Chitosan arrests bleeding in major hepatic injuries with clotting dysfunction: an in vivo experimental study in a model of hepatic injury in the presence of moderate systemic heparinisation.

Abstract:

INTRODUCTION:The purpose of this study was to explore the effectiveness of two chitosan formulations, Omni-Stat® granules and Celox Gauze®, in a model of major hepatic injury in the presence of clotting dysfunction. MATERIALS AND METHODS:Major hepatic injuries in moderately heparinised swine were treated with either Omni-Stat® granules or Celox Gauze® as compared to control plain gauze. RESULTS:Plain gauze control failed to stop the bleeding in 13 of 14 attempts. Omni-Stat® arrested the bleeding in 18 of 18 attempts, providing it was in contact with the bleeding surface. Celox Gauze® arrested bleeding in 5 out of 6 attempts initially, and with further pressure in the sixth. CONCLUSIONS:The results support the evidence that chitosan-derived products act independently of classical clotting pathways and should be effective in patients who suffer major liver injury even in the presence of clotting dysfunctions.

journal_name

Ann R Coll Surg Engl

authors

Millner R,Lockhart AS,Marr R

doi

10.1308/003588410X12699663903593

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

559-61

issue

7

eissn

0035-8843

issn

1478-7083

pii

58

journal_volume

92

pub_type

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