Abstract:
INTRODUCTION:We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia. METHODS:One hundred twenty subjects with clinical follow-up of at least 1 year with two scans were selected from a cognitive disorders clinic. Scans were reviewed as a single first scan (method A), two unregistered scans presented side-by-side (method B) and a registered pair (method C). Scans were presented to two neuroradiologists and a clinician together with approximate scan interval (if applicable) and age. Raters decided on a main and subtype diagnosis. RESULTS:There was no evidence that differences between methods (expressed as relative odds of a correct response) differed between reviewers (p = 0.17 for degenerative condition or not, p = 0.5 for main diagnosis, p = 0.16 for subtype). Accordingly, results were pooled over reviewers. For distinguishing normal/non-progressors from degenerative conditions, the proportions correctly diagnosed were higher with methods B and C than with A (p = 0.001, both tests). The difference between method B and C was not statistically significant (p = 0.18). For main diagnosis, the proportion of correct diagnoses were highest with method C for all three reviewers; however, this was not statistically significant comparing with method A (p = 0.23) or with method B (p = 0.16). For subtype diagnosis, there was some evidence that method C was better than method A (p = 0.01) and B (p = 0.048). CONCLUSIONS:Serial MRI and registration may improve visual diagnosis in dementia.
journal_name
Neuroradiologyjournal_title
Neuroradiologyauthors
Barnes J,Mitchell LA,Kennedy J,Bastos-Leite AJ,Barker S,Lehmann M,Nordstrom RC,Frost C,Smith JR,Garde E,Rossor MN,Fox NCdoi
10.1007/s00234-010-0665-xsubject
Has Abstractpub_date
2010-11-01 00:00:00pages
987-95issue
11eissn
0028-3940issn
1432-1920journal_volume
52pub_type
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