当前位置： SCI文献检索 > Science Translational Medicine期刊下所有文献 > Femtosecond laser-assisted cataract surgery with integrated optical coherence tomography.

Femtosecond laser-assisted cataract surgery with integrated optical coherence tomography.

Abstract：

:About one-third of people in the developed world will undergo cataract surgery in their lifetime. Although marked improvements in surgical technique have occurred since the development of the current approach to lens replacement in the late 1960s and early 1970s, some critical steps of the procedure can still only be executed with limited precision. Current practice requires manual formation of an opening in the anterior lens capsule, fragmentation and evacuation of the lens tissue with an ultrasound probe, and implantation of a plastic intraocular lens into the remaining capsular bag. The size, shape, and position of the anterior capsular opening (one of the most critical steps in the procedure) are controlled by freehand pulling and tearing of the capsular tissue. Here, we report a technique that improves the precision and reproducibility of cataract surgery by performing anterior capsulotomy, lens segmentation, and corneal incisions with a femtosecond laser. The placement of the cuts was determined by imaging the anterior segment of the eye with integrated optical coherence tomography. Femtosecond laser produced continuous anterior capsular incisions, which were twice as strong and more than five times as precise in size and shape than manual capsulorhexis. Lens segmentation and softening simplified its emulsification and removal, decreasing the perceived cataract hardness by two grades. Three-dimensional cutting of the cornea guided by diagnostic imaging creates multiplanar self-sealing incisions and allows exact placement of the limbal relaxing incisions, potentially increasing the safety and performance of cataract surgery.

journal_name

Sci Transl Med

journal_title

Science translational medicine

authors

Palanker DV,Blumenkranz MS,Andersen D,Wiltberger M,Marcellino G,Gooding P,Angeley D,Schuele G,Woodley B,Simoneau M,Friedman NJ,Seibel B,Batlle J,Feliz R,Talamo J,Culbertson W

doi

10.1126/scitranslmed.3001305

subject

Has Abstract

pub_date

2010-11-17 00:00:00

pages

58ra85

issue

58

eissn

1946-6234

issn

1946-6242

pii

2/58/58ra85

journal_volume

2

pub_type

临床试验,杂志文章

相关文献

Science Translational Medicine文献大全
  • Temporal dynamics of the human vaginal microbiota.

    abstract：:Elucidating the factors that impinge on the stability of bacterial communities in the vagina may help in predicting the risk of diseases that affect women's health. Here, we describe the temporal dynamics of the composition of vaginal bacterial communities in 32 reproductive-age women over a 16-week period. The analys...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3003605

    authors： Gajer P,Brotman RM,Bai G,Sakamoto J,Schütte UM,Zhong X,Koenig SS,Fu L,Ma ZS,Zhou X,Abdo Z,Forney LJ,Ravel J

    更新日期：2012-05-02 00:00:00

  • Exosomes derived from Vδ2-T cells control Epstein-Barr virus-associated tumors and induce T cell antitumor immunity.

    abstract：:Treatment of life-threatening Epstein-Barr virus (EBV)-associated tumors remains a great challenge, especially for patients with relapsed or refractory disease. Here, we found that exosomes derived from phosphoantigen-expanded Vδ2-T cells (Vδ2-T-Exos) contained death-inducing ligands (FasL and TRAIL), an activating re...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaz3426

    authors： Wang X,Xiang Z,Liu Y,Huang C,Pei Y,Wang X,Zhi H,Wong WH,Wei H,Ng IO,Lee PP,Chan GC,Lau YL,Tu W

    更新日期：2020-09-30 00:00:00

  • Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing.

    abstract：:In humans, exposure to aristolochic acid (AA) is associated with urothelial carcinoma of the upper urinary tract (UTUC). Exome sequencing of UTUCs from 19 individuals with documented exposure to AA revealed a remarkably large number of somatic mutations and an unusual mutational signature attributable to AA. Most of t...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3006200

    authors： Hoang ML,Chen CH,Sidorenko VS,He J,Dickman KG,Yun BH,Moriya M,Niknafs N,Douville C,Karchin R,Turesky RJ,Pu YS,Vogelstein B,Papadopoulos N,Grollman AP,Kinzler KW,Rosenquist TA

    更新日期：2013-08-07 00:00:00

  • Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.

    abstract：:Arrhythmogenic cardiomyopathy (ACM) is characterized by frequent cardiac arrhythmias. To elucidate the underlying mechanisms and discover potential chemical modifiers, we created a zebrafish model of ACM with cardiac myocyte-specific expression of the human 2057del2 mutation in the gene encoding plakoglobin. A high-th...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3008008

    authors： Asimaki A,Kapoor S,Plovie E,Karin Arndt A,Adams E,Liu Z,James CA,Judge DP,Calkins H,Churko J,Wu JC,MacRae CA,Kléber AG,Saffitz JE

    更新日期：2014-06-11 00:00:00

  • Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.

    abstract：:Chemotherapy-induced cardiotoxicity (CIC) is a common clinical problem that compromises effective anticancer therapies. Many chemotherapeutics (including anthracyclines, such as doxorubicin) induce the proapoptotic transcription factor p53 in the tumor and nonspecifically in the heart, promoting heart failure. Althoug...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aau8866

    authors： Saleme B,Gurtu V,Zhang Y,Kinnaird A,Boukouris AE,Gopal K,Ussher JR,Sutendra G

    更新日期：2019-02-06 00:00:00

  • Grease fires turn up the heat in autoimmune disease.

    abstract：:Restoring reverse cholesterol transport ameliorates the B cell hyperexpansion and autoimmune disease found to be associated with accumulation of cholesterol in CD11c+ antigen-presenting cells. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aal4997

    authors： Bhakta NR

    更新日期：2017-01-25 00:00:00

  • Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers.

    abstract：:Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations in the presenilin (PSEN) gene have been postulated to result from increased production of Aβ42 compared to Aβ40 in the central nervous system (CNS)...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3005615

    authors： Potter R,Patterson BW,Elbert DL,Ovod V,Kasten T,Sigurdson W,Mawuenyega K,Blazey T,Goate A,Chott R,Yarasheski KE,Holtzman DM,Morris JC,Benzinger TL,Bateman RJ

    更新日期：2013-06-12 00:00:00

  • A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.

    abstract：:Buprenorphine, a synthetic opioid that acts at both μ and κ opioid receptors, can decrease cocaine use in individuals with opioid addiction. However, the potent agonist action of buprenorphine at μ opioid receptors raises its potential for creating opioid dependence in non-opioid-dependent cocaine abusers. Here, we te...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3003948

    authors： Wee S,Vendruscolo LF,Misra KK,Schlosburg JE,Koob GF

    更新日期：2012-08-08 00:00:00

  • Wireless sensors for continuous, multimodal measurements at the skin interface with lower limb prostheses.

    abstract：:Precise form-fitting of prosthetic sockets is important for the comfort and well-being of persons with limb amputations. Capabilities for continuous monitoring of pressure and temperature at the skin-prosthesis interface can be valuable in the fitting process and in monitoring for the development of dangerous regions ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.abc4327

    authors： Kwak JW,Han M,Xie Z,Chung HU,Lee JY,Avila R,Yohay J,Chen X,Liang C,Patel M,Jung I,Kim J,Namkoong M,Kwon K,Guo X,Ogle C,Grande D,Ryu D,Kim DH,Madhvapathy S,Liu C,Yang DS,Park Y,Caldwell R,Banks A,Xu S,H

    更新日期：2020-12-16 00:00:00

  • A molecular bandage for diseased muscle.

    abstract：:MG53 promotes sarcolemmal repair in the mdx mouse model of Duchenne muscular dystrophy (Weisleder et al., this issue) and identifies a new protein therapeutic for muscle disease. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.3004082

    authors： Burkin DJ,Wuebbles RD

    更新日期：2012-06-20 00:00:00

  • Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.

    abstract：:Meibomian glands (MGs) are sebaceous glands of the eyelid margin that secrete lipids needed to avert tear evaporation and to help maintain ocular surface homeostasis. Obstruction of MGs or other forms of MG dysfunction can promote chronic diseases of the ocular surface. Although chronic eyelid inflammation, such as al...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aas9164

    authors： Reyes NJ,Yu C,Mathew R,Kunnen CM,Kalnitsky J,Redfern RL,Leonardi A,Perez VL,MacLeod AS,Gupta PK,Saban DR

    更新日期：2018-07-25 00:00:00

  • Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies.

    abstract：:Essential hypertension is a complex, multifactorial disease associated with a high cardiovascular risk and whose genetic-molecular basis is heterogeneous and largely unknown. Although multiple antihypertensive therapies are available, the large individual variability in drug response results in only a modest reduction...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3001815

    authors： Ferrandi M,Molinari I,Torielli L,Padoani G,Salardi S,Rastaldi MP,Ferrari P,Bianchi G

    更新日期：2010-11-24 00:00:00

  • Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States.

    abstract：:Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections to date has relied heavily on reverse transcription polymerase chain reaction testing. However, limited test availability, high false-negative rates, and the existence of asymptomatic or subclinical infections have resulted in an unde...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.abc1126

    authors： Silverman JD,Hupert N,Washburne AD

    更新日期：2020-07-29 00:00:00

  • Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.

    abstract：:The amyloid-forming proteins tau, αB crystallin, and amyloid P protein are all found in lesions of multiple sclerosis (MS). Our previous work established that amyloidogenic peptides from the small heat shock protein αB crystallin (HspB5) and from amyloid β fibrils, characteristic of Alzheimer's disease, were therapeut...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3005681

    authors： Kurnellas MP,Adams CM,Sobel RA,Steinman L,Rothbard JB

    更新日期：2013-04-03 00:00:00

  • Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models.

    abstract：:Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes to many potentially lethal pathologies including myocardial infarction, stroke, and cancer. We hypothesized that modified platelets lacking their aggregation and activation capacity could act as reversible inhibitors of platel...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aau5898

    authors： Papa AL,Jiang A,Korin N,Chen MB,Langan ET,Waterhouse A,Nash E,Caroff J,Graveline A,Vernet A,Mammoto A,Mammoto T,Jain A,Kamm RD,Gounis MJ,Ingber DE

    更新日期：2019-02-13 00:00:00

  • Striatal dopamine regulates systemic glucose metabolism in humans and mice.

    abstract：:The brain is emerging as an important regulator of systemic glucose metabolism. Accumulating data from animal and observational human studies suggest that striatal dopamine signaling plays a role in glucose regulation, but direct evidence in humans is currently lacking. We present a series of experiments supporting th...

    journal_title：Science translational medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1126/scitranslmed.aar3752

    authors： Ter Horst KW,Lammers NM,Trinko R,Opland DM,Figee M,Ackermans MT,Booij J,van den Munckhof P,Schuurman PR,Fliers E,Denys D,DiLeone RJ,la Fleur SE,Serlie MJ

    更新日期：2018-05-23 00:00:00

  • Research results: preserving newborn blood samples.

    abstract：:Retention and use, without explicit parental permission, of residual dried blood samples from newborn screening has generated public controversy over concerns about violations of family privacy rights and loss of parental autonomy. The public debate about this issue has included little discussion a...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3004474

    authors： Lewis MH,Scheurer ME,Green RC,McGuire AL

    更新日期：2012-11-07 00:00:00

  • The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.

    abstract：:Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. The most common CF-associated mutation is ΔF508, which deletes a phenylalanine in position 508. In vitro studies indicate that the resultant prot...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3001868

    authors： Ostedgaard LS,Meyerholz DK,Chen JH,Pezzulo AA,Karp PH,Rokhlina T,Ernst SE,Hanfland RA,Reznikov LR,Ludwig PS,Rogan MP,Davis GJ,Dohrn CL,Wohlford-Lenane C,Taft PJ,Rector MV,Hornick E,Nassar BS,Samuel M,Zhang Y,Richt

    更新日期：2011-03-16 00:00:00

  • Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits.

    abstract：:Accumulating evidence has shown that repeated exposure to general anesthesia during critical stages of brain development results in long-lasting behavioral deficits later in life. To date, there has been no effective treatment to mitigate the neurotoxic effects of anesthesia on brain development. By performing calcium...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaf7151

    authors： Huang L,Cichon J,Ninan I,Yang G

    更新日期：2016-06-22 00:00:00

  • Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure.

    abstract：:Despite the existence of effective rabies vaccines for dogs, dog-transmitted human rabies persists and has reemerged in Africa. Two consecutive dog vaccination campaigns took place in Chad in 2012 and 2013 (coverage of 71% in both years) in the capital city of N'Djaména, as previously published. We developed a determi...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaf6984

    authors： Zinsstag J,Lechenne M,Laager M,Mindekem R,Naïssengar S,Oussiguéré A,Bidjeh K,Rives G,Tessier J,Madjaninan S,Ouagal M,Moto DD,Alfaroukh IO,Muthiani Y,Traoré A,Hattendorf J,Lepelletier A,Kergoat L,Bourhy H,Dacheux L,

    更新日期：2017-12-20 00:00:00

  • Imaging approaches to optimize molecular therapies.

    abstract：:Imaging, including its use for innovative tissue sampling, is slowly being recognized as playing a pivotal role in drug development, clinical trial design, and more effective delivery and monitoring of molecular therapies. The challenge is that, while a considerable number of new imaging technologies and new targeted ...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.aaf3936

    authors： Weissleder R,Schwaiger MC,Gambhir SS,Hricak H

    更新日期：2016-09-07 00:00:00

  • PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) of the skin are autoimmune diseases characterized by inappropriate immune responses against self-proteins; the key elements that determine disease pathogenesis and progression are largely unknown. Here, we show that mice lacking immune inhibitory...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aax1159

    authors： Han X,Vesely MD,Yang W,Sanmamed MF,Badri T,Alawa J,López-Giráldez F,Gaule P,Lee SW,Zhang JP,Nie X,Nassar A,Boto A,Flies DB,Zheng L,Kim TK,Moeckel GW,McNiff JM,Chen L

    更新日期：2019-12-11 00:00:00

  • Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration.

    abstract：:Age is the most significant risk factor for atherosclerosis; however, the link between age and atherosclerosis is poorly understood. During both aging and atherosclerosis progression, the blood vessel wall stiffens owing to alterations in the extracellular matrix. Using in vitro and ex vivo models of vessel wall stiff...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3002761

    authors： Huynh J,Nishimura N,Rana K,Peloquin JM,Califano JP,Montague CR,King MR,Schaffer CB,Reinhart-King CA

    更新日期：2011-12-07 00:00:00

  • Systemic AAV9.LAMP2B injection reverses metabolic and physiologic multiorgan dysfunction in a murine model of Danon disease.

    abstract：:Danon disease (DD) is a rare X-linked autophagic vacuolar myopathy associated with multiorgan dysfunction, including the heart, skeletal muscle, and liver. There are no specific treatments, and most male patients die from advanced heart failure during the second or third decade of life. DD is caused by mutations in th...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aax1744

    authors： Manso AM,Hashem SI,Nelson BC,Gault E,Soto-Hermida A,Villarruel E,Brambatti M,Bogomolovas J,Bushway PJ,Chen C,Battiprolu P,Keravala A,Schwartz JD,Shah G,Gu Y,Dalton ND,Hammond K,Peterson K,Saftig P,Adler ED

    更新日期：2020-03-18 00:00:00

  • Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration.

    abstract：:Rapid advancements in the field of stem cell biology have led to many current efforts to exploit stem cells as therapeutic agents in regenerative medicine. However, current ex vivo cell manipulations common to most regenerative approaches create a variety of technical and regulatory hurdles to their clinical translati...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3008234

    authors： Arany PR,Cho A,Hunt TD,Sidhu G,Shin K,Hahm E,Huang GX,Weaver J,Chen AC,Padwa BL,Hamblin MR,Barcellos-Hoff MH,Kulkarni AB,J Mooney D

    更新日期：2014-05-28 00:00:00

  • Sponsors meet scientists to speed pediatric medicines development.

    abstract：:The Point-Person Project, a child-health research initiative, enables rapid response to opportunities for participation in multicenter pediatric clinical trials. ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaa2045

    authors： Davis JM,Smoyer WE,Connor EM,Huskins WC,Pastern C,Purucker M,Schrader EC,Jackson CR,Kaskel FJ,Hirschfeld S

    更新日期：2015-03-18 00:00:00

  • Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: results from a pilot clinical study.

    abstract：:Targeting androgen receptor (AR) axis signaling by disrupting androgen-AR interactions remains the primary treatment for metastatic prostate cancer. Unfortunately, all men develop resistance to primary castrating therapy and secondary androgen deprivation therapies (ADTs). Resistance develops in part because castratio...

    journal_title：Science translational medicine

    pub_type： 临床试验,杂志文章

    doi：10.1126/scitranslmed.3010563

    authors： Schweizer MT,Antonarakis ES,Wang H,Ajiboye AS,Spitz A,Cao H,Luo J,Haffner MC,Yegnasubramanian S,Carducci MA,Eisenberger MA,Isaacs JT,Denmeade SR

    更新日期：2015-01-07 00:00:00

  • Epidermal electronics for noninvasive, wireless, quantitative assessment of ventricular shunt function in patients with hydrocephalus.

    abstract：:Hydrocephalus is a common and costly neurological condition caused by the overproduction and/or impaired resorption of cerebrospinal fluid (CSF). The current standard of care, ventricular catheters (shunts), is prone to failure, which can result in nonspecific symptoms such as headaches, dizziness, and nausea. Current...

    journal_title：Science translational medicine

    pub_type： 临床试验,杂志文章

    doi：10.1126/scitranslmed.aat8437

    authors： Krishnan SR,Ray TR,Ayer AB,Ma Y,Gutruf P,Lee K,Lee JY,Wei C,Feng X,Ng B,Abecassis ZA,Murthy N,Stankiewicz I,Freudman J,Stillman J,Kim N,Young G,Goudeseune C,Ciraldo J,Tate M,Huang Y,Potts M,Rogers JA

    更新日期：2018-10-31 00:00:00

  • One integrin to rule them all?

    abstract：:Myofibroblast-derived αvβ1 integrin has emerged as a critical mediator of transforming growth factor-β activation in experimental models of tissue fibrosis (Reed et al., this issue). ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aab0044

    authors： Dietz HC

    更新日期：2015-05-20 00:00:00

  • Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production.

    abstract：:Elevated serum levels of both total and allergen-specific immunoglobulin E (IgE) correlate with atopic diseases such as allergic rhinitis and allergic asthma. Neutralization of IgE by anti-IgE antibodies can effectively treat allergic asthma. Preclinical studies indicate that targeting membrane IgE-positive cells with...

    journal_title：Science translational medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1126/scitranslmed.3008961

    authors： Gauvreau GM,Harris JM,Boulet LP,Scheerens H,Fitzgerald JM,Putnam WS,Cockcroft DW,Davis BE,Leigh R,Zheng Y,Dahlén B,Wang Y,Maciuca R,Mayers I,Liao XC,Wu LC,Matthews JG,O'Byrne PM

    更新日期：2014-07-02 00:00:00