Positive Crossmatch Kidney Transplantation: State of the Art and Future Perspectives.

abstract：:Macrophages are professional scavengers of apoptotic and necrotic cells, and hence constantly take up self antigens. Paradoxically, macrophages are also professional antigen-presenting cells, which would seem to invite autoimmune disorders. Moreover, macrophages are effector cells in the tissue-destruction phase of au...

journal_title：Current pharmaceutical design

authors： Munn DH,Mellor AL

更新日期：2003-01-01 00:00:00

abstract：:Cancer therapies through ionizing radiation or chemotherapeutic treatment may result in DNA double strand breaks (DSBs) in cell. DNA-PK has emerged as an attractive target for drug discovery efforts toward DSBs repair and in V(D)J recombination. Hence, the search for potent and selective DNA-PK inhibitors has received...

journal_title：Current pharmaceutical design

authors： Cao R,Zeng H,Zhang H

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a global epidemic involving 20-40% of the general population. NAFLD is rapidly becoming the leading cause of hepatocellular carcinoma (HCC) worldwide. Knowledge about NAFLD-HCC peculiar features is needed to understand this emerging disease better. OBJECTIVE:To r...

journal_title：Current pharmaceutical design

authors： Tovoli F,Ferri S,Piscaglia F

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Mitochondria are cellular organelles responsible for energy production, calcium handling, controlled synthesis of reactive oxygen species (ROS), and regulation of apoptosis. All these functions are crucial for cardiac homeostasis, and may be impaired in chronic heart failure (CHF). Therefore, mitochondrial d...

journal_title：Current pharmaceutical design

authors： Aimo A,Borrelli C,Vergaro G,Piepoli MF,Caterina AR,Mirizzi G,Valleggi A,Raglianti V,Passino C,Emdin M,Giannoni A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Breast cancer is one of the leading cancers in women in the Western world. Cancer treatment, especially chemotherapy, is often associated with physical and psychosocial side effects. OBJECTIVE:To improve the quality of life and manage side effects, a new integrative mind-body-medicine group concept for brea...

journal_title：Current pharmaceutical design

authors： Haller H,Choi KE,Lange S,Kümmel S,Paul A,Cramer H,Dobos G,Voiss P

更新日期：2020-12-10 00:00:00

abstract：:Arterial thromboembolism is a sudden obstruction of arterial blood flow caused by dislodgment of a blood clot from the site of its formation. Atrial fibrillation (AF) is the most common cardiac arrhythmia and a major risk factor for arterial thromboembolism in clinical practice. Most of AF-related arterial thromboembo...

journal_title：Current pharmaceutical design

authors： Potpara TS,Lip GY

更新日期：2010-01-01 00:00:00

abstract：:Naturally occurring and chemically modified ribonucleosides have interesting bioactive effects. Dietary ribonucleosides are ingested mainly as nucleoproteins and are converted in the course of intestinal digestion to monomeric compounds. Different bioactive effects of dietary ribonucleosides have been described, inclu...

journal_title：Current pharmaceutical design

authors： Martin D,Meisel H

更新日期：2007-01-01 00:00:00

abstract：:Estrogens are known as important modulators of development, growth and maintenance of primary sexual physiology. The medical field has also grown increasingly appreciative of the effects of estrogens on non-traditional target tissues such as bone, cardiovascular tissue and the CNS. Postmenopausal women have been the b...

journal_title：Current pharmaceutical design

authors： Miller CP

更新日期：2002-01-01 00:00:00

abstract：:DAP12 is a novel immunoreceptor tyrosine-based activation motifs (ITAM)-bearing transmembrane adapter molecule. This molecule, together with its partner receptor complex molecules including the killer cell activating receptors (KARs), myeloid DAP12 associating lectin-1 (MDL-1), triggering receptor expressed on myeloid...

journal_title：Current pharmaceutical design

authors： Aoki N,Kimura S,Xing Z

更新日期：2003-01-01 00:00:00

abstract：:Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled membrane receptors of the P2Y family. Four distinct pyrimidine nucleotide-sensitive P2Y receptor subtypes have been cloned, P2Y(2), P2Y(4), P2Y(6) and P2Y(14). Pharmacological experiments indi...

journal_title：Current pharmaceutical design

authors： Müller CE

更新日期：2002-01-01 00:00:00

abstract：:In the third millennium preventive medicine is becoming a corner stone in our concept of health. Colorectal cancer (CRC) fits the criteria of a disease suitable for prevention interventions. It is a prevalent disease that is associated with considerable mortality and morbidity rates, with more than 1,000,000 new cases...

journal_title：Current pharmaceutical design

authors： Boursi B,Arber N

更新日期：2007-01-01 00:00:00

abstract：:LIM (Lin-11, Isl-1, Mec-3), RING (Really interesting new gene), PHD (Plant homology domain) and MYND (myeloid, Nervy, DEAF-1) domains are all zinc-binding domains that ligate two zinc ions. Unlike the better known classical zinc fingers, these domains do not bind DNA, but instead mediate interactions with other protei...

journal_title：Current pharmaceutical design

authors： Matthews JM,Bhati M,Lehtomaki E,Mansfield RE,Cubeddu L,Mackay JP

更新日期：2009-01-01 00:00:00

abstract：:In this review we discuss the role of protonation states in receptor-ligand interactions, providing experimental evidences and computational predictions that complex formation may involve titratable groups with unusual pKa's and that protonation states frequently change from unbound to bound states. These protonation ...

journal_title：Current pharmaceutical design

authors： Petukh M,Stefl S,Alexov E

更新日期：2013-01-01 00:00:00

abstract：:Gene therapy, currently, represents one of the new therapies that have emerged for the treatment of different diseases. Between the different approaches that can be chosen concerning this therapy, gene delivery with non-viral systems has focused the attention during the past decades, because of the reduced toxicity co...

journal_title：Current pharmaceutical design

authors： Urbiola K,Blanco-Fernandez L,de Ilarduya CT

更新日期：2015-01-01 00:00:00

abstract：:Circumstantial evidence has been provided of a role of the plasminogen/plasmin system in a variety of biological phenomena, including thrombolysis, vascular stenosis, reproduction, embryogenesis, cell invasion, angiogenesis, brain function and chronic lung or kidney inflammatory disorders. Inhibition of the system occ...

journal_title：Current pharmaceutical design

authors： Matsuno H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Drugs acting on the cardiovascular and central nervous system often display relatively fast clinical responses, which may differ in neonates compared to children and adults. Introduction of bedside monitoring tools might be of additional value in the pharmacodynamic (PD) assessment of such drugs in neonates....

journal_title：Current pharmaceutical design

authors： Smits A,Thewissen L,Dereymaeker A,Dempsey E,Caicedo A,Naulaers G

更新日期：2017-01-01 00:00:00

abstract：:Gonadotropin Releasing Hormone (GnRH) is at the centre of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH are mainly congenital and may or may not be associated with other genetic anomalies or syndromes. Cli...

journal_title：Current pharmaceutical design

authors： Bettocchi C,Rinaldi M,Sebastiani F

更新日期：2020-11-24 00:00:00

abstract：:Myocarditis is a disease whose pathogenesis is not completely understood and whose prevalence is likely underestimated. Individuals afflicted with this condition may be treated with agents that relieve symptoms arising from inflammation and concurrent cellular damage. One class of drugs commonly used in the treatment ...

journal_title：Current pharmaceutical design

authors： Godsel LM,Leon JS,Engman DM

更新日期：2003-01-01 00:00:00

abstract：:Schizophrenia is a complex psychiatric disorder characterised by positive and negative symptoms, cognitive impairments, attentional problems, anxiety and depressive symptoms. The use of atypical antipsychotics has generally improved clinical outcome yet medical need remains in the treatment of this disease. The potent...

journal_title：Current pharmaceutical design

authors： McCreary AC,Jones CA

更新日期：2010-01-01 00:00:00

abstract：:Treatment of chronic lymphocytic leukemia (CLL) has recently undergone revolutionary changes. Two large randomized trials demonstrated superiority of chemoimmunotherapy combining fludarabine and cyclophosphamide with monoclonal anti-CD20 antibody rituximab (FCR) over fludarabine and cyclophosphamide (FC) alone in firs...

journal_title：Current pharmaceutical design

authors： Smolej L

更新日期：2012-01-01 00:00:00

abstract：:A new controlled delivery system has been developed for ropinirole (RP) for the treatment of Parkinson´s Disease (PD) consisting in PLGA microparticles (MPs) which exhibited in vitro constant release of RP (78.23 µg/day/10 mg MPs) for 19 days. The neuroprotective effects of RP released from MPs were evaluated in SKN-A...

journal_title：Current pharmaceutical design

authors： Negro S,Boeva L,Slowing K,Fernandez-Carballido A,Garcia-García L,Barcia E

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Vagal nerve plays an important role in the stomach function. The cholinergic nerves are the most abundantly distributed nerves in the gastric tissue. It has recently been reported that the vagal nerve is significantly related to both gastric cancer development and progression. However, its relation to the me...

journal_title：Current pharmaceutical design

authors： Kodama Y,Sasaki K,Murasato F,Overby A,Takahashi S,Murayama SY,Matsui H,Nakamura M

更新日期：2018-01-01 00:00:00

abstract：:Microdialysis is a technique for sampling the chemistry of the interstitial fluid of tissues and organs in animal and man. It is minimally invasive and simple to perform in a clinical setting. Although microdialysis samples essentially all small molecular substances present in the interstitial fluid the use of microdi...

journal_title：Current pharmaceutical design

authors： Ungerstedt U,Rostami E

更新日期：2004-01-01 00:00:00

abstract：BACKGROUNDS:Targeted therapy is the foundation of personalized medicine in cancer, which is often understood as the right patient using the right drug. Thinking from the viewpoint of determinants during personalized drug treatment, the genetics, epigenetics and metagenomics would provide individual-specific biological ...

journal_title：Current pharmaceutical design

authors： Wang L,Yu X,Zhang C,Zeng T

更新日期：2018-01-01 00:00:00

abstract：:Regulatory T lymphocytes (Tregs) are specialized for immune suppression and are important regulators of the immune response in various settings. Tregs actively suppress enteroantigen-reactive cells and contribute to the maintenance of intestinal immune homeostasis. Distinct Treg subsets coexist in the intestinal mucos...

journal_title：Current pharmaceutical design

authors： Mizrahi M,Ilan Y

更新日期：2009-01-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) remains the single biggest challenge in infectious disease in the civilized world. Moreover, vancomycin resistance is also spreading, leading to fears of untreatable infections as were common in ancient times. Molecular microbiology and bioinformatics have revealed ma...

journal_title：Current pharmaceutical design

authors： Magana M,Ioannidis A,Magiorkinis E,Ursu O,Bologa CG,Chatzipanagiotou S,Hamblin MR,Tegos GP

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The application of an ion selective technique for the determination of analyte concentrations is considered one of the most economical techniques for quality control purposes. OBJECTIVE:To elaborate and investigate the construction and general performance characteristics of potentiometric PVC membrane senso...

journal_title：Current pharmaceutical design

authors： Mansour MF,El-Moety MMA,El Kady EF,El Guindi NM,Schepdael AV,Aly SME

更新日期：2018-01-01 00:00:00

abstract：:Donkey's milk is the best substitute of human milk for its content in lactose, proteins, minerals, and omega-3 fatty acids. Here, we have evaluated the effects of colostrum and milk from donkeys (Martina Franca breed) on the function of human peripheral blood mononuclear cells (PBMCs) at different intervals from lacta...

journal_title：Current pharmaceutical design

authors： Tafaro A,Magrone T,Jirillo F,Martemucci G,D'Alessandro AG,Amati L,Jirillo E

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:A mobile health application is an exciting, fast-paced domain that is likely to improve prenatal care. METHODS:In this narrative review, we summarise the use of mobile health applications in this setting with a special emphasis on both the benefits of remote monitoring devices and the potential pitfalls of ...

journal_title：Current pharmaceutical design

authors： Gyselaers W,Lanssens D,Perry H,Khalil A

更新日期：2019-01-01 00:00:00

abstract：:The majority of pharmaceutical formulations for the treatment of ocular pathologies are for topical administration. However, this kind of ophthalmic formulations has disadvantages such as low bioavailability and, consequently, a reduced therapeutic effect. This happens due to the anatomical and physiological specifici...

journal_title：Current pharmaceutical design

authors： Almeida H,Amaral MH,Lobao P,Frigerio C,Sousa Lobo JM

更新日期：2015-01-01 00:00:00