Kinetic filtering of [(18)F]Fluorothymidine in positron emission tomography studies.

Abstract:

:[(18)F]Fluorothymidine (FLT) is a cell proliferation marker that undergoes predominantly hepatic metabolism and therefore shows a high level of accumulation in the liver, as well as in rapidly proliferating tumours. Furthermore, the tracer's uptake is substantial in other organs including the heart. We present a nonlinear kinetic filtering technique which enhances the visualization of tumours imaged with FLT positron emission tomography (FLT-PET). A classification algorithm to isolate cancerous tissue from healthy organs was developed and validated using 29 scan data from patients with locally advanced or metastatic breast cancer. A large reduction in signal from the liver and heart of 80% was observed following application of the kinetic filter, whilst the majority of signal from both primary tumours and metastases was retained. A scan acquisition time of 60 min has been shown to be sufficient to obtain the necessary kinetic data. The algorithm extends utility of FLT-PET imaging in oncology research.

journal_name

Phys Med Biol

authors

Gray KR,Contractor KB,Kenny LM,Al-Nahhas A,Shousha S,Stebbing J,Wasan HS,Coombes RC,Aboagye EO,Turkheimer FE,Rosso L

doi

10.1088/0031-9155/55/3/010

subject

Has Abstract

pub_date

2010-02-07 00:00:00

pages

695-709

issue

3

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(10)31475-8

journal_volume

55

pub_type

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