Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-κB ligand expression in MG-63 osteoblast-like cells exposed to polyethylene particles.

Abstract:

BACKGROUND:Recent studies demonstrated an impact of the nervous system on particle-induced osteolysis, the major cause of aseptic loosening of joint replacements. METHODS:In this study of MG-63 osteoblast-like cells we analyzed the influence of ultra-high molecular weight polyethylene (UHMWPE) particles and the neurotransmitter alpha-calcitonin gene-related peptide (CGRP) on the osteoprotegerin/receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factorκB (OPG/RANKL/RANK) system. MG-63 cells were stimulated by different UHMWPE particle concentrations (1:100, 1:500) and different doses of alpha-CGRP (10-7 M, 10-9 M, 10-11 M). RANKL and OPG mRNA expression and protein levels were measured by RT-PCR and Western blot. RESULTS:Increasing particle concentrations caused an up-regulation of RANKL after 72 hours. Alpha-CGRP showed a dose-independent depressive effect on particle-induced expression of RANKL mRNA in both cell-particle ratios. RANKL gene transcripts were significantly (P < 0.05) decreased by alpha-CGRP treatment after 48 and 72 hours. OPG mRNA was significantly down-regulated in a cell-particle ratio of 1:500 after 72 hours. Alpha-CGRP concentrations of 10-7 M lead to an up-regulation of OPG protein. CONCLUSION:In conclusion, a possible osteoprotective influence of the neurotransmitter alpha-CGRP on particle stimulated osteoblast-like cells could be shown. Alpha-CGRP might be important for bone metabolism under conditions of particle-induced osteolysis.

journal_name

J Orthop Surg Res

authors

Xu J,Kauther MD,Hartl J,Wedemeyer C,Study was performed at the University of Duisburg - Essen, Germany.

doi

10.1186/1749-799X-5-83

subject

Has Abstract

pub_date

2010-11-04 00:00:00

pages

83

issn

1749-799X

pii

1749-799X-5-83

journal_volume

5

pub_type

杂志文章
  • The combinations of multiple factors to improve the diagnostic sensitivity and specificity after artificial joint infection.

    abstract:OBJECTIVE:To discuss the sensitivity and specificity of the combinations of multiple factors that work on bone infection after artificial joint, and provide evidence-based medical basis for the early diagnosis of infection after artificial joint. METHODS:A retrospective review was conducted on 35 patients diagnosed wi...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-01669-8

    authors: Chu L,Ren YL,Yang JS,Yang J,Zhou H,Jiang HT,Shi L,Hao DJ,Deng ZL

    更新日期:2020-04-25 00:00:00

  • The change of cervical sagittal parameters plays an important role in clinical outcomes of cervical spondylotic myelopathy after multi-level anterior cervical discectomy and fusion.

    abstract:BACKGROUND:Cervical sagittal parameters were closely related with clinical outcomes after multi-level ACDF. Our purpose was to evaluate the clinical outcomes and cervical sagittal parameters in patients with MCSM after ACDF and to identify the risk factors of poor clinical outcomes. MATERIAL AND METHODS:ACDF was perfo...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-019-1504-3

    authors: Fan XW,Wang ZW,Gao XD,Ding WY,Yang DL

    更新日期:2019-12-11 00:00:00

  • Nonoperative treatment versus volar locking plate fixation for elderly patients with distal radial fracture: a systematic review and meta-analysis.

    abstract:BACKGROUND:This systematic review and meta-analysis assessed the role of nonoperative treatment and volar locking plate (VLP) fixation in elderly patients with distal radial fracture. METHODS:The systematic literature review identified randomized controlled trials (RCTs) and observational studies using VLP and nonoper...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章,评审

    doi:10.1186/s13018-020-01734-2

    authors: Li Q,Ke C,Han S,Xu X,Cong YX,Shang K,Liang JD,Zhang BF

    更新日期:2020-07-14 00:00:00

  • Clinical outcomes in distal radial fractures with ipsilateral arteriovenous fistulas.

    abstract:BACKGROUND:We evaluated the effects on arteriovenous fistula (AVF) function and clinical outcomes in patients given cast fixation, external skeletal fixation [ESF], or volar locking plate fixation [VLPF] for an ipsilateral distal radial fracture (DRF). METHODS:Thirteen patients were assigned to the surgery group or th...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-019-1171-4

    authors: Chang HM,Chou YC,Jou IM,Yang JM,Ma CH,Wu PT

    更新日期:2019-05-22 00:00:00

  • Incidence and risks for surgical site infection after closed tibial plateau fractures in adults treated by open reduction and internal fixation: a prospective study.

    abstract:BACKGROUND:Surgical site infection (SSI) was the most common complication of tibial plateau fracture after open reduction and internal fixation (ORIF). Severe infections even required repeat surgeries, which would cause serious psychological harm to patients and increased the economic burden of treatment. In order to i...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-01885-2

    authors: Li J,Zhu Y,Zhao K,Zhang J,Meng H,Jin Z,Ma J,Zhang Y

    更新日期:2020-08-24 00:00:00

  • Infrapatellar fat pad resection or preservation during total knee arthroplasty: a meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:The infrapatellar fat pad (IPFP) or Hoffa's fat pad is often resected during total knee arthroplasty in order to improve visibility. However, the management of the IPFP during total knee arthroplasty (TKA) is the subject of an ongoing debate that has no clear consensus. The purpose of this review was to appr...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章,评审

    doi:10.1186/s13018-020-01823-2

    authors: Sun C,Zhang X,Lee WG,Tu Y,Li H,Cai X,Yang H

    更新日期:2020-08-05 00:00:00

  • Tendoscopic versus open release for de Quervain's disease: earlier recovery with 7.21 year follow-up.

    abstract:PURPOSE:To compare the time return to work and long-term results of tendoscopic versus open technique for de Quervain's disease. METHODS:From 2005 to 2013, either tendoscopic or open decompression was performed on 56 consecutive patients (56 wrists) with symptomatic de Quervain's disease despite a minimum of 3 months ...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-019-1393-5

    authors: Gu XH,Hong ZP,Chen XJ,Tong Y,Hong JF,Luo ZP,Bi Q

    更新日期:2019-11-12 00:00:00

  • Anatomical study of the coracoid process in Mongolian male cadavers using the Latarjet procedure.

    abstract:BACKGROUND:The Latarjet procedure addresses recurrent anterior shoulder instability in the context of a significant bony defect. However, the bony and soft tissue anatomy of the coracoid in coracoid transfer procedures has not yet been defined in Mongolian men. The aims of this study were to describe the soft tissue at...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-016-0461-3

    authors: Lian J,Dong L,Zhao Y,Sun J,Zhang W,Gao C

    更新日期:2016-10-24 00:00:00

  • Comparison of the efficacy of static versus articular spacers in two-stage revision surgery for the treatment of infection following total knee arthroplasty: a meta-analysis.

    abstract:BACKGROUND:The aim of this study was to compare the outcomes of static versus articular spacers in two-stage reimplantation for the treatment of infected total knee arthroplasty (TKA). METHODS:The literature regarding the articulating and static spacers for treating infected TKA were searched in PubMed, Embase, Cochra...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章,meta分析

    doi:10.1186/s13018-017-0644-6

    authors: Ding H,Yao J,Chang W,Liu F

    更新日期:2017-10-17 00:00:00

  • Performance of age-adjusted D-dimer values for predicting DVT before the knee and hip arthroplasty.

    abstract:PURPOSE:To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients. METHODS:We enrolled 406 patients finally above 50 years old. Everyone had done ultrasonography bedside, and D-dime...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-02172-w

    authors: Wu JX,Qing JH,Yao Y,Chen DY,Jiang Q

    更新日期:2021-01-25 00:00:00

  • A biomechanical comparison of 360° stabilizations for corpectomy and total spondylectomy: a cadaveric study in the thoracolumbar spine.

    abstract:BACKGROUND:To date, there has been no adequate biomechanical model that would allow a quantitative comparison in terms of stability/stiffness between a corpectomy with the posterior column preserved and a total spondylectomy with the posterior column sacrificed. The objective of this study was to perform a biomechanica...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-015-0240-6

    authors: Kim JH,Rhee JM,Enyo Y,Hutton WC,Kim SS

    更新日期:2015-07-01 00:00:00

  • Efficacy analysis of percutaneous pedicle screw fixation combined with percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fractures with kyphosis.

    abstract:BACKGROUND:To investigate the clinical effect of percutaneous pedicle screw fixation (PPSF) combined with percutaneous vertebroplasty (PVP) in the treatment of osteoporotic compression vertebral fracture (OVCF) of the thoracolumbar vertebra with kyphosis. METHODS:One hundred sixty-six patients before June 2017 were re...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-1583-1

    authors: Li Z,Wang Y,Xu Y,Xu W,Zhu X,Chen C

    更新日期:2020-02-17 00:00:00

  • Correction to: Open reduction and compression with double Kirschner wires for the treatment of old bony mallet finger.

    abstract::Following publication of the original article [1], we have been notified that there was a spelling mistake in the author affiliations. In this Correction, correct and incorrect versions are shown. ...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s13018-020-01680-z

    authors: Tang J,Wu K,Wang J,Zhang J

    更新日期:2020-04-30 00:00:00

  • Would early removal of indwelling catheter effectively prevent urinary retention after hip fracture surgery in elderly patients?

    abstract:BACKGROUND:This study aimed to investigate the incidence and risk factors of postoperative urinary retention (POUR) among elderly patients who underwent hip fracture surgery and to evaluate the effect of indwelling catheterization on the occurrence of POUR. MATERIALS AND METHODS:From January 2012 to January 2015, cons...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-019-1360-1

    authors: Kwak DK,Oh CY,Lim JS,Lee HM,Yoo JH

    更新日期:2019-09-18 00:00:00

  • Exploring the relationship between bone density and severity of distal radius fragility fracture in women.

    abstract:BACKGROUND:Bone mineral density (BMD) has been shown to be a consistent and independent risk factor for distal radius fracture. Inconsistent data have been reported on the association between BMD and severity of distal radius fracture. Our primary aim was to explore if there is an association between cortical BMD at th...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-014-0057-8

    authors: Dhainaut A,Daibes K,Odinsson A,Hoff M,Syversen U,Haugeberg G

    更新日期:2014-07-17 00:00:00

  • Pigmented villonodular synovitis does not influence the outcome following cementless total hip arthroplasty using ceramic-on-ceramic articulation: a case-control study with middle-term follow-up.

    abstract:BACKGROUND:Pigmented villonodular synovitis (PVNS) is a relatively rare, locally aggressive, and potentially recurrent synovial disease of large joints. The purpose of this study was to investigate (1) the disease recurrence rate and (2) the treatment outcomes including Harris hip scores, complications, and revision fo...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-018-0996-6

    authors: Xu C,Guo H,Bell KL,Kuo FC,Chen JY

    更新日期:2018-11-20 00:00:00

  • Fully automated segmentation of callus by micro-CT compared to biomechanics.

    abstract:BACKGROUND:A high percentage of closed femur fractures have slight comminution. Using micro-CT (μCT), multiple fragment segmentation is much more difficult than segmentation of unfractured or osteotomied bone. Manual or semi-automated segmentation has been performed to date. However, such segmentation is extremely labo...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-017-0609-9

    authors: Bissinger O,Götz C,Wolff KD,Hapfelmeier A,Prodinger PM,Tischer T

    更新日期:2017-07-11 00:00:00

  • Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement.

    abstract:BACKGROUND:Hip osteoarthritis (HOA) is the most common hip disorder and a major cause of disability in the adult population, with an estimated prevalence of end-stage disease and total hip replacement. Thus, the diagnosis, prevention, and treatment of the early stages of the disease in young adults are crucial to reduc...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-01610-z

    authors: Trisolino G,Favero M,Dallari D,Tassinari E,Traina F,Otero M,Goldring SR,Goldring MB,Carubbi C,Ramonda R,Stilli S,Grigolo B,Olivotto E

    更新日期:2020-02-28 00:00:00

  • Bone quality assessment for total hip arthroplasty with intraoperative trabecular torque measurements.

    abstract:BACKGROUND:In cases of poor bone quality, intraoperative torque measurement might be an alternative to preoperative dual-energy X-ray absorptiometry (DXA) to assess bone quality in total hip arthroplasty (THA). METHODS:Trabecular peak torque measurement was applied in 14 paired fresh frozen human femurs. Here, a 6.5 ×...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-014-0109-0

    authors: Klotz MC,Beckmann NA,Bitsch RG,Seebach E,Reiner T,Jäger S

    更新日期:2014-11-13 00:00:00

  • Enhancement of cartilage repair through the addition of growth plate chondrocytes in an immature skeleton animal model.

    abstract:BACKGROUND:The treatment of articular cartilage damage is a major clinical problem. More often, this clinical issue affects children, which forces doctors to find the best treatment method. METHODS:The aim of this experimental study on 2-month-old Landrace pigs was to compare the results of two cartilage defect treatm...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-019-1302-y

    authors: Tomaszewski R,Wiktor Ł,Gap A

    更新日期:2019-08-15 00:00:00

  • Proper detailed parameters for S1 sacral alar iliac screw placement in the Chinese population, a 3D imaging study.

    abstract:BACKGROUND:S1-AI technique may be used as a salvage technique in pelvic fixation of complex spinal deformity surgery. However, the proper detailed parameters in the Chinese population has not been analyzed before to instruct S1-AI screws placement and to ensure the safety of clinical application while the trajectory in...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-018-0739-8

    authors: Wang Y,Hu W,Hu F,Zhang H,Wang T,Wang Y,Zhang X

    更新日期:2018-02-26 00:00:00

  • The 2018 new definition of periprosthetic joint infection improves the diagnostic efficiency in the Chinese population.

    abstract:BACKGROUND:Periprosthetic joint infection (PJI) is a devastating complication following total joint arthroplasty (TJA). Now, the definition of PJI traditionally used in clinical practice was set out by the International Consensus Meeting (ICM) and Infectious Diseases Society (IDSA). There was a new definition proposed ...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-019-1185-y

    authors: Guan H,Fu J,Li X,Chai W,Hao L,Li R,Zhao J,Chen J

    更新日期:2019-05-24 00:00:00

  • Arthroscopic partial trapeziectomy and tendon interposition for thumb carpometacarpal arthritis.

    abstract:BACKGROUND:The purpose of this study was to introduce arthroscopic partial trapeziectomy and tendon interposition for the treatment of symptomatic thumb carpometacarpal arthritis of Eaton stage II or III. METHODS:From August 2001 to April 2009, 23 patients with thumb carpometacarpal arthritis were treated using this t...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-015-0329-y

    authors: Chuang MY,Huang CH,Lu YC,Shih JT

    更新日期:2015-12-18 00:00:00

  • A CT study of the femoral and sciatic nerve periacetabular moving in different hip positions.

    abstract:BACKGROUND:Femoral and sciatic nerves could be damaged during various stages of the periacetabular osteotomy. Changing the position of the hip could be the most effective way of preventing nerve injuries. The purpose of the present study was to investigate the distances of the nerves to various bony landmarks with diff...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-01937-7

    authors: Isin Y,Hapa O,Kara YS,Kilic AI,Balcı A

    更新日期:2020-09-11 00:00:00

  • Predictors of safety margin for coracoid transfer: a cadaveric morphometric analysis.

    abstract:BACKGROUND:The purpose of this study was to investigate the relationship between the bone length available for coracoid transfer without coracoclavicular ligament injury and the distance from the coracoid tip to the attachments of the coracoacromial ligament or pectoralis minor. We hypothesized that cadaver height and ...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-019-1212-z

    authors: Shibata T,Izaki T,Miyake S,Doi N,Arashiro Y,Shibata Y,Irie Y,Tachibana K,Yamamoto T

    更新日期:2019-06-10 00:00:00

  • Immunohistochemical analysis of sensory corpuscles in human transplants of the anterior cruciate ligament.

    abstract:BACKGROUND:Sensory nerve endings in ligaments play an important role for the proprioceptive function. Clinical trials show that the sense of body position does not fully recover in the knee joint after reconstructive surgery of the ruptured anterior cruciate ligament. The aim of this study is to identify sensory corpus...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-01785-5

    authors: Rebmann D,Mayr HO,Schmal H,Hernandez Latorre S,Bernstein A

    更新日期:2020-07-17 00:00:00

  • Straight stem and threaded cup in patients under 60 years of age: 28.8-30.2 years of follow-up.

    abstract:PURPOSE:The aim of this retrospective observational study of one cohort was to evaluate the long-term outcome in patients younger than 60 years after total hip arthroplasty using a straight uncemented stem and an uncemented threaded cup. METHODS:Between 1986 and 1987, 75 hips of 75 patients (mean age, 53.35 ± 6.17 yea...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-02102-w

    authors: Pisecky L,Allerstorfer J,Schauer B,Hipmair G,Hochgatterer R,Böhler N,Gotterbarm T,Klotz MC

    更新日期:2020-11-26 00:00:00

  • Exposure risk of patients with chronic infectious wounds during the COVID-19 outbreak and its countermeasures.

    abstract:BACKGROUND:A large number of cases of pneumonia caused by novel β-coronavirus emerged in Hubei Province, China, at the end of 2019 and demonstrated great potential for transmission. At present, known independent risk factors include age, diabetes, and other chronic diseases, which may be similar to the patients with ch...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-01976-0

    authors: Zhou H,Jin Q,Lu H

    更新日期:2020-10-02 00:00:00

  • Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression.

    abstract:BACKGROUND:Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. BET family proteins, acting as the "readers" of acetylated modifications on histones, have been linked to transcriptional regulation. And a BE...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-019-1091-3

    authors: Dai J,Zhou S,Ge Q,Qin J,Li J,Ju H,Cao Y,Zheng M,Li C,Gao X,Teng H,Jiang Q

    更新日期:2019-02-20 00:00:00

  • Cost-utility analysis of extensile lateral approach versus sinus tarsi approach in Sanders type II/III calcaneus fractures.

    abstract:BACKGROUND:Extensile lateral approach had been recognized as the gold standard technique for displaced intra-articular calcaneus fractures (DIACFs) while sinus tarsi approach had been increasingly valued by surgeons and comparative clinical outcome was shown in both techniques. Appropriate decisions could be made by th...

    journal_title:Journal of orthopaedic surgery and research

    pub_type: 杂志文章

    doi:10.1186/s13018-020-01963-5

    authors: Li Z,Wu X,Zhou H,Xu S,Xiao F,Huang H,Yang Y

    更新日期:2020-09-18 00:00:00