Abstract:
:Glycoproteins are a major class of glycoconjugates displaying a variety of mutual interactions between glycan and protein moieties that ultimately affect molecular organization. Modulation of the pendant glycan structures is important in tuning the functions of glycoproteins. Here we discuss structural aspects and some of the challenges to studying intramolecular interactions between carbohydrate and protein elements in several forms of O-linked as well as N-linked glycoproteins. These illustrate the importance of the relationship of context to function in protein glycosylation.
journal_name
Methods Enzymoljournal_title
Methods in enzymologyauthors
Barb AW,Borgert AJ,Liu M,Barany G,Live Ddoi
10.1016/S0076-6879(10)78018-6subject
Has Abstractpub_date
2010-01-01 00:00:00pages
365-88eissn
0076-6879issn
1557-7988pii
S0076-6879(10)78018-6journal_volume
478pub_type
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