Abstract:
:Pseudogenes are defined as nonfunctional DNA sequences with homology to functional protein-coding genes, and they typically contain nonfunctional mutations within the presumptive coding region. In theory, pseudogenes can also be caused by mutations in upstream regulatory regions, appearing as open reading frames with attenuated expression. In this study, we identified 1,939 annotated protein-coding genes with little evidence of expression in Arabidopsis thaliana and characterized their molecular evolutionary characteristics. On average, this set of genes was shorter than expressed genes and evolved with a 2-fold higher rate of nonsynonymous substitutions. The divergence of upstream sequences, based on ortholog comparisons to A. lyrata, was also higher than expressed genes, suggesting that these lowly expressed genes could be examples of pseudogenization by promoter disablement, often due to transposable element insertion. We complemented our empirical study by extending the models of Force et al. (Force A, Lynch M, Pickett FB, Amores A, Yan YL, Postlethwait J. 1999. Preservation of duplicate genes by complementary, degenerative mutations. Genetics 151:1531-1545.) to derive the probability of promoter disablements after gene duplication.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Yang L,Takuno S,Waters ER,Gaut BSdoi
10.1093/molbev/msq298subject
Has Abstractpub_date
2011-03-01 00:00:00pages
1193-203issue
3eissn
0737-4038issn
1537-1719pii
msq298journal_volume
28pub_type
杂志文章abstract::The level of DNA polymorphism in the ancestral species at the time of speciation can be estimated using DNA sequences from many loci sampled from 2 or more extant species. The comparison between ancestral and extant polymorphism can be informative about the population genetics of speciation. In this study, we collecte...
journal_title:Molecular biology and evolution
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更新日期:2006-05-01 00:00:00
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pub_type: 评论,杂志文章
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更新日期:1996-03-01 00:00:00
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更新日期:2005-02-01 00:00:00
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更新日期:2013-02-01 00:00:00
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更新日期:2021-01-23 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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