Abstract：
:Thin films of amorphous carbon and amorphous, graphitic and fullerene-like carbon nitride were deposited by reactive magnetron sputtering and optically characterized with spectroscopic ellipsometry. Complementary studies using scanning electron microscopy and atomic force microscopy were performed. The films were exposed to human serum albumin (HSA) and the adsorption was monitored in situ using dynamic ellipsometry. From the ellipsometric data the adsorbed amount of proteins was quantified in terms of surface mass density using de Feijter's model. The results indicate larger adsorption of proteins onto the amorphous films compared to the films with a more textured structure. Complementary studies with 125I-labeled HSA showed an apparent protein adsorption up to six times larger compared to the ellipsometry measurement. In addition, the four types of films were incubated in blood plasma followed by exposure to anti-fibrinogen, anti-HMWK or anti-C3c, revealing the materials' response to complement and contact activation. The amorphous and graphitic carbon nitride exhibit rather high immune activity compared to a titanium reference, whereas the amorphous carbon and the fullerene-like CNx show less immune complement deposition. Compared to the reference, all films exhibit indications of a stronger ability to initiate the intrinsic pathway of coagulation. Finally, the surfaces' bone-bonding ability was investigated by examination of their ability to form calcium phosphate crystals in a simulated body fluid, with a-CNx depositing most calcium phosphate after 21 days of incubation.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Berlind T,Tengvall P,Hultman L,Arwin Hdoi
10.1016/j.actbio.2010.10.024subject
Has Abstractpub_date
2011-03-01 00:00:00pages
1369-78issue
3eissn
1742-7061issn
1878-7568pii
S1742-7061(10)00499-Xjournal_volume
7pub_type
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更新日期：2013-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-07-15 00:00:00
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pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2012-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.actbio.2008.02.025
更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
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更新日期：2011-07-01 00:00:00
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更新日期：2015-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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更新日期：2018-04-15 00:00:00
