MRI of autosomal dominant pure spastic paraplegia.

Abstract:

:We examined 16 patients with autosomal dominant pure spastic paraplegia (HSP) and 15 normal controls matched for age and sex using MRI of the brain and spinal cord. Images were assessed qualitatively by two independent radiologists, blinded to the clinical diagnosis. Areas of the brain and corpus callosum on one midsagittal slice and the area of the brain on one axial slice were measured and a "corpus-callosum index" expressing the size of the corpus callosum relative to that of the brain was calculated. Cross-sectional areas and anteroposterior and transverse diameters of the spinal cord at the levels of C 2, C 5, T 3, T 6, T 9 and T 11 were measured. No significant differences between patients and controls were found on qualitative evaluation of the images. The patients had a significantly smaller corpus callosum and "corpus-callosum index" than controls. This finding, not reported previously, might indicate that the disease process in pure HSP is not confined to the spinal cord. The anteroposterior diameters of the spinal cord at T 3 and T 9 were significantly smaller in patients than in controls. This might correspond to the degeneration of the pyramidal tracts and the dorsal columns described at neuropathological examination.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Krabbe K,Nielsen JE,Fallentin E,Fenger K,Herning M

doi

10.1007/s002340050495

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

724-7

issue

10

eissn

0028-3940

issn

1432-1920

journal_volume

39

pub_type

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