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NMR in target driven drug discovery: why not?

Abstract：

:No matter the source of compounds, drug discovery campaigns focused directly on the target are entirely dependent on a consistent stream of reliable data that reports on how a putative ligand interacts with the protein of interest. The data will derive from many sources including enzyme assays and many types of biophysical binding assays such as TR-FRET, SPR, thermophoresis and many others. Each method has its strengths and weaknesses, but none is as information rich and broadly applicable as NMR. Here we provide a number of examples of the utility of NMR for enabling and providing ongoing support for the early pre-clinical phase of small molecule drug discovery efforts. The examples have been selected for their usefulness in a commercial setting, with full understanding of the need for speed, cost-effectiveness and ease of implementation.

journal_name

J Biomol NMR

journal_title

Journal of biomolecular NMR

authors

Keiffer S,Carneiro MG,Hollander J,Kobayashi M,Pogoryelev D,Ab E,Theisgen S,Müller G,Siegal G

doi

10.1007/s10858-020-00343-9

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

521-529

issue

10-11

eissn

0925-2738

issn

1573-5001

pii

10.1007/s10858-020-00343-9

journal_volume

74

pub_type

杂志文章

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