Primary peritoneal cancer after bilateral salpingo-oophorectomy in two patients with Lynch syndrome.

Abstract:

BACKGROUND:Women with Lynch syndrome or hereditary nonpolyposis colorectal carcinoma (HNPCC) have a 40-60% lifetime risk of endometrial cancer and a 7-12% lifetime risk of ovarian cancer. Risk-reducing surgery, including hysterectomy and bilateral salpingo-oophorectomy (BSO), is currently recommended once child bearing is complete. We describe two cases of primary peritoneal cancer after BSO in women with Lynch syndrome or HNPCC. CASES:The first patient was a 44-year-old woman who underwent hysterectomy with BSO for benign disease. She presented 12 years later with a pelvic mass and was diagnosed with a high-grade serous primary peritoneal cancer. Genetic testing showed a mutation in the MSH2 DNA mismatch repair gene. The second case was a 58-year-old woman who had a hysterectomy and BSO for endometrial cancer. She developed a high-grade serous primary peritoneal cancer 8 years later and was found to have a mutation in the PMS2 DNA mismatch repair gene. CONCLUSION:Women with Lynch syndrome or HNPCC should be counseled that they may be at risk for developing primary peritoneal cancer despite undergoing gynecologic cancer risk-reducing surgery. The magnitude of this risk remains to be determined.

journal_name

Obstet Gynecol

authors

Schmeler KM,Daniels MS,Soliman PT,Broaddus RR,Deavers MT,Vu TM,Chang GJ,Lu KH

doi

10.1097/AOG.0b013e3181b6f4f9

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

432-434

issue

2 Pt 2

eissn

0029-7844

issn

1873-233X

pii

00006250-201002001-00014

journal_volume

115

pub_type

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