Abstract:
:[(18)F]Fluorothymidine (FLT) is a cell proliferation marker that undergoes predominantly hepatic metabolism and therefore shows a high level of accumulation in the liver, as well as in rapidly proliferating tumours. Furthermore, the tracer's uptake is substantial in other organs including the heart. We present a nonlinear kinetic filtering technique which enhances the visualization of tumours imaged with FLT positron emission tomography (FLT-PET). A classification algorithm to isolate cancerous tissue from healthy organs was developed and validated using 29 scan data from patients with locally advanced or metastatic breast cancer. A large reduction in signal from the liver and heart of 80% was observed following application of the kinetic filter, whilst the majority of signal from both primary tumours and metastases was retained. A scan acquisition time of 60 min has been shown to be sufficient to obtain the necessary kinetic data. The algorithm extends utility of FLT-PET imaging in oncology research.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Gray KR,Contractor KB,Kenny LM,Al-Nahhas A,Shousha S,Stebbing J,Wasan HS,Coombes RC,Aboagye EO,Turkheimer FE,Rosso Ldoi
10.1088/0031-9155/55/3/010subject
Has Abstractpub_date
2010-02-07 00:00:00pages
695-709issue
3eissn
0031-9155issn
1361-6560pii
S0031-9155(10)31475-8journal_volume
55pub_type
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