Abstract:
OBJECTIVES:To evaluate the relationship between contrast-enhanced (CE) ultrasound Liver Reporting and Data System (LI-RADS) classification of combined hepatocellular-cholangiocarcinoma (cHCC-CCA) and their histopathological component predominance, and to determine if the CEUS LI-RADS category can be used to predict the patient's survival after surgical resection. METHODS:Between January 2011 and December 2018, medical records and CEUS of patients with pathologically proven cHCC-CCA were studied. The predominance of hepatocellular carcinoma (HCC)/intrahepatic cholangiocarcinoma (ICC) component of cHCC-CCA was analyzed by histopathology. The proportion of HCC-predominant cHCC-CCA in different LI-RADS category was compared by using Fisher's exact test. Factors affecting tumor recurrence were analyzed by Cox proportional hazard model. Disease-free survival (DFS) was estimated by using Kaplan-Meier survival curve and compared by log-rank test. RESULTS:The study included 37 cHCC-CCA patients (33 men, 4 women; average age, 50.4 ± 11.0 years) and 37 nodules (mean diameter, 6.1 ± 3.9 cm). According to CEUS LI-RADS, 62.2% (23/37), 18.9% (7/37), and 18.9% (7/37) of cHCC-CCA were classified as LR-M, LR-5, and LR-TIV, respectively. The ratio of HCC predominance in LR-5 was 100% (10/10) vs 81.5% (22/27) in the LR-M group (p = 0.591). In our population, LR-5 patients had longer DFS than LR-M and LR-TIV patients combined (median DFS: 18.0 vs 6.4 months, p = 0.016). Multiple lesions (hazard ratio, 3.1; p = 0.007), tumor size (≥ 5 cm, hazard ratio, 4.1; p = 0.003), and CEUS LI-RADS category (LR-M and LR-TIV, hazard ratio, 4.7; p = 0.011) showed independent association with shorter DFS. CONCLUSION:cHCC-CCA characterized as LR-5 on CEUS tend to represent HCC-predominant tumors with significantly longer disease-free survival compared to cHCC-CCA categorized as LR-M and LR-TIV. KEY POINTS:• By using the American College of Radiology contrast-enhanced ultrasound Liver Imaging Reporting and Data System (CEUS LI-RADS), majority (30/37, 81.1%) of cHCC-CCA tumors were classified as LR-M or LR-TIV and only 18.9% (7/30) of cHCC-CCA were categorized as LR-5. • Patients with CEUS LR-5 cHCC-CCA had statistically significant longer disease-free time than those with LR-M and TIV cHCC-CCA (median DFS: 18.0 vs 6.4 months, p = 0.016). • Multiple lesions (hazard ratio, 3.1; p = 0.007), tumor size (≥ 5 cm, hazard ratio, 4.1; p = 0.003), and CEUS LI-RADS category (LR-M and LR-TIV, hazard ratio, 4.7; p = 0.011) showed independent association with shorter DFS.
journal_name
Eur Radioljournal_title
European radiologyauthors
Yang J,Huang JY,Chen X,Ling WW,Luo Y,Shi YJ,Liu JB,Lu Q,Lyshchik Adoi
10.1007/s00330-020-07656-1subject
Has Abstractpub_date
2021-01-25 00:00:00eissn
0938-7994issn
1432-1084pii
10.1007/s00330-020-07656-1pub_type
杂志文章abstract:OBJECTIVE:This retrospective study aims to assess the accuracy of two-phase computed tomography (CT) and transoesophageal echocardiography (TEE) for the detection of left atrial (LA) thrombus in patients with mitral stenosis (MS) and atrial fibrillation (AF), by using intraoperative findings as the reference standard. ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-2944-5
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Evaluate the performance of a robotic system for CT-guided lung biopsy in comparison to the conventional manual technique. MATERIALS AND METHODS:One hundred patients referred for CT-guided lung biopsy were randomly assigned to group A (robot-assisted procedure) or group B (conventional procedure). Size, dist...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
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abstract::The purpose of our study is to demonstrate the value of CT in the emergency department (ED) for patients with non-traumatic abdominal pain. Between August 1998 and April 1999, 536 consecutive patients with non-traumatic abdominal pain were entered into our study. Using a computer order entry system, physicians were as...
journal_title:European radiology
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abstract::The aim of this study was to assess the capability of a 3D isotropic MRI T2-weighted sequence (3D T2 ISO) in the depiction of changes of neurovascular bundles (NVBs) after bilateral nerve-sparing radical retropubic prostatectomy (RRP). Furthermore, our aim was also to introduce a new MRI classification score of the NV...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-008-1102-y
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To develop and evaluate the performance of a deep learning-based system for automatic patellar height measurements using knee radiographs. METHODS:The deep learning-based algorithm was developed with a data set consisting of 1018 left knee radiographs for the prediction of patellar height parameters, specif...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-06856-z
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abstract:OBJECTIVES:To investigate the association of chest CT findings with mortality in clinical management of older patients. METHODS:From January 21 to February 14, 2020, 98 older patients (≥ 60 years) who had undergone chest CT scans ("initial CT") on admission were enrolled. Manifestation and CT score were compared betwe...
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abstract:OBJECTIVES:Fractional flow reserve computed tomography (FFRCT) depends upon nitroglycerin (NTG) inducing maximal hyperemia. However, the impact of NTG dosages on FFRCT analysis including coronary volume-to-mass ratio (V/M) is unknown. METHODS:Eighty patients with repeat coronary CT angiograms (CCTAs) with different su...
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pub_type: 杂志文章
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-01-01 00:00:00
abstract::Here we report our experience of a neuroprotective adaptation of the technique of CT-guided radiofrequency (RF) ablation of spinal osteoid osteomas. Over 9 years seven patients underwent eight CT-guided RF treatments for osteoid osteoma. CT-guided RF ablation was performed with general anaesthesia. The lesion was heat...
journal_title:European radiology
pub_type: 杂志文章
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更新日期:2009-09-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:European radiology
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更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2019-01-01 00:00:00
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doi:10.1007/s00330-010-1821-8
更新日期:2010-10-01 00:00:00
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doi:10.1007/s00330-020-06874-x
更新日期:2020-10-01 00:00:00
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doi:10.1007/s00330-020-06852-3
更新日期:2020-09-01 00:00:00
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更新日期:2005-06-01 00:00:00
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abstract::Our objective was to study Gd-EOB-DTPA for the characterization of focal liver lesions by means of dynamic MR imaging. A double-blind and randomized dose-ranging phase-2 clinical trial was performed in 31 patients (liver metastases n = 23, hepatocellular carcinoma n = 4, and hemangioma n = 4) at a field strength of 1....
journal_title:European radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s003300050150
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To compare the efficacy of ethanol ablation (EA) of cystic and predominantly cystic thyroid nodules, and to evaluate factors affecting efficacy. METHODS:From October 2008 to December 2010, a total of 217 thyroid nodules were treated with EA. Nodule volumes, symptoms and cosmetic scores were evaluated before...
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更新日期:2012-07-01 00:00:00