当前位置： SCI文献检索 > MARINE POLLUTION BULLETIN期刊下所有文献 > Effects of the pharmaceuticals gemfibrozil and diclofenac on the marine mussel (Mytilus spp.) and their comparison with standardized toxicity tests.

Effects of the pharmaceuticals gemfibrozil and diclofenac on the marine mussel (Mytilus spp.) and their comparison with standardized toxicity tests.

Abstract：

:Human pharmaceuticals, like the lipid lowering agent gemfibrozil and the non-steroidal anti-inflammatory drug diclofenac are causing environmental concern. In this study, the marine mussel (Mytilus spp.) was exposed by injection to environmentally relevant and elevated (1 μg/L and 1000 μg/L) concentrations of both compounds and biomarker expression was observed. Gemfibrozil exposure induced biomarkers of stress (glutathione S-transferase and metallothionein) at both concentrations 24h and 96 h after exposure, respectively. Biomarkers of damage (lipid peroxidation (LPO) and DNA damage) were significantly affected, as well as the biomarker for reproduction, alkali-labile phosphate assay, indicating the potential oxidative stress and endocrine disrupting effect of gemfibrozil. Diclofenac significantly induced LPO after 96 h indicating tissue damage. Additionally standard toxicity tests using the marine species Vibrio fischeri, Skeletonema costatum and Tisbe battagliai showed differences in sensitivity to both drugs in the mg/L range. Results indicate a suite of tests should be used to give accurate information for regulation.

journal_name

Mar Pollut Bull

journal_title

Marine pollution bulletin

authors

Schmidt W,O'Rourke K,Hernan R,Quinn B

doi

10.1016/j.marpolbul.2011.04.043

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

1389-95

issue

7

eissn

0025-326X

issn

1879-3363

pii

S0025-326X(11)00246-3

journal_volume

62

pub_type

杂志文章

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