Abstract:
INTRODUCTION:The purpose of this study was to explore the effectiveness of two chitosan formulations, Omni-Stat® granules and Celox Gauze®, in a model of major hepatic injury in the presence of clotting dysfunction. MATERIALS AND METHODS:Major hepatic injuries in moderately heparinised swine were treated with either Omni-Stat® granules or Celox Gauze® as compared to control plain gauze. RESULTS:Plain gauze control failed to stop the bleeding in 13 of 14 attempts. Omni-Stat® arrested the bleeding in 18 of 18 attempts, providing it was in contact with the bleeding surface. Celox Gauze® arrested bleeding in 5 out of 6 attempts initially, and with further pressure in the sixth. CONCLUSIONS:The results support the evidence that chitosan-derived products act independently of classical clotting pathways and should be effective in patients who suffer major liver injury even in the presence of clotting dysfunctions.
journal_name
Ann R Coll Surg Engljournal_title
Annals of the Royal College of Surgeons of Englandauthors
Millner R,Lockhart AS,Marr Rdoi
10.1308/003588410X12699663903593subject
Has Abstractpub_date
2010-10-01 00:00:00pages
559-61issue
7eissn
0035-8843issn
1478-7083pii
58journal_volume
92pub_type
杂志文章abstract::The most important development in determining successful organ transplantation has been the improved understanding of the immune response and the interactions between antigens, antibody, immune complexes, complement component, lymphocytes and macrophages. The initiation and termination of an immune response, whether c...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章,评审
doi:
更新日期:1983-05-01 00:00:00
abstract::BACKGROUND Arthroscopy is the established 'gold standard' diagnostic investigation for detection of shoulder disorders. We aimed to compare the diagnostic accuracy of arthroscopy with magnetic resonance arthrography (MRA) for detection of shoulder disorders. METHODS Patients who underwent arthroscopy by a single surge...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/rcsann.2016.0249
更新日期:2017-04-01 00:00:00
abstract::Gastric spiral organisms were first described in man in 1939 and identified as Helicobacter pylori causing peptic ulcers in the early 1980s. Surgical specimens of gastric resections from 1939 showed H. pylori to be present. Full-thickness sections of gastric mucosa from gastric specimens from the eighteenth-century Hu...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 历史文章,杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::While some degree of specialization is essential in surgery there remains a place for the general surgeon. The tendency to regard surgical intensive care as a specialty should be resisted. Similarly the surgery of trauma should remain in the field of the general surgeon in full co-operation with the orthopaedic surgeo...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:1975-09-01 00:00:00
abstract::The collection of data for audit and clinical activity analysis is time consuming. This report outlines a technique by which data held on hospital data systems, such as the PAS and theatre management systems, can be made available to clinical investigators. The saving in time and effort can be enormous. ...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::Scintigraphy was performed on 180 patients with suspected biliary tract disease using technetium-99m-labelled derivatives of iminodiacetic acid. Most of the patients were also evaluated by conventional techniques and the results were correlated with the findings at operation and with histological examination of tissue...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:1981-09-01 00:00:00
abstract::We describe three cases that presented with symptoms suggestive of appendicitis but were found at operation to have an inflamed solitary caecal diverticulum. All were treated successfully with diverticulectomy or inversion of the diverticulum. We wish to highlight this diagnosis and its surgical management so that inf...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/003588406X149336
更新日期:2006-11-01 00:00:00
abstract::This case report details an unusual, but preventable, error in surgical site marking. ...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/147870809X400859
更新日期:2009-03-01 00:00:00
abstract::Six patients are reported who presented with perforated duodenal ulcers. These were repaired laparoscopically by suturing the falciform ligament over the perforated ulcer. There were no complications and patients were discharged between 3 and 5 days after surgery. This technique is simpler to perform than a laparoscop...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::A 77-year-old man had aorto-iliac bypass for an abdominal aortic aneurysm (AAA). This was complicated by occlusion that needed extension of the graft to the right femoral artery. He was unable to move his right leg with numbness after surgery. This was caused by extensive lumbosacral plexopathy on the right side. Lumb...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章,评审
doi:10.1308/147870807X188470
更新日期:2007-07-01 00:00:00
abstract:INTRODUCTION:Complications of epidural catheterisation can cause significant morbidity. Epidural abscess following epidural catheterisation is rare and the reported incidence is variable. The purpose of this study was to review the incidence of epidural abscess in patients undergoing open abdominal aortic aneurysm (AAA...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/003588410X12518836438886
更新日期:2010-01-01 00:00:00
abstract::Pseudoaneurysm is a rare complication of surgery or trauma around the knee. A 30-year-old man presented 10 days following anterior cruciate ligament repair with a 2 cm pulsatile swelling on the medial side of the knee. Angiography demonstrated a pseudoaneurysm of the medial inferior genicular artery. Surgical explorat...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract::Two patients undergoing inguinal herniorrhaphy developed transient quadriceps paresis after local inguinal nerve block. One sustained a compound fracture of the distal tibia and fibula. The importance of warning the patient and of increasing the awareness of nursing staff to the possibility of quadriceps weakness afte...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::We present the case of a 27-year-old man who underwent percutaneous atrial septal defect (ASD) repair using the Amplatzer(®) (St Jude Medical, St Paul, MN, US) septal occluder (ASO). Six weeks later, he presented with heart failure and was found to have an aorto-right atrial fistulation. He required urgent surgical de...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/003588414X13814021679591
更新日期:2014-07-01 00:00:00
abstract::The brachial plexus is related intimately to the clavicle such that injury can occur primarily and most commonly at the time of trauma through traction or it can occur secondarily, mainly owing to hypertrophic non-union with exuberant callus formation, causing compression of the plexus. The movement-dependent rearrang...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/003588413X13511609956174
更新日期:2013-04-01 00:00:00
abstract::Although the operating microscope was introduced more than 50 years ago, its use was at first confined to otolaryngology and, later, to ophthalmology. More recently its use in the development of microvascular techniques has led to spectacular advances in the field of replantation and reconstructive surgery. The organi...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 历史文章,杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract::Carcinoma of the oral cavity occurring in Africans is poorly documented. Although oral cancer is considered rare in Africa approximately 40 cases of intraoral carcinoma are seen yearly at the Maxillofacial Clinic, Kaduna. This paper reviews 137 cases of malignant disease in the oral cavity and compares the results wit...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract:INTRODUCTION:Suspected testicular torsion (TT) is a surgical emergency, usually requiring urgent scrotal exploration. Provision of urology on-call cover varies widely between hospitals and often falls under the remit of the general surgical team. The purpose of this study was to investigate whether the management of su...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章,多中心研究
doi:10.1308/003588410X12771863937007
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to develop a standardised management plan for boys with abnormal appearance of meatus at circumcision for balanitis xerotica obliterans (BXO). METHODS:Between 1995 and 2008, 107 boys underwent circumcision for BXO (confirmed on histology). Of these, 23 had abnormal appearance of ...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/003588411X587145
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate the degree of contamination of a surgeon's hand following use of chlorhexidine gluconate or alcohol gel as disinfectants. MATERIALS AND METHODS:In this prospective, randomised trial, orthopaedic surgeons were allocated to one of two different hand-washing protocols...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章,随机对照试验
doi:10.1308/003588406X83032
更新日期:2006-01-01 00:00:00
abstract::Objective This study assessed primary urethral reconstruction results in patients with a penile fracture. Materials and methods Between January 2005 and April 2016, patients who underwent primary urethral reconstruction due to penile fracture were called for a follow-up. Epidemiological and clinical presentation data ...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/rcsann.2017.0098
更新日期:2018-01-01 00:00:00
abstract::Over the past 15 years, 32 cases of tuberculosis have been seen and diagnosed in the surgical and gynaecological departments of the Northern General Hospital, Sheffield. The average age of patients was 42.8 years. Of the sites affected, 17 had head, neck or axillary swellings, 6 affected the female genital tract, 3 ha...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
abstract::Extraskeletal Ewing sarcoma (EES) is a rare soft tissue neoplasm of primitive mesenchymal cells. There is a scarcity of data on EES involving the head and neck, with studies being over years or even decades. We are the first to report a case of EES involving the carotid artery and its subsequent surgical excision and ...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章,评审
doi:10.1308/003588412X13171221501348
更新日期:2012-05-01 00:00:00
abstract::The results of the secretin-pancreozymin test, duodenal aspirate cytology and hypotonic duodenography (the Triple Test), performed during a single duodenal intubation in patients with pancreatic or ampullary carcinoma, chronic pancreatitis and non-pancreatic disease were analysed retrospectively. Thirty-five of 36 car...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:
更新日期:1983-05-01 00:00:00
abstract::We report a patient with ulcerative colitis who, in the period following surgery, developed recurrent episodes of acute adrenal insufficiency presenting clinically as a high output ileostomy. ...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/003588403321219876
更新日期:2003-03-01 00:00:00
abstract::We present a case of massive pneumoperitoneum in association with pneumatosis intestinalis that was successfully managed without surgery despite a clinical picture of an acute abdomen and biochemical evidence of inflammation and systemic upset. Recognition of non-surgical pneumoperitoneum is important to avoid unneces...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/147870808X257193
更新日期:2008-03-01 00:00:00
abstract::Injuries to the nose can be severe from both a functional and cosmetic perspective. After suffering a dog bite to the central part of the face, an 18-year old woman underwent replantation of the avulsed tissue with the help of microsurgical arterial anastomosis. A venous anastomosis was impossible and venous congestio...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/rcsann.2016.0026
更新日期:2016-02-01 00:00:00
abstract::This is a case of a very unusual cause of an acute groin lump in a 71-year-old woman that was presumed initially to either be an incisional or inguinal hernia. However, with subsequent computed tomography it was shown to be thrombophlebitis of collateral vessels secondary to a previous deep vein thrombosis. This case...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/003588412X13171221499063
更新日期:2012-01-01 00:00:00
abstract:AIM:To describe 19th century amputations carried out at the Royal Berkshire Hospital, Reading. METHODS:A retrospective analysis of hospital archives. RESULTS:Details of 276 amputations were analysed. The majority (86%) were in men and boys. The median age was 33 years. The ratio of leg:arm amputation was 2:1. Trauma ...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 历史文章,杂志文章
doi:10.1308/003588403322520753
更新日期:2003-11-01 00:00:00
abstract:INTRODUCTION:The diagnostic performance of ultrasound-fine needle aspiration to identify thyroid nodules harbouring malignancy remains variable. The aim of this study was to determine thyroid nodule size and cytological classification as predictors of malignancy risk. MATERIALS AND METHODS:We conducted a retrospective...
journal_title:Annals of the Royal College of Surgeons of England
pub_type: 杂志文章
doi:10.1308/rcsann.2019.0156
更新日期:2020-01-01 00:00:00