Abstract:
OBJECTIVES:Cancer control outcomes after partial cystectomy (PC) are not well studied. We compared the population-based rates of overall (OS) and cause-specific survival (CSS) in patients with urothelial carcinoma of the urinary bladder (UCB) treated with PC or radical cystectomy (RC). METHODS:Within the Surveillance Epidemiology and End Results-9 database, we identified 7243 patients treated with PC (n = 1573) or RC (n = 5670), who had pathologic T(1-4)N(1-2)M(0) UCB. Matched Kaplan-Meier survival analyses compared the effect of PC vs RC on OS and CSS. RESULTS:In the entire cohort, the OS and CSS estimates at 5 years were 57.2% and 76.4%, respectively, for PC patients and 50.2% and 65.8%, respectively, for RC patients (P < .001). In the cohort matched for age, race, pT stage, pN stage, tumor grade, and year of surgery, at 5 years the OS and CSS estimates were 56.0% and 73.5%, respectively, for PC patients, and 50.9% and 67.5%, respectively, for RC patients (OS, P = .03 and CSS, P < .001). When the number of removed lymph nodes was added to the matching criteria, the 5-year OS and CSS estimates were 57.2% and 70.3%, respectively, for PC patients, and 54.6% and 69.2%, respectively, for RC patients (HR 1.1, P = .3 and HR 1.1, P = .5). CONCLUSIONS:Partial cystectomy does not undermine cancer control in appropriately selected patients with UCB.
journal_name
Urologyjournal_title
Urologyauthors
Capitanio U,Isbarn H,Shariat SF,Jeldres C,Zini L,Saad F,Graefen M,Montorsi F,Perrotte P,Karakiewicz PIdoi
10.1016/j.urology.2009.03.052subject
Has Abstractpub_date
2009-10-01 00:00:00pages
858-64issue
4eissn
0090-4295issn
1527-9995pii
S0090-4295(09)00602-5journal_volume
74pub_type
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