Abstract：
OBJECTIVE:To assess the feasibility of a prehabilitation program for cystectomy patients and to determine the effectiveness of the program in improving strength and functional capacity in the peri-operative period. MATERIALS AND METHODS:This phase I/II study accrued patients ≥60 years old from January 2013 to October 2017 with biopsy-proven bladder cancer, Karnofsky performance score ≥70 and a sedentary baseline lifestyle to participate in a 4-week supervised preoperative exercise training program. Primary outcomes were feasibility and safety; secondary outcomes included changes in fitness, patient-reported QOL, peri-operative complications and readmissions. Student's ttests and Wilcoxon signed-rank test were performed. RESULTS:Fifty-four patients enrolled in the program. Successful completion, defined as patients who began the program and adhered to >70% of the sessions, was attained by 41 of 51 patients (80.4%, 90% CI [71%-90%]). There were no adverse events. Fitness and patient-reported QOL improved postintervention, with sustained improvements in general and mental health 90-days postsurgery. The primary limitation is no control group. CONCLUSION:Prehabilitation prior to cystectomy is feasible, safe, and results in improvements in patient strength, endurance and sustained improvements in patient-reported QOL from baseline. Efforts to further evaluate the impact of prehabilitation in this population in an expanded and randomized fashion are warranted.
journal_name
Urologyjournal_title
Urologyauthors
Kaye DR,Schafer C,Thelen-Perry S,Parker C,Iglay-Reger H,Daignault-Newton S,Qin Y,Morgan TM,Weizer AZ,Kaffenberger SD,Herrel LA,Hafez KS,Lee CT,Skolarus TA,Englesbe MJ,Montgomery JSdoi
10.1016/j.urology.2020.05.104subject
Has Abstractpub_date
2020-11-01 00:00:00pages
106-112eissn
0090-4295issn
1527-9995pii
S0090-4295(20)30933-Xjournal_volume
145pub_type
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