Abstract:
PURPOSE OF REVIEW:To describe the path of technological developments that have led to the actual application of MRI-guided focused ultrasound in multiple neurological disorders and to update the more recent technical advances in the field. An insight into the latest clinical achievements in movement disorders will be provided, together with the neuroimaging advances for the screening, planning, and outcome evaluation. RECENT FINDINGS:Developments, such as phased array transducers and MRI guidance have allowed the use of focused ultrasound to successfully perform incisionless therapeutic ablation in deep brain structures. Although its indication through a thalamotomy has been approved for essential and parkinsonian tremor, it has also shown preliminary efficacy for other types of tremor, Parkinson's disease motor signs and neuropsychiatric disorders. In parallel, neuroradiological techniques have helped to improve treatment application and provided new evidence in terms of lesion topography, impact on distant structures and understanding of action mechanisms. SUMMARY:Neuroimaging developments have helped to increase successful applications of focused ultrasound as a minimally invasive ablative approach and to understand the mechanisms by which ablation of a certain brain region improves neurological disorders. The field is expanding rapidly and in the coming years it will transform functional neurosurgery.
journal_name
Curr Opin Neuroljournal_title
Current opinion in neurologyauthors
Martínez-Fernández R,Pineda-Pardo JAdoi
10.1097/WCO.0000000000000840subject
Has Abstractpub_date
2020-08-01 00:00:00pages
488-497issue
4eissn
1350-7540issn
1473-6551pii
00019052-202008000-00010journal_volume
33pub_type
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