Abstract:
:Biological products of importance in food (e.g., milk) and medical (e.g., donor blood-derived products) sciences often correspond to mixtures of samples contributed by multiple individuals. Identifying which individuals contributed to the mixture and in what proportions may be of interest in several circumstances. We herein present a method that allows to do this by shallow whole-genome sequencing of the DNA in mixed samples from hundreds of donors. We show the efficacy of the approach for the detection of cows with subclinical mastitis by analysis of farms' tank mixtures containing milk from as many as 500 cows.
journal_name
Genome Resjournal_title
Genome researchauthors
Coppieters W,Karim L,Georges Mdoi
10.1101/gr.256172.119subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1201-1207issue
8eissn
1088-9051issn
1549-5469pii
gr.256172.119journal_volume
30pub_type
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