Transplantation.

    abstract:OBJECTIVE:Preeclampsia often complicates pregnancies after maternal kidney transplantation. We aimed to assess whether preeclampsia is associated with kidney function decline either during the pregnancy or in the long term. METHODS:We performed an international multicenter retrospective cohort study. Renal function at...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究


    authors: Vannevel V,Claes K,Baud D,Vial Y,Golshayan D,Yoon EW,Hodges R,Le Nepveu A,Kerr PG,Kennedy C,Higgins M,Resch E,Klaritsch P,Van Mieghem T

    更新日期:2018-01-01 00:00:00

  • Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease.

    abstract:OBJECTIVE:To determine whether the prevalence of normal endometrial cells in Papanicolaou smears of women with and those without endometrial carcinoma or hyperplasia differs significantly. METHODS:Papanicolaou smears of women with biopsy-proved endometrial hyperplasia or carcinoma diagnosed between 1990 and 1998 were ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Gomez-Fernandez CR,Ganjei-Azar P,Behshid K,Averette HE,Nadji M

    更新日期:2000-12-01 00:00:00

  • Association of a Biweekly Research Workgroup With Enhanced Resident Research Productivity.

    abstract::Almost all residency programs require a resident research project, yet teaching and mentoring of the required skills are often lacking. We established an every-other-week gynecologic oncology research workgroup at our institution for obstetrics and gynecology faculty, fellows, and residents with the goal of increasing...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Brackmann M,Reynolds RK,Uppal S,McLean K

    更新日期:2016-09-01 00:00:00

  • Incidence and risk factors for stroke in pregnancy and the puerperium.

    abstract:OBJECTIVE:To estimate the incidence, mortality, and risk factors for pregnancy-related stroke in the United States. METHODS:The Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality, for the years 2000-2001 was queried for International Classific...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: James AH,Bushnell CD,Jamison MG,Myers ER

    更新日期:2005-09-01 00:00:00

  • Effects of the dopamine antagonist veralipride on hot flushes and luteinizing hormone secretion in postmenopausal women.

    abstract::The effects on hot flushes of the dopamine antagonist Veralipride versus placebo were investigated in a randomized double-blind study of postmenopausal healthy women (N = 20 in each group). Cutaneous temperature recording and plasma LH pulsatility were studied in eight patients from each group. Veralipride administrat...

    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Melis GB,Gambacciani M,Cagnacci A,Paoletti AM,Mais V,Fioretti P

    更新日期:1988-11-01 00:00:00

  • Glycosylated hemoglobins in normal pregnancy: sequential changes and relation to birth weight.

    abstract::In order to evaluate changes in hemoglobin A1 levels during nondiabetic pregnancy, 19 pregnant women were followed by determination of hemoglobin A1 with a two to four week interval. There was an early decrease in the hemoglobin A1 level already between the 12th and 16th weeks of pregnancy, with a further decrease in ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Hanson U,Hagenfeldt L,Hagenfeldt K

    更新日期:1983-12-01 00:00:00

  • Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial.

    abstract:OBJECTIVE:To assess the efficacy and safety of an oral formulation of tranexamic acid for the treatment of heavy menstrual bleeding. METHODS:Adult women with heavy menstrual bleeding (mean menstrual blood loss 80 mL or more per cycle) were enrolled in a double-blind, placebo-controlled study. After two pretreatment me...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lukes AS,Moore KA,Muse KN,Gersten JK,Hecht BR,Edlund M,Richter HE,Eder SE,Attia GR,Patrick DL,Rubin A,Shangold GA

    更新日期:2010-10-01 00:00:00

  • Surgical management of acute diverticulitis in women.

    abstract::The incidence of diverticular disease of the colon has increased during the course of this century. The management of diverticulitis has changed in many centers from a conservative medical approach to a more aggressive surgical one. The surgical technique has also evolved; primary resection and anastomosis is currentl...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Raventos JM,Symmonds RE

    更新日期:1981-11-01 00:00:00

  • Bundling a pregnancy test with the Yuzpe regimen of emergency contraception.

    abstract::The recent United States Food and Drug Administration approval of a commercial kit containing the Yuzpe regimen for emergency contraception is a welcome event. Unlike emergency contraceptive pills sold in other countries, however, the United States product has a pregnancy test bundled with the pills. The test could id...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Grimes DA,Raymond EG

    更新日期:1999-09-01 00:00:00

  • Retrograde ejaculation: successful treatment with artificial insemination.

    abstract::Retrograde ejaculation is characterized by aspermia or oligospermia and results from an incompetent bladder neck, often due to a dysfunction of the internal sphincter. In almost 3 years, eight couples who suffered from infertility due to retrograde ejaculation were treated with inseminations with spermatozoa gained fr...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: van der Linden PJ,Nan PM,te Velde ER,van Kooy RJ

    更新日期:1992-01-01 00:00:00

  • Repeat measurement of cervical length after successful tocolysis.

    abstract:OBJECTIVE:To measure the ultrasonographic cervical length in undelivered women after successful tocolysis for preterm labor, and to determine whether this could improve the predictive value of cervical length measured before initiation of tocolysis on the risk of preterm delivery. METHODS:This was a prospective study ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Rozenberg P,Rudant J,Chevret S,Boulogne AI,Ville Y

    更新日期:2004-11-01 00:00:00

  • Intrauterine growth retarded infants. Correlation of gestational age with maternal factors, mode of delivery, and perinatal survival.

    abstract::Fifty-eight infants of 3332 deliveries (1.7%) were found to be growth retarded (IGR) at birth. For purposes of analysis, the infants were divided into 2 groups according to gestational age at delivery: Group I infants were delivered between 38 and 43 weeks' gestation, and Group II infants were delivered between 28 and...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Perry CP,Harris RE,DeLemos RA,Null DM Jr

    更新日期:1976-08-01 00:00:00

  • Umbilical artery regression: a rare complication of intravascular fetal transfusion.

    abstract:BACKGROUND:Intravascular fetal transfusion is an important therapeutic advance but is associated with several complications. Regression of an umbilical artery associated with transfusion is rare. CASE:A case of red blood cell alloimmunization managed by serial transfusions was complicated by functional loss of an umbi...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章


    authors: Smith JF Jr,Warner KD,Bergmann M,Pushchak MJ

    更新日期:1999-05-01 00:00:00