Development of biodegradable Mg-Ca alloy sheets with enhanced strength and corrosion properties through the refinement and uniform dispersion of the Mg₂Ca phase by high-ratio differential speed rolling.

abstract：:Pressure ulcers are a significant healthcare concern, especially for elderly populations. Our work served to ameliorate the chronicity of these ulcers by addressing ischemia-reperfusion injury mediated by neutrophils and the concomitant loss of vasculature in these wounds. To this end, chitosan scaffolds loaded with b...

journal_title：Acta biomaterialia

authors： Park CJ,Clark SG,Lichtensteiger CA,Jamison RD,Johnson AJ

更新日期：2009-07-01 00:00:00

abstract：:The application of biodegradable magnesium-based materials in the biomedical field is highly restricted by their low fatigue strength and high corrosion rate in biological environments. Herein, we treated the surface of a biocompatible magnesium alloy AZ31 by severe shot peening in order to evaluate the potential of s...

journal_title：Acta biomaterialia

authors： Bagherifard S,Hickey DJ,Fintová S,Pastorek F,Fernandez-Pariente I,Bandini M,Webster TJ,Guagliano M

更新日期：2018-01-15 00:00:00

abstract：:Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) have been shown to generate bone in vivo by executing an endochondral programme. This may hinder the use of MSCs for articular cartilage regeneration, but opens the possibility of using engineered cartilaginous tissues for large bone defect repair. H...

journal_title：Acta biomaterialia

authors： Sheehy EJ,Mesallati T,Vinardell T,Kelly DJ

更新日期：2015-02-01 00:00:00

abstract：:The study of 316L-type stainless steel reveals a significant anisotropy of nickel release that is dependent on the orientation of the test surface with respect to the casting and rolling direction. Cross-sectional specimens (transversal cuts with respect to the rolling direction) show a substantially higher sensitivit...

journal_title：Acta biomaterialia

authors： Reclaru L,Lüthy H,Ziegenhagen R,Eschler PY,Blatter A

更新日期：2008-05-01 00:00:00

abstract：:Vascular grafts are widely used for a number of medical treatments. Strength, compliance, endothelialization and availability are issues of most concern for vascular graft materials. With current approaches, these requirements are difficult to satisfy simultaneously. To explore an alternative approach, the present stu...

journal_title：Acta biomaterialia

authors： Madhavan K,Belchenko D,Motta A,Tan W

更新日期：2010-04-01 00:00:00

abstract：:Postoperative adhesion is a serious complication that can further lead to morbidity and/or mortality. Polymer anti-adhesion barrier material provides an effective precaution to reduce the probability of postoperative adhesion. Clinical application requires these materials to be easily handled, biocompatible, biodegrad...

journal_title：Acta biomaterialia

authors： Yang Y,Liu X,Li Y,Wang Y,Bao C,Chen Y,Lin Q,Zhu L

更新日期：2017-10-15 00:00:00

abstract：:In the present study, the density functional theory implemented in the Vienna Ab-initio Simulation Package has been used to investigate the alloying effects of different elements of calcium, zinc, yttrium, aluminum and iron when introduced in the Mg crystal lattice. In particular, studies have been conducted to invest...

journal_title：Acta biomaterialia

authors： Velikokhatnyi OI,Kumta PN

更新日期：2010-05-01 00:00:00

abstract：:Scaffolds with a high surface-area-to-volume ratio (SA:V) are advantageous with regard to the attachment and proliferation of cells in the field of tissue engineering. This paper reports on the development of novel melt-spun fibers with a high SA:V, which enhanced the surface effects of a fiber-based scaffold while ma...

journal_title：Acta biomaterialia

authors： Park SJ,Lee BK,Na MH,Kim DS

更新日期：2013-08-01 00:00:00

abstract：:Bioabsorbable polymers are increasingly being used in tissue engineering strategies. Despite the knowledge that some sterilization techniques may affect the physical properties of these polymers, this aspect is often overlooked. We speculate that the type of sterilization method used may influence cellular responses b...

journal_title：Acta biomaterialia

authors： Kroeze RJ,Helder MN,Roos WH,Wuite GJ,Bank RA,Smit TH

更新日期：2010-06-01 00:00:00

abstract：:Dentin contains 1-2μm diameter tubules extending from the pulp cavity to near the junction with enamel. Peritubular dentin (PTD) borders the tubule lumens and is surrounded by intertubular dentin (ITD). Differences in PTD and ITD composition and microstructure remain poorly understood. Here, a (∼200nm)(2), 10.1keV syn...

journal_title：Acta biomaterialia

authors： Stock SR,Deymier-Black AC,Veis A,Telser A,Lux E,Cai Z

更新日期：2014-09-01 00:00:00

abstract：:The boundary layers coating articular cartilage in synovial joints constitute unique biomaterials, providing lubricity at levels unmatched by any human-made materials. The underlying molecular mechanism of this lubricity, essential to joint function, is not well understood. Here we study the interactions between surfa...

journal_title：Acta biomaterialia

authors： Zhu L,Seror J,Day AJ,Kampf N,Klein J

更新日期：2017-09-01 00:00:00

abstract：:Three-dimensional (3-D) cell culture can better mimic physiological conditions in which cells interact with adjacent cells and the extracellular matrix than monolayer culture. We have developed a 3-D cell culture device, the Oxy chip, which can be used to generate and supply oxygen to cell spheroids to prevent hypoxia...

journal_title：Acta biomaterialia

authors： Sato T,Anada T,Hamai R,Shiwaku Y,Tsuchiya K,Sakai S,Baba K,Sasaki K,Suzuki O

更新日期：2019-04-01 00:00:00

abstract：:Critical failures associated with current engineered bone grafts involve insufficient induction of osteogenesis of the implanted cells and lack of vascular integration between graft scaffold and host tissue. This study investigated the combined effects of surface microtextures and biochemical supplements to achieve os...

journal_title：Acta biomaterialia

authors： Song S,Kim EJ,Bahney CS,Miclau T,Marcucio R,Roy S

更新日期：2015-05-01 00:00:00

abstract：:Diabetics are prone to chronic wounds that have slower healing, and methods of accelerating the wound closure and to ensure protection from infections are critically needed. MicroRNA-146a gets dysregulated in diabetic wounds and injection of this microRNA combined with reactive oxygen species-scavenging cerium oxide n...

journal_title：Acta biomaterialia

authors： Sener G,Hilton SA,Osmond MJ,Zgheib C,Newsom JP,Dewberry L,Singh S,Sakthivel TS,Seal S,Liechty KW,Krebs MD

更新日期：2020-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are currently receiving interest as an alternative to conventional antibiotics to treat biomaterial-associated infection. However, the inherent instability of such peptides often limits their efficacy in intended clinical applications. Covalent immobilization of AMPs to surfaces is one st...

journal_title：Acta biomaterialia

authors： Atefyekta S,Pihl M,Lindsay C,Heilshorn SC,Andersson M

更新日期：2019-01-01 00:00:00

abstract：:This study deals with cytotoxicity assays performed on an array of commercially manufactured inorganic nanoparticulate materials, including Ag, TiO(2), Fe(2)O(3), Al(2)O(3), ZrO(2), Si(3)N(4), naturally occurring mineral chrysotile asbestos and carbonaceous nanoparticulate materials such as multiwall carbon nanotube a...

journal_title：Acta biomaterialia

authors： Soto K,Garza KM,Murr LE

更新日期：2007-05-01 00:00:00

abstract：:Gene therapies have great potential in regenerative medicine; however, clinical translation has been inhibited by low stability and limited transfection efficiencies. Herein, we incorporate collagen-mimetic peptide (CMP)-linked polyplexes in collagen scaffolds to increase DNA stability by up to 400% and enable tailora...

journal_title：Acta biomaterialia

authors： Urello MA,Kiick KL,Sullivan MO

更新日期：2017-10-15 00:00:00

abstract：:Aortic aneurysm is a leading cause of death in adults, often taking lives without any premonitory signs or symptoms. Adverse clinical outcomes of aortic aneurysm are preventable by elective surgical repair; however, identifying at-risk individuals is difficult. The objective of this study was to perform a predictive b...

journal_title：Acta biomaterialia

authors： Martin C,Sun W,Pham T,Elefteriades J

更新日期：2013-12-01 00:00:00

abstract：:In the present report, a degradable gene delivery system (PAMS/DNA/10NLS) containing nucleus location signal peptide (NLS) was prepared. The agarose gel electrophoresis, particle size and zeta potential of PAMS/DNA/10NLS were similar to those of PAMS/DNA, which proved that NLS did not affect the interaction between PA...

journal_title：Acta biomaterialia

authors： Chen K,Guo L,Zhang J,Chen Q,Wang K,Li C,Li W,Qiao M,Zhao X,Hu H,Chen D

更新日期：2017-01-15 00:00:00

abstract：:Cellular transplantation is now closer to becoming a practical clinical strategy to repair, regenerate or restore the function of skin, muscle, nerves and pancreatic islets. In this study we sought to develop a simple injectable collagen matrix that would preserve the normal cellular organization of skin cells. Three ...

journal_title：Acta biomaterialia

authors： Hartwell R,Leung V,Chavez-Munoz C,Nabai L,Yang H,Ko F,Ghahary A

更新日期：2011-08-01 00:00:00

abstract：:The quest for predictive tumor markers for osteosarcoma (OS) has not well progressed over the last two decades due to a lack of preclinical models. The aim of this study was to investigate if microenvironmental modifications in an original humanized in vivo model alter the expression of OS tumor markers. Human bone mi...

journal_title：Acta biomaterialia

authors： Wagner F,Holzapfel BM,Martine LC,McGovern J,Lahr CA,Boxberg M,Prodinger PM,Grässel S,Loessner D,Hutmacher DW

更新日期：2019-04-15 00:00:00

abstract：:Antibiotic resistance is a major challenge to the treatment of bacterial infections associated with medical devices and biomaterials. One important intrinsic mechanism of such resistance is the formation of persister cells that are phenotypic variants of microorganisms and highly tolerant to antibiotics. Recently, we ...

journal_title：Acta biomaterialia

authors： Niepa THR,Wang H,Gilbert JL,Ren D

更新日期：2017-03-01 00:00:00

abstract：:Sr and CO3 co-substituted hydroxyapatite (SrCHA) nanopowder was synthesized by neutralization. The powder was characterized. The improved solubility in Hanks' balanced solution of SrCHA granules (400-600 microm of dimensional range), potentially usable as bone filler, was assessed and compared with that of an analogou...

journal_title：Acta biomaterialia

authors： Landi E,Sprio S,Sandri M,Celotti G,Tampieri A

更新日期：2008-05-01 00:00:00

abstract：UNLABELLED:Recent studies reveal many biomaterial vaccine carriers are able to activate immunostimulatory pathways, even in the absence of other immune signals. How the changing properties of polymers during biodegradation impact this intrinsic immunogenicity is not well studied, yet this information could contribute t...

journal_title：Acta biomaterialia

authors： Andorko JI,Hess KL,Pineault KG,Jewell CM

更新日期：2016-03-01 00:00:00

abstract：:Total joint replacement is a widely used and successful surgical approach. Approximately 7 million US adults are currently living with a hip or knee replacement. However, the surgical procedures for total joint replacement are associated with significant postoperative pain, and current strategies do not adequately add...

journal_title：Acta biomaterialia

authors： Grindy SC,Gil D,Suhardi JV,Muratoglu OK,Bedair H,Oral E

更新日期：2019-07-15 00:00:00

abstract：:Photochemical internalisation (PCI) is a method for enhancing delivery of drugs to their intracellular target sites of action. In this study we investigated the efficacy of PCI using a porphyrin photosensitiser and a cytotoxic agent on spheroid and non-spheroid compressed collagen 3D constructs of ovarian cancer versu...

journal_title：Acta biomaterialia

authors： Hadi LM,Yaghini E,Stamati K,Loizidou M,MacRobert AJ

更新日期：2018-11-01 00:00:00

abstract：:The calcareous spicules from sponges, e.g. from Sycon raphanus, are composed of almost pure calcium carbonate. In order to elucidate the formation of those structural skeletal elements, the function of the enzyme carbonic anhydrase (CA), isolated from this species, during the in vitro calcium carbonate-based spicule f...

journal_title：Acta biomaterialia

authors： Müller WE,Schlossmacher U,Schröder HC,Lieberwirth I,Glasser G,Korzhev M,Neufurth M,Wang X

更新日期：2014-01-01 00:00:00

abstract：:Creating micro/nanostructured hydrogels with tunable morphologies under cell-friendly processing conditions would enable rational engineering of hydrogel scaffolds for targeted biomedical applications. Herein, an all-aqueous single-step reactive electrospinning method is applied to prepare hydrogel networks with contr...

journal_title：Acta biomaterialia

authors： Xu F,Gough I,Dorogin J,Sheardown H,Hoare T

更新日期：2020-03-01 00:00:00

abstract：:Nanocrystalline hydroxyapatite (HAp) and silicon-containing hydroxyapatite (SiHAp) particles were synthesized by a wet-chemical procedure and their heterogeneous structures involving a disordered phase were analyzed in detail by X-ray diffractometry (XRD), transmission electron microscopy (TEM), Fourier transform infr...

journal_title：Acta biomaterialia

authors： Hayakawa S,Kanaya T,Tsuru K,Shirosaki Y,Osaka A,Fujii E,Kawabata K,Gasqueres G,Bonhomme C,Babonneau F,Jäger C,Kleebe HJ

更新日期：2013-01-01 00:00:00

abstract：:Porcupines use their lightweight quills, which are strong enough to support significant compression and flexure loads, for defense. Hystrix, with long and thick quills, belongs to the family of Hystricidae (Old World porcupines), while Erethizon, with smaller quills, belongs to the Erethizontidae family (New World por...

journal_title：Acta biomaterialia

authors： Yang W,Chao C,McKittrick J

更新日期：2013-02-01 00:00:00