A randomized clinical trial of the effects of saphenous and perforating veins radiofrequency ablation on venous ulcer healing (VUERT trial).

Abstract:

OBJECTIVES:To investigate whether radiofrequency endovenous ablation (RFA) of saphenous and perforating veins increases venous leg ulcer (VLU) healing rates and prevents ulcer recurrence. METHOD:This prospective, open-label, randomized, controlled, single-center trial recruited 56 patients with VLU divided into: compression alone (CR, N = 29) and RFA plus compression (RF, N = 27). Primary endpoints were ulcer recurrence rate at 12 months; and ulcer healing rates at 6, 12, and 24 weeks. Secondary endpoints were ulcer healing velocity; and Venous Clinical Severity Score (VCSS). RESULTS:Recurrence was lower in the RF group (p < .001), as well as mean VCSS after treatment (p = .001). There were no significant between-group differences in healing rates. Healing velocity was faster in the RF group (p = 0.049). In the RF group, 2 participants had type 1 endovenous heat-induced thrombosis (EHIT). CONCLUSIONS:RFA plus compression is an excellent treatment for VLU because of its safety, effectiveness, and impact on ulcer recurrence reduction and clinical outcome.Registration: Clinicaltrials.gov, NCT03293836, clinicaltrials.gov.

journal_name

Phlebology

journal_title

Phlebology

authors

Puggina J,Sincos IR,Campos W Jr,Porta RMP,Dos Santos JB,De Luccia N,Puech-Leão P,Collares FB,da Silva ES

doi

10.1177/0268355520951697

subject

Has Abstract

pub_date

2020-09-14 00:00:00

pages

268355520951697

eissn

0268-3555

issn

1758-1125

pub_type

杂志文章
  • Popliteal venous aneurysm: a report on three cases presenting with chronic venous insufficiency without embolic events.

    abstract:OBJECTIVES:Popliteal venous aneurysms (PVA) are rare, but represent a significant potential source of thromboembolus. Most often the patients present with pulmonary embolism, which can also be detected in patients presenting with chronic venous insufficiency. METHODS:Three patients without any clinical evidence of pul...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1258/026835507780346204

    authors: Christenson JT

    更新日期:2007-01-01 00:00:00

  • Inferior vena cava filters utilization in patients with venous thromboembolism: Analysis of a database of a tertiary hospital.

    abstract:PURPOSE:The aim of the study was to assess the inferior vena cava filter (IVCF) utilization in patients with venous thromboembolism (VTE) in tertiary care. METHODS:We performed a retrospective analysis of database of a tertiary hospital in 2016-2017. All the records of patients admitted for VTE or diagnosed with VTE b...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355520975582

    authors: Arslanbekov MM,Efremova OI,Lebedev IS,Kirienko AI,Zolotukhin IA

    更新日期:2020-12-13 00:00:00

  • Wound care in venous ulcers.

    abstract::Wound dressings: ulcer dressings should create and maintain a moist environment on the ulcer surface. It has been shown that in an ulcer with a hard crust and desiccated bed, the healing process is significantly slowed and sometimes completely blocked so favouring infection, inflammation and pain. In contrast a moist ...

    journal_title:Phlebology

    pub_type: 杂志文章,评审

    doi:10.1177/0268355513477015

    authors: Mosti G

    更新日期:2013-03-01 00:00:00

  • Clarivein® mechano-chemical ablation an interim analysis of a randomized controlled trial dose-finding study.

    abstract:OBJECTIVES:The ClariVein® system is an endovenous technique that uses mechano-chemical ablation to treat incompetent truncal veins. This study was conducted to identify the ideal Polidocanol dosage and form for mechano-chemical ablation in order to occlude the great saphenous vein. When adhering to safe dosage levels, ...

    journal_title:Phlebology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/0268355515599692

    authors: Lam YL,Toonder IM,Wittens CH

    更新日期:2016-04-01 00:00:00

  • The treatment of upper extremities deep vein thrombosis related to thoracic outlet syndrome with direct oral anticoagulants.

    abstract::Venous thoracic outlet syndrome (VTOS) is a manifestation of venous symptoms that occurs when the subclavian vein is compressed and it may present clinically with acute venous thrombosis of the axillo-subclavian vein. Evidence for the optimal approach to the management of this condition is sparse and actually anticoag...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355520967519

    authors: Fiori L,Serrao A,Ferretti A,Chistolini A

    更新日期:2020-10-27 00:00:00

  • Radiofrequency-induced thermal therapy: results of a European multicentre study of resistive ablation of incompetent truncal varicose veins.

    abstract:OBJECTIVES:To investigate the effectiveness of bipolar radiofrequency-induced thermal therapy (RFITT) in a multicentre non-randomized study. METHODS:Some 672 incompetent saphenous veins (85% great saphenous varicose vein, 15% short saphenous vein) in 462 patients (56.5% CEAP [clinical, aetiological, anatomical and pat...

    journal_title:Phlebology

    pub_type: 杂志文章,多中心研究

    doi:10.1258/phleb.2012.012013

    authors: Braithwaite B,Hnatek L,Zierau U,Camci M,Akkersdijk G,Nio D,Sarlija M,Ajduk M,Santoro P,Roche E

    更新日期:2013-02-01 00:00:00

  • Strip-tract revascularization as a source of recurrent venous reflux following high saphenous tie and stripping: results at 5-8 years after surgery.

    abstract:OBJECTIVE:We have previously reported strip-tract revascularization 1 year following high saphenous ligation and inversion stripping. This study reports the 5-8 year results in the same cohort. METHODS:Between 2000 and 2003, 72 patients presented with primary varicose veins and had undergone high saphenous ligation an...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355514535927

    authors: Ostler AE,Holdstock JM,Harrison CC,Price BA,Whiteley MS

    更新日期:2015-09-01 00:00:00

  • Comparison of the effects of endovenous laser ablation at 1470 nm versus 1940 nm and different energy densities.

    abstract:OBJECTIVES:To evaluate histological and immunohistochemical changes in the great saphenous vein after endovenous laser ablation at two different wavelengths (1470 vs. 1940 nm) and linear endovenous energy density values (50 vs. 100 J/cm). METHOD:Segments were obtained from the conventional eversion removal of great sa...

    journal_title:Phlebology

    pub_type: 临床试验,杂志文章

    doi:10.1177/0268355518778488

    authors: de Araujo WJB,Timi JRR,Kotze LR,Vieira da Costa CR

    更新日期:2019-04-01 00:00:00

  • Foam sclerotherapy techniques: different gases and methods of preparation, catheter versus direct injection.

    abstract:INTRODUCTION:Foam sclerotherapy has gained a great popularity among phlebologists worldwide, although a major lack of homogeneity in the material used to produce sclerosant foam (SF) and to inject SF has been reported. AIMS:To highlight the literature data and a few personal clinical and experimental outcomes concerni...

    journal_title:Phlebology

    pub_type: 杂志文章,评审

    doi:10.1258/phleb.2009.009061

    authors: Cavezzi A,Tessari L

    更新日期:2009-12-01 00:00:00

  • European guidelines for sclerotherapy in chronic venous disorders.

    abstract:AIM:Sclerotherapy is the targeted chemical ablation of varicose veins by intravenous injection of a liquid or foamed sclerosing drug. The treated veins may be intradermal, subcutaneous, and/or transfascial as well as superficial and deep in venous malformations. The aim of this guideline is to give evidence-based recom...

    journal_title:Phlebology

    pub_type: 杂志文章,实务指引

    doi:10.1177/0268355513483280

    authors: Rabe E,Breu FX,Cavezzi A,Coleridge Smith P,Frullini A,Gillet JL,Guex JJ,Hamel-Desnos C,Kern P,Partsch B,Ramelet AA,Tessari L,Pannier F,Guideline Group.

    更新日期:2014-07-01 00:00:00

  • Epidemiology, risk factors and sequelae of venous thromboembolism.

    abstract::The aim of this review was to discuss the epidemiology, risk factors and sequelae of venous thromboembolism (VTE). VTE has an incidence of 1-2 per 1000 people annually. The risk of VTE increases with age and is highest in Caucasians and African Americans. Combined oral contraceptives (COC), especially the third-genera...

    journal_title:Phlebology

    pub_type: 杂志文章,评审

    doi:10.1258/phleb.2012.012s31

    authors: Wong P,Baglin T

    更新日期:2012-01-01 00:00:00

  • Anatomy and embryology of the small saphenous vein: nerve relationships and implications for treatment.

    abstract::The aim of this paper is to describe the anatomical relations of the small saphenous vein (SSV) in order to define the high-risk zones for the treatment of chronic venous disease. The SSV runs in the saphenous compartment demarcated by two fascia layers: a muscular fascia and a membranous layer of subcutaneous tissue....

    journal_title:Phlebology

    pub_type: 杂志文章,评审

    doi:10.1258/phleb.2012.012j08

    authors: Uhl JF,Gillot C

    更新日期:2013-02-01 00:00:00

  • Ultrastructure of internal jugular vein defective valves.

    abstract:OBJECTIVES:To study the ultrastructure of intraluminal defects found in the internal jugular vein by using a scanning electron microscopy. METHODS:Using a scanning electron microscopy, intraluminal septa and/or defective valves blocking the flow in the distal internal jugular vein of seven patients were studied togeth...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355514541980

    authors: Zamboni P,Tisato V,Menegatti E,Mascoli F,Gianesini S,Salvi F,Secchiero P

    更新日期:2015-10-01 00:00:00

  • Endovenous laser ablation for persistent and recurrent venous ulcers after varicose vein surgery.

    abstract::A 75-year-old woman presented with painful recurrent venous ulcers (VU) continuously for the past 33 months on a background of frequent intermittent problems for the last 16 years. She had previously been treated with varicose vein surgery and trials of compression bandaging. Subsequently, she underwent endovenous las...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1258/phleb.2008.006044

    authors: Kambal AA,De'Ath HD,Albon H,Watson A,Shandall A,Greenstein D

    更新日期:2008-01-01 00:00:00

  • Valsalva maneuver in phlebologic practice.

    abstract::Forced expiration against an airway obstruction was originally described as a method for inflating the Eustachian tubes and is accredited to Antonio Maria Valsalva (1666-1723). The Valsalva maneuver is commonly applied for different diagnostic purposes. Its use for phlebologic diagnosis is the object this review. Veno...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355516678513

    authors: Ricci S,Moro L,Minotti GC,Incalzi RA,De Maeseneer M

    更新日期:2018-03-01 00:00:00

  • Direct oral anticoagulants for the treatment of Mondor's disease not responding to low-molecular weight heparin.

    abstract::Mondor's disease is a rare condition and usually treated with low-molecular weight heparin and non-steroidal anti-inflammatory drugs. Because of paucity of cases and for the usually spontaneous resolution, there is not a standard treatment strategy and the use of oral anticoagulation in controversial. We reported the ...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355520925022

    authors: Serrao A,Lucani B,Baldacci E,Fiori L,Chistolini A

    更新日期:2020-10-01 00:00:00

  • Guidelines for the management of varicose veins.

    abstract::Recently published evidence-based guidelines of the Society for Vascular Surgery (SVS) and the American Venous Forum (AVF) include recommendations for evaluation, classification, outcome assessment and therapy of patients with varicose veins and more advanced chronic venous insufficiency (CVI). The need for such guide...

    journal_title:Phlebology

    pub_type: 杂志文章,评审

    doi:10.1258/phleb.2012.012s28

    authors: Gloviczki P,Gloviczki ML

    更新日期:2012-03-01 00:00:00

  • The use of compression stockings for venous disorders in Brazil.

    abstract:OBJECTIVE:The aim of this study was to analyse the medical indication and the use of elastic compression stockings, and to assess patient adherence to treatment in different regions of Brazil. METHOD:The prescription and clinical indication of elastic stockings were evaluated in a prospective, descriptive, cross-secti...

    journal_title:Phlebology

    pub_type: 杂志文章,多中心研究

    doi:10.1258/phleb.2011.010088

    authors: Cataldo JL,de Godoy JM,de Barros N

    更新日期:2012-02-01 00:00:00

  • Retrospective cohort study for evaluating the INR monitoring patterns in patients with deep vein thrombosis in daily practice: Analysis of 2010-2013 database of a tertiary care center.

    abstract:OBJECTIVE:To evaluate the international normalized ratio (INR) monitoring patterns in patients with deep vein thrombosis. METHODS:Of 32,012 patients with ≥1 outpatient INR measurement and 42,582 patients with confirmed deep vein thrombosis diagnosis registered to our hospital between 1 January 2010 and 31 December 201...

    journal_title:Phlebology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1177/0268355518806117

    authors: Sargin M,Tasdemir MM,Kuplay H,Erdogan SB,Tandogar N,Akansel S,Kurc E,Orhan G,Aka SA

    更新日期:2019-06-01 00:00:00

  • French sclerotherapy and compression: Practice patterns.

    abstract:UNLABELLED:Based on the recommendations of experts, and supported by a low level of proof, compression after sclerotherapy is applied all over the world. OBJECTIVE:Investigating the practice of French vascular physicians for sclerotherapy and the use of post-sclerotherapy compression. METHODS:A questionnaire concerni...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355514554024

    authors: Tripey V,Monsallier JM,Morello R,Hamel-Desnos C

    更新日期:2015-10-01 00:00:00

  • Pain in the aftermath of minimal invasive treatment for unilateral incompetence of the great saphenous vein.

    abstract:OBJECTIVES:Assessment of postprocedural pain after minimal invasive treatment of unilateral incompetence of the great saphenous vein. METHODS:A total of 85 patients treated with endovenous laser ablation (1470 nm) in combination with foam sclerotherapy and evulsions reported postprocedural pain on a visual analogue sc...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355520930639

    authors: Bossart S,Amsler F,Romer-Schenk G,Duchini S,Willenberg T

    更新日期:2020-10-01 00:00:00

  • Pathophysiology of wound healing and alterations in venous leg ulcers-review.

    abstract::Venous leg ulcer (VLU) is one of the most common lower extremity ulcerated wound, and is a significant healthcare problem with implications that affect social, economic, and the well-being of a patient. VLU can have debilitating related problems which require weekly medical care and may take months to years to heal. T...

    journal_title:Phlebology

    pub_type: 杂志文章,评审

    doi:10.1177/0268355516632998

    authors: Raffetto JD

    更新日期:2016-03-01 00:00:00

  • Venous tonus enhancement after a short cycle of intermittent pneumatic compression.

    abstract:OBJECTIVES:To test if intermittent pneumatic compression (IPC) used with a short cycle could reproduce and confirm the 30 min vasoconstriction effect observed after a long cycle of pressure. METHODS:Eighteen subjects took part in the study, 12 with venous insufficiency (VI) and six without VI (NonVI). Duplex scanner w...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1258/phleb.2007.007021

    authors: Harfouche JN,Theys S,Hanson P,Schoevaerdts JC,Sturbois X

    更新日期:2008-01-01 00:00:00

  • Sclerotherapy of varicose veins in patients with documented thrombophilia: a prospective controlled randomized study of 105 cases.

    abstract:OBJECTIVES:The aim of this study was to assess thrombotic complications following sclerotherapy in thrombophilic patients in combination with thromboprophylaxis, in two randomized arms using low molecular weight heparin (LMWH) or warfarin. Patients and methods This study received approval from the Ethics Committee. A t...

    journal_title:Phlebology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1258/phleb.2009.008081

    authors: Hamel-Desnos CM,Gillet JL,Desnos PR,Allaert FA

    更新日期:2009-08-01 00:00:00

  • Re-modelling of venous thrombosis.

    abstract::Venous thromboembolism is one of the most common causes of morbidity and mortality in modern societies. The entirety of events involved in venous thrombus formation and resolution remains to be elucidated. Temporal relation between the initial cellular insult, thrombus formation and resolution is critical for institut...

    journal_title:Phlebology

    pub_type: 杂志文章,评审

    doi:10.1177/0268355513476638

    authors: Malgor RD,Labropoulos N

    更新日期:2013-03-01 00:00:00

  • The European burden of primary varicose veins.

    abstract:BACKGROUND:The treatment of varicose veins has been demonstrated to improve quality of life, alleviate symptoms of depression and treat the complications of venous disease. This study aims to show the studies which contain information regarding the prevalence and distribution of venous disease. Then using the populatio...

    journal_title:Phlebology

    pub_type: 杂志文章,评审

    doi:10.1177/0268355512475118

    authors: Moore HM,Lane TR,Thapar A,Franklin IJ,Davies AH

    更新日期:2013-03-01 00:00:00

  • Patterns in the management of superficial vein thrombosis.

    abstract::Objective To highlight current practice patterns in management of superficial vein thrombosis. Methods An electronic survey was conducted using the mailing lists of the Mediterranean League of Angiology and Vascular Surgery and European Venous Forum regarding superficial vein thrombosis diagnosis, investigation, and t...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355516641003

    authors: Karathanos C,Spanos K,Lachanas V,Athanasoulas A,Giannoukas AD

    更新日期:2017-04-01 00:00:00

  • Subfascial endoscopic perforator surgery for posterolateral perforators performed in the prone position.

    abstract:OBJECTIVES:Subfascial endoscopic perforator surgery (SEPS) is usually performed for posteromedial perforators in the supine position, but subfascial endoscopic perforator surgery for posterolateral perforators in the prone position has not been reported. METHODS:A 51-year-old male suffered from a venous stasis ulcer a...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355513492511

    authors: Kusagawa H,Shomura S,Komada T,Katayama Y,Haruta N

    更新日期:2014-10-01 00:00:00

  • A multi-centre randomised controlled trial comparing radiofrequency and mechanical occlusion chemically assisted ablation of varicose veins - Final results of the Venefit versus Clarivein for varicose veins trial.

    abstract::Background Endovenous thermal ablation has revolutionised varicose vein treatment. New non-thermal techniques such as mechanical occlusion chemically assisted endovenous ablation (MOCA) allow treatment of entire trunks with single anaesthetic injections. Previous non-randomised work has shown reduced pain post-operati...

    journal_title:Phlebology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/0268355516651026

    authors: Lane T,Bootun R,Dharmarajah B,Lim CS,Najem M,Renton S,Sritharan K,Davies AH

    更新日期:2017-03-01 00:00:00

  • Prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: a blinded sonographic evaluation.

    abstract:OBJECTIVES:To verify the prevalence of chronic cerebrospinal venous insufficiency in patients affected by different clinical forms of multiple sclerosis and in healthy subjects using the Zamboni ultrasound protocol combined with M-mode ultrasound examination. MATERIALS AND METHODS:We enrolled 112 patients with multipl...

    journal_title:Phlebology

    pub_type: 杂志文章

    doi:10.1177/0268355513512823

    authors: Tromba L,Blasi S,Vestri A,Kiltzanidi D,Tartaglia F,Redler A

    更新日期:2015-02-01 00:00:00