Antipsychotic medication: the potential role of 5-HT(1A) receptor agonism.

abstract：:Neuroinflammation is a common characteristic of several mental health conditions such as major depression, bipolar disorder, post-traumatic stress disorder (PTSD) and schizophrenia (SCHZ). Inflammatory processes trigger and/or further deteriorate mental functions and are regarded as targets for therapeutic drug develo...

journal_title：Current pharmaceutical design

authors： Echeverria V,Grizzell JA,Barreto GE

更新日期：2016-01-01 00:00:00

abstract：:There is an increased use of oral anticoagulants for the prevention of venous and arterial thrombosis. Vitamin-K antagonists have been used for decades as the main oral anticoagulants but they have the draback a complex therapeutic management, slow onset of action and by a different oral intake caused by dietary vitam...

journal_title：Current pharmaceutical design

authors： Lamperti M,Khozenko A,Kumar A

更新日期：2019-01-01 00:00:00

abstract：:Plasma concentrations of phytosterols and non-cholesterol sterol precursors of cholesterol synthesis have been used as markers of intestinal cholesterol absorption and synthesis in inherited and secondary dyslipidemias and in population-based investigations to evaluate the risk for cardiovascular disease, respectively...

journal_title：Current pharmaceutical design

authors： Quintão ECR

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cancer and its treatment therapies, such as chemotherapy and radiotherapy, have negative effects on taste and smell functions. It is easy to explain smell and taste dysfunctions when a cancer involves the peripheric end organs or neurologic pathways of smell and taste. However, it is difficult to understand ...

journal_title：Current pharmaceutical design

authors： Altundag A,Cayonu M

更新日期：2016-01-01 00:00:00

abstract：:Mechanical loading provides an anabolic stimulus for bone. More importantly, the mechanosensing apparatus in bone directs osteogenesis to where it is most needed for improving bone strength. The biological processes involved in bone mechanotransduction are poorly understood and further investigation of the molecular m...

journal_title：Current pharmaceutical design

authors： Turner CH,Robling AG

更新日期：2004-01-01 00:00:00

abstract：:The rise of multi-drug resistant and extensively drug resistant M. tuberculosis around the world poses a great threat to human health, and necessitates development of new, effective and inexpensive anti-tubercular agents. The availability of knowledge on molecular biology of M. tuberculosis infection coupled with whol...

journal_title：Current pharmaceutical design

authors： Chauhan RS,Chanumolu SK,Rout C,Shrivastava R

更新日期：2014-01-01 00:00:00

abstract：:Phase-change contrast agents (PCCAs) for ultrasound-based applications have resulted in novel ways of approaching diagnostic and therapeutic techniques beyond what is possible with microbubble contrast agents and liquid emulsions. When subjected to sufficient pressures delivered by an ultrasound transducer, stabilized...

journal_title：Current pharmaceutical design

authors： Sheeran PS,Dayton PA

更新日期：2012-01-01 00:00:00

abstract：:Sulphur mustard (SM; (2, 2'-dichloroethylsulfide)) was used for the first time in 1917, during the World War I. SM mainly induces DNA damage, oxidative stress, and inflammation. This compound injures the respiratory system, eyes, skin and the endocrine, gastrointestinal, and hematopoietic systems. However, due to the ...

journal_title：Current pharmaceutical design

authors： Panahi Y,Shahbazi A,Naderi M,Jadidi K,Sahebkar A

更新日期：2018-01-01 00:00:00

abstract：:CHD is one of the most common serious chronic conditions in postmenopausal women and leads to extremely high risk for recurrent myocardial infarction and death. On the basis of the currently available randomized clinical-trial results the role of conventional HRT for treatment and prevention of CHD is rapidly evolving...

journal_title：Current pharmaceutical design

authors： Francucci CM,Camilletti A,Boscaro M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Cyclodextrins (CDs), as one type of the novel pharmaceutical excipients, have been widely used in drug delivery and pharmaceutical industry. Over the past decades, a large amount of molecular modeling studies in CDs were reported for profound understanding of structural, dynamic and energetic features of CDs...

journal_title：Current pharmaceutical design

authors： Zhao Q,Zhang W,Wang R,Wang Y,Ouyang D

更新日期：2017-01-01 00:00:00

abstract：:Cell therapy has been proposed to treat patients with end-stage heart failure. However, it has been suggested that the significant mechanical forces in an often ischaemic, inflamed, biochemically hostile environment may cause poor cell survival and retention. It is hypothesised that tissue engineering techniques could...

journal_title：Current pharmaceutical design

authors： Rao C,Barratt H,Prodromakis T,Terracciano CM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Erectile dysfunction (ED) is an evolving health problem in the aging male population. Chronic low-grade inflammation is a critical component of ED pathogenesis and a probable intermediate stage of endothelial dysfunction, especially in metabolic diseases, with the inclusion of obesity, metabolic syndrome, an...

journal_title：Current pharmaceutical design

authors： Kaya-Sezginer E,Gur S

更新日期：2020-01-01 00:00:00

abstract：:NAP (davunetide) is an eight amino acid peptide (NAPVSIPQ) that has been shown to provide potent neuroprotection, in vitro and in vivo. In human clinical trials, NAP has been shown to increase memory scores in patients suffering from amnestic mild cognitive impairment, a precursor to Alzheimer's disease and to enhance...

journal_title：Current pharmaceutical design

authors： Gozes I

更新日期：2011-01-01 00:00:00

abstract：:Although the obesity epidemic is constantly expanding at very high costs for health care systems, the currently available options for the pharmacotherapy of obesity are very limited. This is not due to lack of interest or research on the subject but rather to the poor efficacy and/or safety profile of the majority of ...

journal_title：Current pharmaceutical design

authors： Gouni-Berthold I,Brüning JC,Berthold HK

更新日期：2013-01-01 00:00:00

abstract：:Colchicine is a lipophilic alkaloid drug, which exhibits ant-inflammatory and anti-fibrotic properties. Cardinal mechanisms of action of colchicine are the disruption of the microtubule system and the inhibition of neutrophil adhesion and recruitment. Colchicine is indicated in the prevention and treatment of gouty ar...

journal_title：Current pharmaceutical design

authors： Marinaki S,Skalioti C,Boletis JN

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:To investigate if low-dose lithium may counteract the microstructural and metabolic brain changes proposed to occur in individuals at ultra-high risk (UHR) for psychosis. METHODS:Hippocampal T2 relaxation time (HT2RT) and proton magnetic resonance spectroscopy ((1)H-MRS) measurements were performed prior to...

journal_title：Current pharmaceutical design

authors： Berger GE,Wood SJ,Ross M,Hamer CA,Wellard RM,Pell G,Phillips L,Nelson B,Amminger GP,Yung AR,Jackson G,Velakoulis D,Pantelis C,Manji H,McGorry PD

更新日期：2012-01-01 00:00:00

abstract：:Since the discovery of human immunodeficiency virus (HIV) as a causative agent of acquired immune deficiency syndrome (AIDS) various strategies were employed to counter its devastating actions. One such concept relies on the prevention of HIV entry into host's "competent" cells by means of compounds known as entry inh...

journal_title：Current pharmaceutical design

authors： Micewicz ED,Ruchala P

更新日期：2013-01-01 00:00:00

abstract：:Dengue is one of the most important arboviral infections worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. He...

journal_title：Current pharmaceutical design

authors： Reginald K,Chan Y,Plebanski M,Poh CL

更新日期：2018-01-01 00:00:00

abstract：:In the last two decades quantitative electroencephalogram (EEG) analysis has been widely used to investigate the neurophysiological characteristics of insomnia. These studies provided evidence in support of the hypothesis that primary insomnia is associated with hyperarousal of central nervous system and altered sleep...

journal_title：Current pharmaceutical design

authors： Marzano C,Ferrara M,Sforza E,De Gennaro L

更新日期：2008-01-01 00:00:00

abstract：:Fetal Alcohol Syndrome (FAS), the most severe manifestation of Fetal Alcohol Spectrum Disorder (FASD) is considered the leading non-hereditary cause of mental retardation and neurological deficit in the Western world. There lie a huge associated human cost to both FASD victims and their families and a considerable fin...

journal_title：Current pharmaceutical design

authors： Brennan D,Giles S

更新日期：2014-01-01 00:00:00

abstract：:Over the past decade, Lymphocyte Function-Associated Antigen-1 (LFA-1, alphaLbeta2, CD11a/CD18) has emerged as an attractive therapeutic target for the treatment of multiple inflammatory diseases. Its established role in the trafficking and activation of leukocytes coupled with the recent elucidation of the global con...

journal_title：Current pharmaceutical design

authors： Giblin PA,Lemieux RM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a frequent female reproductive endocrine disease. It has been associated with a number of severe reproductive and metabolic abnormalities. However, there are still open questions especially regarding the best long-term management. METHODS:We summarized the literature focu...

journal_title：Current pharmaceutical design

authors： Ruan X,Li M,Mueck AO

更新日期：2018-01-01 00:00:00

abstract：:Arterial thromboembolism is a sudden obstruction of arterial blood flow caused by dislodgment of a blood clot from the site of its formation. Atrial fibrillation (AF) is the most common cardiac arrhythmia and a major risk factor for arterial thromboembolism in clinical practice. Most of AF-related arterial thromboembo...

journal_title：Current pharmaceutical design

authors： Potpara TS,Lip GY

更新日期：2010-01-01 00:00:00

abstract：:Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they devel...

journal_title：Current pharmaceutical design

authors： Kolovou G,Anagnostopoulou K,Mikhailidis DP,Cokkinos DV

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Diabetic dyslipidemia has specifics that differ from dyslipidemia in patients without diabetes, which contributes to accelerated atherosclerosis equally as dysglycemia. The aim of this study was to deduce the interdependence of diabetic dyslipidemia and cardiovascular diseases (CVD), therapeutic strategies a...

journal_title：Current pharmaceutical design

authors： Vavlukis M,Kedev S

更新日期：2018-01-01 00:00:00

abstract：:This review summarizes some of the published attempts to incorporate protein and NMR structures in the design of new antibiotics that specifically target Cell Wall biosynthesis. Most of the steps involved in peptidglycan synthesis have been investigated as potential strategies against cell wall inhibition. Structural ...

journal_title：Current pharmaceutical design

authors： Katz AH,Caufield CE

更新日期：2003-01-01 00:00:00

abstract：:Inflammation is part of an important mechanism triggered by the innate immune response that rapidly responds to invading microorganisms and tissue injury. One important elicitor of the inflammatory response is the Gram-negative bacteria component lipopolysaccharide (LPS), which induces the activation of innate immune ...

journal_title：Current pharmaceutical design

authors： de Almeida OP Jr,Toledo TR,Rossi D,Rossetto Dde B,Watanabe TF,Galvão FC,Medeiros AI,Zanelli CF,Valentini SR

更新日期：2014-01-01 00:00:00

abstract：:Cumulative scientific evidence gathered over the past ten years has confirmed the role of platelet GP IIb/IIIa inhibitors in reducing ischemic complications of patients undergoing percutaneous coronary intervention (PCI). Recently, mortality data available on more than 20,000 patients enrolled in randomized clinical t...

journal_title：Current pharmaceutical design

authors： Dery JP,Harrington RA,Tcheng JE

更新日期：2004-01-01 00:00:00

abstract：:Nucleoside reverse transcriptase inhibitors (NRTIs) are components of most current antiretroviral (ARV) regimens. Side effects arising from mitochondrial toxicity (MtT) induced by these drugs is a common reason why patients treated with NRTI change or discontinue therapy. These toxicities can be difficult to reverse, ...

journal_title：Current pharmaceutical design

authors： Feeney ER,Mallon PW

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Bevacizumab (BVZ) is a recombinant humanized antibody that inhibits the vascular endothelial growth factor A (VEGFA) and is used for the treatment of various types of cancer. BVZ is primarily given by the intravenous drip (I.V.), which often leads to low efficacy and various side effects. There...

journal_title：Current pharmaceutical design

authors： Jiang X,Zhang QL,Liu TG,Zhao WP,Yang M,Wang LN,Sun WL,Pan L,Luo AP,Huang JC,Gu XH

更新日期：2019-01-01 00:00:00