Integrative approaches to treating pain in sickle cell disease: Pre-clinical and clinical evidence.

Abstract:

:Sickle cell disease (SCD) is a genetic disorder characterized by hemolysis, end-organ damage, inflammation, and pain. Recurrent and unpredictable episodes of acute pain due to vaso-occlusive crises are a unique feature of SCD. Many patients also develop lifelong chronic pain. Opioids are the primary method of pain treatment in SCD; however, continued use is associated with several adverse effects. Integrative approaches to treating pain in SCD are increasingly being explored to prevent the side effects associated with opioids. In this review, we highlight the mechanisms of pain in SCD and describe mechanism-based integrative approaches for treating pain.

journal_name

Complement Ther Med

authors

Sagi V,Argueta DA,Kiven S,Gupta K

doi

10.1016/j.ctim.2020.102394

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

102394

eissn

0965-2299

issn

1873-6963

pii

S0965-2299(20)30624-5

journal_volume

51

pub_type

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    authors: Smith CA,Betts D

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