Selenium and vitamin E treatment of Duchenne muscular dystrophy: no effect on muscle function.

Abstract:

:16 boys with Duchenne muscular dystrophy (DMD) were treated with sodium selenite and vitamin E for one year. One group of patients (10 boys) was examined using a battery of tests to assess muscular strength and function and cardiopulmonary function, and by CT scanning of 2 muscle groups over the 4 years prior to treatment. Six boys with DMD entered the study when the treatment was begun. Tests of muscular force and function, cardiopulmonary tests and CT-scanning were performed at the onset of treatment, and after 6 and 12 months. No beneficial effect on either muscular force or function was found during the treatment period. It is concluded that selenium and vitamin E in high doses do not improve muscle function in DMD.

journal_name

Acta Neurol Scand

authors

Bäckman E,Nylander E,Johansson I,Henriksson KG,Tagesson C

doi

10.1111/j.1600-0404.1988.tb03681.x

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

429-35

issue

5

eissn

0001-6314

issn

1600-0404

journal_volume

78

pub_type

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