Environmental cue-dependent dopaminergic neuronal differentiation and functional effect of grafted neuroepithelial stem cells in parkinsonian brain.

Abstract:

OBJECTIVE:To physiologically repair damaged neural circuitry using neural transplantation, the donor cells must be able to differentiate into the optimal type and number of neurons for the host brain environment. They must also be capable of functional regulation by the host brain. These features are important to optimize functional outcome and to minimize side effects. In this study, the differentiation of grafted mesencephalic neuroepithelial stem cells in the normal and parkinsonian brain was assessed morphologically and behaviorally to confirm the influence of the host brain environment after neural transplantation regarding functional outcome and side effects of transplants. METHODS:Green fluorescent protein-positive mesencephalic neuroepithelial stem cells were dissected from early rat embryos and transplanted into normal (n = 20) and Parkinson's disease (PD) rat model striata (n = 30). The differentiation pattern of grafted cells was precisely monitored immunohistochemically, and the functional effects of grafted cells on behavior were assessed using an amphetamine-induced rotation test. RESULTS:The grafted cells survived in both normal and PD rat striata and differentiated into tyrosine hydroxylase-positive cells. In 8-week-old grafts, the number of tyrosine hydroxylase-positive cells was 3-fold higher in parkinsonian brains than in normal brains. The donor-derived tyrosine hydroxylase-positive cells exhibited a mature morphology with long, well-branched cell processes and large cell bodies, especially in parkinsonian brains. Also, the process lengths of these cells in parkinsonian brains were 3.4-fold longer than those in normal brains at 8 weeks after transplantation. The grafted PD rats exhibited a complete recovery from their behavioral defects, and no obvious contralateral rotation to the lesioned and grafted side suggestive of overdose supply from the graft was observed. However, the grafted normal rats did not exhibit any contralateral rotation to the grafted side suggestive of dopamine unbalance. CONCLUSION:Grafted mesencephalic neuroepithelial stem cells can differentiate into optimal neuron types in response to environmental cues and can affect the behavior of PD rats without any side effects.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Mine Y,Hayashi T,Yamada M,Okano H,Kawase T

doi

10.1227/01.NEU.0000351281.45986.76

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

741-53; discussion 753

issue

4

eissn

0148-396X

issn

1524-4040

pii

00006123-200910000-00013

journal_volume

65

pub_type

杂志文章
  • The localizing value of asymmetry in pupillary size in severe head injury: relation to lesion type and location.

    abstract::Reliable Assessment of the probability that a head injury patient harbors a surgical intracranial lesion is critical to both triage and treatment. The authors analyzed data from 608 patients with severe head injuries (Glasgow Coma Scale score, < or = 8) in the Traumatic Coma Data Bank to assess the reliability of pupi...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199405000-00008

    authors: Chesnut RM,Gautille T,Blunt BA,Klauber MR,Marshall LE

    更新日期:1994-05-01 00:00:00

  • Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin.

    abstract:OBJECTIVE:The snake venom disintegrin contortrostatin (CN) is able to inhibit tumor progression and angiogenesis in vivo and therefore is of considerable interest as a potential antitumor drug. CN specifically binds to certain integrins on the tumor cell and angiogenic endothelial cell surface and inhibits their intera...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000163426.25227.56

    authors: Schmitmeier S,Markland FS,Schönthal AH,Chen TC

    更新日期:2005-07-01 00:00:00

  • Reactivation of herpes virus after surgery for epilepsy in a pediatric patient with mesial temporal sclerosis: case report.

    abstract:OBJECTIVE:This case report is presented to raise the awareness of the potential risk of reactivation of herpes simplex virus (HSV) encephalitis after intracranial surgery. CLINICAL PRESENTATION:The case of an 8-year-old male patient who suffered a reactivation of HSV encephalitis after undergoing amygdalohippocampecto...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199903000-00106

    authors: Bourgeois M,Vinikoff L,Lellouch-Tubiana A,Sainte-Rose C

    更新日期:1999-03-01 00:00:00

  • Impairment of motor recovery after late nerve suture: experimental study in the rabbit. Part 1: functional and electromyographic findings.

    abstract::To study the motor recovery after increasingly late nerve suture, we severed 75 rabbit peroneal nerves and reanastomosed them by microsurgical epineural technique after a delay of up to 12 months. Functional, electromyographic, and morphological parameters were used to evaluate the quality of motor function 6 months a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Richter HP

    更新日期:1982-01-01 00:00:00

  • Analysis of intraoperative rupture in the surgical treatment of 1694 saccular aneurysms.

    abstract:OBJECTIVE:Intraoperative rupture (IOR) of an aneurysm is a known risk in the surgical management of intracranial aneurysms. The purpose of this study was to determine the incidence of IOR in a modern surgical series and to assess which factors bear upon it. METHODS:This study retrospectively examined 1269 patients wit...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/01.neu.0000154697.75300.c2

    authors: Leipzig TJ,Morgan J,Horner TG,Payner T,Redelman K,Johnson CS

    更新日期:2005-03-01 00:00:00

  • Symptoms of Depression are Common in Patients With Idiopathic Normal Pressure Hydrocephalus: The INPH-CRasH Study.

    abstract:BACKGROUND:If patients with idiopathic normal pressure hydrocephalus (INPH) also have depression, this could have important clinical ramifications in assessment and management of their cognitive function and response to shunting. In many dementias, depression is overrepresented, but the prevalence of depression in shun...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/NEU.0000000000001093

    authors: Israelsson H,Allard P,Eklund A,Malm J

    更新日期:2016-02-01 00:00:00

  • Intraventricular neurocytoma: a clinical and pathological study of three cases and review of the literature.

    abstract::Three patients with a recently described tumor of neuronal origin, intraventricular neurocytoma, are presented. These tumors occur as intraventricular lesions in young patients, and the prognosis after surgical treatment is favorable. The initial pathological diagnosis of intraventricular neurocytoma may be difficult ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:

    authors: Barbosa MD,Balsitis M,Jaspan T,Lowe J

    更新日期:1990-06-01 00:00:00

  • What is the Surgical Benefit of Utilizing 5-Aminolevulinic Acid for Fluorescence-Guided Surgery of Malignant Gliomas?

    abstract::The current neurosurgical goal for patients with malignant gliomas is maximal safe resection of the contrast-enhancing tumor. However, a complete resection of the contrast-enhancing tumor is achieved only in a minority of patients. One reason for this limitation is the difficulty in distinguishing viable tumor from no...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/NEU.0000000000000929

    authors: Hadjipanayis CG,Widhalm G,Stummer W

    更新日期:2015-11-01 00:00:00

  • Simple method for determining the need for sternotomy/manubriotomy with the anterior approach to the cervicothoracic junction.

    abstract:OBJECTIVE:Frequently, the cervicothoracic junction can be reached through a simple anterior approach. In some cases, access to this region requires a much more aggressive surgical intervention, such as manubriotomy or sternotomy. Information regarding the need for such interventions is particularly useful to have preop...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000347472.07670.EB

    authors: Karikari IO,Powers CJ,Isaacs RE

    更新日期:2009-12-01 00:00:00

  • Percutaneous minidose metrizamide endomyelographic computed tomography in syringomyelia.

    abstract::Two patients presented with syringomyelia, each unusual. After neuroradiographic diagnosis with delayed metrizamide computed tomography (CT) or magnetic resonance imaging (MRI), an interesting diagnostic question arose. A percutaneous minidose metrizamide endomyelographic CT (PMDMECT) study clarified each situation an...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198703000-00013

    authors: Blumenkopf B

    更新日期:1987-03-01 00:00:00

  • Magnetic microparticles for endovascular aneurysm treatment: in vitro and in vivo experimental results.

    abstract:OBJECTIVE:Endovascular treatment of intracranial aneurysms employing endosaccular coiling can be associated with aneurysm perforation, coil herniation or incomplete obliteration fueling the interest to investigate novel endovascular techniques. We aimed to test a novel embolization material in experimental aneurysms in...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e3182125eb0

    authors: Oechtering J,Kirkpatrick PJ,Ludolph AG,Hans FJ,Sellhaus B,Spiegelberg A,Krings T

    更新日期:2011-05-01 00:00:00

  • Prognostic significance of type 1 neurofibromatosis (von Recklinghausen Disease) in childhood optic glioma.

    abstract::Although the association between optic glioma and neurofibromatosis is well recognized, few studies have systematically compared the outcomes of patients with optic gliomas and neurofibromatosis and patients with optic gliomas without neurofibromatosis. In the present study, patients with optic gliomas and Type 1 neur...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199606000-00010

    authors: Deliganis AV,Geyer JR,Berger MS

    更新日期:1996-06-01 00:00:00

  • Stereotactic craniotomy: methods and results using the Brown-Roberts-Wells stereotactic frame.

    abstract::Combining the power of stereotactic precision with open craniotomy in a stereotactic craniotomy technique decreases surgical time, morbidity, and postoperative hospitalization. Indications for its use are deep intrinsic masses 3.5 cm or less in diameter; small, superficial lesions otherwise difficult to localize; and ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Moore MR,Black PM,Ellenbogen R,Gall CM,Eldredge E

    更新日期:1989-10-01 00:00:00

  • Metastases of a spinal glioblastoma multiforme into an intracranial arachnoid cyst.

    abstract::Spread of spinal cord glioblastoma multiforme to the intracranial compartment is uncommon. This report documents a case of metastatic spread of glioblastoma multiforme from the spinal cord to an intracranial arachnoid cyst. Seeding of the cyst cavity could have occurred by direct permeation of the cyst wall by the neo...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198705000-00018

    authors: Kendrick FD,Bonnin JM,Garcia JH

    更新日期:1987-05-01 00:00:00

  • The abducted arm as a sign of ruptured cervical disc.

    abstract::A helpful clinical sign of ruptured cervical disc is pain relief upon arm abduction. When the disease process is spondylosis with foraminal stenosis, changing arm position does not relieve pain. Anatomical considerations are discussed. ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198711000-00024

    authors: Beatty RM,Fowler FD,Hanson EJ Jr

    更新日期:1987-11-01 00:00:00

  • A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation.

    abstract:BACKGROUND:Although there are several large-species animal models for saccular aneurysms, there is a need for a simple, reproducible saccular aneurysm model in mice. OBJECTIVE:To develop a murine saccular aneurysm model, which replicates key characteristics that occur in the formation of human cerebral aneurysms. MET...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000365616.46414.2B

    authors: Hoh BL,Velat GJ,Wilmer EN,Hosaka K,Fisher RC,Scott EW

    更新日期:2010-03-01 00:00:00

  • Carpal tunnel syndrome: correlation of magnetic resonance imaging, clinical, electrodiagnostic, and intraoperative findings.

    abstract::We undertook a prospective study of 43 wrists in 32 patients who had been clinically diagnosed as having carpal tunnel syndrome (study group) and 5 wrists in people who had no symptoms (control group), correlating the clinical, electrodiagnostic, intraoperative, and magnetic resonance imaging (MRI) findings. MRI of th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199512000-00009

    authors: Britz GW,Haynor DR,Kuntz C,Goodkin R,Gitter A,Kliot M

    更新日期:1995-12-01 00:00:00

  • Incidence and clinical implications of carotid branch occlusion following treatment of internal carotid artery aneurysms with the pipeline embolization device.

    abstract:BACKGROUND:The use of flow diverters such as the pipeline embolization device (PED) for treatment of intracranial aneurysms carries the risk of side branch occlusion. OBJECTIVE:To determine the incidence and clinical outcomes associated with supraclinoid internal carotid artery (ICA) branch occlusion after deployment ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000595

    authors: Vedantam A,Rao VY,Shaltoni HM,Mawad ME

    更新日期:2015-02-01 00:00:00

  • Rapid Stretch Injury to Peripheral Nerves: Biomechanical Results.

    abstract:BACKGROUND:Although most adult brachial plexus injuries result from high-speed mechanisms, no laboratory model has been created to mimic rapid-stretch nerve injuries. Understanding the biomechanical response of nerves to rapid stretch is essential to understanding clinical injury patterns and developing models that mim...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyy423

    authors: Mahan MA,Yeoh S,Monson K,Light A

    更新日期:2019-07-01 00:00:00

  • Balloon-in-stent technique for the constructive endovascular treatment of "ultra-wide necked" circumferential aneurysms.

    abstract:INTRODUCTION:Circumferential aneurysms, which incorporate >180 degrees of the circumference of the parent vessel, present a unique therapeutic challenge, particularly in circumstances in which a deconstructive treatment strategy is not feasible. We detail a novel technique for endovascular parent vessel reconstruction ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/01.neu.0000186036.35823.10

    authors: Fiorella D,Albuquerque FC,Masaryk TJ,Rasmussen PA,McDougall CG

    更新日期:2005-12-01 00:00:00

  • Results of nerve transfers to the musculocutaneous and axillary nerves.

    abstract:OBJECTIVE:Nerve transfers in cases of brachial plexus traction injuries with avulsion of spinal nerve roots or irreparable proximal lesions of spinal nerves have been attempted using a variety of donor nerves. The purpose of this study was to analyze the results of nerve transfers to the musculocutaneous and axillary n...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Samardzić M,Rasulić L,Grujicić D,Milicić B

    更新日期:2000-01-01 00:00:00

  • Traumatic atlanto-occipital dislocation with survival: case report and review.

    abstract::Traumatic atlanto-occipital (A-O) dislocation is a rare injury that is associated with a high mortality rate. We are presenting the case of a 5-year-old child with this entity to illustrate the mechanism of injury, the often-confusing clinical picture, and the use of diaphragmatic fluoroscopy to localize the neurologi...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198011000-00017

    authors: Pang D,Wilberger JE Jr

    更新日期:1980-11-01 00:00:00

  • Extreme lateral disc herniation: diagnosis by computed tomographic scanning.

    abstract::Extreme lateral disc herniation with compression of the nerve root as it exits through the foramen has been a recognized entity for a number of years. Until recently, this diagnosis was made infrequently except at the time of operation. Reported here are 12 cases of root compression from disc herniation at the level o...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198405000-00004

    authors: Godersky JC,Erickson DL,Seljeskog EL

    更新日期:1984-05-01 00:00:00

  • The effect of early isolated lumbar extension exercise program for patients with herniated disc undergoing lumbar discectomy.

    abstract:OBJECTIVE:To determine the effects of a postoperative early isolated lumbar extension muscle-strengthening program on pain, disability, return to work, and power of back muscle after operation for herniated lumbar disc. METHODS:Seventy-five patients were randomized into an exercise group (20 men, 15 women) and a contr...

    journal_title:Neurosurgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/neurosurgery/57.4.764

    authors: Choi G,Raiturker PP,Kim MJ,Chung DJ,Chae YS,Lee SH

    更新日期:2005-10-01 00:00:00

  • External validation of the international mission for prognosis and analysis of clinical trials model and the role of markers of coagulation.

    abstract:BACKGROUND:Markers of coagulation have shown to have important value in predicting traumatic brain injury outcome. OBJECTIVE:To externally validate and investigate the role of markers of coagulation for outcome prediction by using the International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) model w...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000430326.40763.ec

    authors: Raj R,Siironen J,Kivisaari R,Hernesniemi J,Tanskanen P,Handolin L,Skrifvars MB

    更新日期:2013-08-01 00:00:00

  • Immediate stiffness of the C5-C6 segment after discectomy with the Cloward technique: an in vitro biomechanical study on a human cadaveric model.

    abstract:OBJECTIVE:To determine whether the Cloward technique of cervical discectomy and fusion increases immediate postoperative stiffness of single cervical motion segment after application of interbody dowel bone graft. METHODS:We measured and compared the stiffness of single-motion segments in cadaveric cervical spines bef...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200112000-00019

    authors: Maciejczak A,Ciach M,Radek M Jr,Radek A,Awrejcewicz J

    更新日期:2001-12-01 00:00:00

  • Clinical utility of allogeneic skull discs in human craniotomy.

    abstract::One hundred fifteen burr hole defects were filled with sterilized human cadaver skull in 45 patients ranging in age between 10 and 88 years. One to 6 allogeneic skull discs per patient were placed in all areas of the calvaria. The length of postoperative observation ranges between 6 months and 5 years. No instances of...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198402000-00011

    authors: Prolo DJ,Gutierrez RV,DeVine JS,Oklund SA

    更新日期:1984-02-01 00:00:00

  • Successful separation of craniopagus parasiticus.

    abstract:OBJECTIVE:Craniopagus parasiticus is an extremely rare condition. The first attempt to separate such twins was performed in the Dominican Republic in 2004. The infant died 7 hours after surgery. The aim of this report is to present a case in which surgical separation was successfully performed on February 18, 2005. In ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000245587.23710.A6

    authors: Lotfy M,Sakr SA,Ayoub BM

    更新日期:2006-11-01 00:00:00

  • Hyperbaric oxygen in the treatment of a radiosurgical complication: technical case report.

    abstract:OBJECTIVE:Hyperbaric oxygenation is a rarely used method of treatment for steroid-refractory radiation-induced edema after stereotactic radiosurgery. We present its successful implementation for a radiosurgical complication after the treatment of a deep, large arteriovenous malformation. We also review the literature o...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000255343.41206.6F

    authors: Lynn M,Friedman WA

    更新日期:2007-03-01 00:00:00

  • Intra-arterial Cereport (RMP-7) and carboplatin: a dose escalation study for recurrent malignant gliomas.

    abstract:OBJECTIVE:Animal and human studies have shown increased delivery of radiolabeled compounds across the blood-brain-tumor barrier using intra-arterial (IA) Cereport (RMP-7; Alkermes Inc., Cambridge, MA) with a radiolabeled tracer. This present study assesses the safety, tolerance, and preliminary efficacy of the IA admin...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199902000-00015

    authors: Cloughesy TF,Black KL,Gobin YP,Farahani K,Nelson G,Villablanca P,Kabbinavar F,Viñeula F,Wortel CH

    更新日期:1999-02-01 00:00:00