Abstract:
BACKGROUND:Emerging data suggests PM2.5 (particulate matter with aerodynamic diameter <2.5 μm) may be associated with both earlier declines in episodic memory (EM) and increased depressive symptoms in older adults. Although late-life depressive symptoms are associated with EM, no longitudinal studies have examined the inter-relationship among PM2.5, depressive symptoms and EM. METHODS:Older women (n = 2,202; aged 67-83 in 1999) enrolled in the Women's Health Initiative Study of Cognitive Aging completed up to eight annual assessments of depressive symptoms (15-item Geriatric Depression Scale) and EM (California Verbal Learning Test). A nationwide spatiotemporal model (1999-2010) was used to estimate ambient PM2.5 exposure at residential locations. Univariate and bivariate structural equation models (SEMs) for latent-change scores were used to examine how 3-year average PM2.5 preceding each assessment affects the temporal dynamics and bidirectional relations of annual changes in depressive symptoms and EM. RESULTS:In univariate SEMs, one inter-quartile (4.04 μg/m3) increment of 3-year PM2.5 was significantly (p < 0.05) associated with accelerated declines in verbal learning (List A trials 1-3: β = -1.48) and free-recall memory (short-delay: β = -1.43; long-delay: β = -1.11), but not with change in depressive symptoms (β = 0.12; p = 0.71). In bivariate SEMs, significant associations were observed between PM2.5 and accelerated declines in EM measures (β = -1.44 to -0.99; p < 0.05) and between EM performance and changes in depressive symptoms (β = -0.08 to -0.05; p < 0.05), with significant indirect PM2.5 effects on changes in depressive symptoms (β = 0.08-0.10; p < 0.05). These findings were robust with adjustment for multiple demographic, lifestyle, and clinical factors, and remained after excluding subjects with dementia or mild cognitive impairment. No associations were found between PM2.5 and change in depressive symptoms or depressive symptoms and subsequent EM decline. CONCLUSIONS:Findings suggest that PM2.5 neurotoxicity may damage brain areas implicated in EM, followed by manifestation of depressive symptoms. Our data did not support depressive symptoms as the neuropsychological mediator of accelerated brain aging associated with PM2.5 exposure.
journal_name
Environ Intjournal_title
Environment internationalauthors
Petkus AJ,Younan D,Widaman K,Gatz M,Manson JE,Wang X,Serre M,Vizuete W,Chui H,Espeland MA,Resnick S,Chen JCdoi
10.1016/j.envint.2019.105196subject
Has Abstractpub_date
2020-02-01 00:00:00pages
105196eissn
0160-4120issn
1873-6750pii
S0160-4120(19)31361-3journal_volume
135pub_type
杂志文章abstract::Dioxin-like compounds (DLCs) are monitored in the U.S. population using data collected with the National Health and Nutrition Examination Survey (NHANES). Until recently, participants' serum samples have been analyzed individually, and summary statistics defining reference ranges by age, gender, and race/ethnicity hav...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.05.003
更新日期:2017-08-01 00:00:00
abstract::A human biomonitoring (HBM) survey in four areas affected by natural or anthropogenic arsenic pollution was conducted in Italy within the framework of the SEpiAs project. A questionnaire, including the exploration of risk perception (RP) regarding environmental hazards and access to and trust in information, was admin...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.07.009
更新日期:2016-10-01 00:00:00
abstract::Studies have shown links between the concentration of allergens found in homes and asthma. Inhalation of allergens present in settled residential dust can occur when the dust is resuspended via human activity or air currents. Although previous studies have measured allergen concentrations in homes, the focus has been ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2009.09.001
更新日期:2010-01-01 00:00:00
abstract::Recent studies show that, even after being banned for agricultural applications for over 30 years, organochlorine pesticides (OCPs), including hexachlorocyclohexanes (HCHs) and dichlorodiphenyltrichloroethane (DDT) and its metabolites (DDXs), can still be found in various biological matrices and pose a potential hazar...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105402
更新日期:2020-02-01 00:00:00
abstract::Organophosphate flame retardants (PFRs) are used as additives in plastics and other applications such as curtains and carpets as a replacement for brominated flame retardants. As such, exposure to PFR mixtures is widespread, with children being more vulnerable than adults to associated health risks such as allergies a...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105003
更新日期:2019-10-01 00:00:00
abstract::Occurrence of flame retardants (FRs) in the indoor environment of highly flame-retarded public facilities is an important concern from the viewpoint of exposure because it is likely that FRs are used to a greater degree in these facilities than in homes. For this study, brominated flame-retardants (BFRs) and organopho...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2008.12.007
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:There is public concern regarding potential health effects of radio frequency electromagnetic fields (RF-EMF) exposure, as produced by mobile phones or broadcast transmitters. The objective of this study was to investigate the association between RF-EMF exposure and non-specific symptoms and tinnitus in a pr...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2011.08.002
更新日期:2012-01-01 00:00:00
abstract::Mercury (Hg) is a potentially harmful trace element in the environment and one of the World Health Organization's foremost chemicals of concern. The threat posed by Hg contaminated soils to humans is pervasive, with an estimated 86 Gg of anthropogenic Hg pollution accumulated in surface soils worldwide. This review cr...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2019.03.019
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Many cities across the world are beginning to shift their mobility solution away from the private cars and towards more environmentally friendly and citizen-focused means. Hamburg, Oslo, Helsinki, and Madrid have recently announced their plans to become (partly) private car free cities. Other cities like Par...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2016.05.032
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Globally, there is increasing scientific evidence of critical links between the oceans and human health, with research into issues such as pollution, harmful algal blooms and nutritional contributions. However, Oceans and Human Health (OHH) remains an emerging discipline. As such these links are poorly recog...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2020.106275
更新日期:2021-01-01 00:00:00
abstract::Serum perfluoroalkyl acids (PFAAs) have been linked to disruption of maternal thyroid hormone homeostasis, but results have varied between studies which we hypothesized was due to timing of the thyroid hormone measurements, variability in PFAA isomer patterns, or presence of other stressors. In a longitudinal study de...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.04.023
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Prenatal and childhood exposure to polybrominated diphenyl ether (PBDE) flame retardants has been inversely associated with cognitive performance, however, few studies have measured PBDE concentrations in samples collected during both prenatal and postnatal periods. METHODS:We examined prenatal (cord) and c...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.05.004
更新日期:2018-09-01 00:00:00
abstract::In China, fine particulate matter (PM2.5) and ground-level ozone (O3) are anticipated to continuously affect large populations in the coming decades. Simulations of the levels of these pollutants largely depend on emissions inputs, which are highly uncertain both in magnitude and spatial distribution. Our goal was to ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.12.002
更新日期:2019-02-01 00:00:00
abstract::The present study used food waste (collected from local hotels and restaurants) feed pellets in polyculture of low-trophic level fish [bighead (Aristichtys nobilis), grass carp (Ctenopharyngodon idellus), and mud carp (Cirrhina molitorella)] aiming at producing safe and quality products for local consumption. The resu...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.07.001
更新日期:2014-12-01 00:00:00
abstract::Substance abuse during pregnancy is an important public health issue affecting the mother and the growing infant. Preterm labor, miscarriage, abruption and postpartum hemorrhage are obstetric complications which have been associated with women who are dependent on abused substances. Moreover, women are also at an incr...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2013.01.011
更新日期:2013-04-01 00:00:00
abstract::Although several studies have reported that social isolation is one of the important health risk factors in the elderly population living in urban areas, its effects on vulnerability to heatwaves have been studied relatively less than climatic and other socio-economic factors. Thus, we investigated the association bet...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105868
更新日期:2020-09-01 00:00:00
abstract::Direct field toxicity tests were performed in two Louisiana waterways, Bayous Trepagnier and St. John, on sediments containing organic/heavy metal mixtures. Our approach involved bioluminescent bacterial toxicity assays (using DeltaTox, which qualitatively identifies polluted areas, and Microtox, which quantifies toxi...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/s0160-4120(01)00105-2
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:It has been suggested that adults who use cleaning agents in their homes have a higher risk of asthma and allergic symptoms. The associations of asthma and allergic symptoms with household use of cleaning agents in adolescents have not been investigated yet. OBJECTIVES:To examine the associations of househo...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.03.049
更新日期:2019-07-01 00:00:00
abstract::Human health burdens associated with long-term exposure to particulate matter (PM) are substantial. The metrics currently recommended by the World Health Organization for quantification of long-term health-relevant PM are the annual average PM10 and PM2.5 mass concentrations, with no low concentration threshold. Howev...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.08.005
更新日期:2016-10-01 00:00:00
abstract::The presence anti-infectives in environmental waters is of interest because of their potential role in the dissemination of anti-infective resistance in bacteria and other harmful effects on non-target species such as algae and shellfish. Since no information on global trends regarding the contamination caused by thes...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2015.04.001
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Exposure to some environmental chemicals is ubiquitous and linked to a variety of adverse outcomes, including children's health. While few studies have assessed the contribution of both male and female exposures to children's health, understanding the patterns of couple's exposure is needed to understand the...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.11.078
更新日期:2019-02-01 00:00:00
abstract::Japanese encephalitis (JE) is the most common cause of viral encephalitis and an important public health concern in the Asia-Pacific region, particularly in China where 50% of global cases are notified. To explore the association between environmental factors and human JE cases and identify the high risk areas for JE ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.07.004
更新日期:2014-12-01 00:00:00
abstract::Mercury contamination in soil, water and air is associated with potential toxicity to humans and ecosystems. Industrial activities such as coal combustion have led to increased mercury (Hg) concentrations in different environmental media. This review critically evaluates recent developments in technological approaches...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2019.105281
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Bio-accumulation of persistent organic pollutants (POPs) in the environment and in the food chain can lead to high pollutant concentrations in human fat-containing tissues and breast milk. OBJECTIVES:We aimed to identify the maternal characteristics that determined POP concentrations in breast milk of primi...
journal_title:Environment international
pub_type: 杂志文章,多中心研究
doi:10.1016/j.envint.2019.104979
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:We investigated the associations between daily sales of respiratory medication and air pollutants in the Brussels-Capital Region between 2005 and 2011. METHODS:We used over-dispersed Poisson Generalized Linear Models to regress daily individual reimbursement data of prescribed asthma and COPD medication fro...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.06.019
更新日期:2016-09-01 00:00:00
abstract::To enlarge the possibilities of using organisms of the soil fauna to assess the bioaccumulative potential of chemicals, the kinetic of soil cadmium (Cd) transfer to the terrestrial gastropod Helix aspersa was investigated under laboratory conditions during a long-term experiment (6 months). During the exposure phase (...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2006.05.006
更新日期:2006-09-01 00:00:00
abstract::LR- 115 plastic track detectors have been used to measure indoor radon level in some dwellings of Una district, Himachal Pradesh, India. The annual average radon concentration in dwellings in most of the villages falls in the range of the action level recommended by the International Commission on Radiological Protect...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/s0160-4120(02)00012-0
更新日期:2002-04-01 00:00:00
abstract::Five hexachloronorbornene-based flame retardants, Dechlorane Plus (DP), Dechlorane 602 (Dec 602), Dechlorane 603 (Dec 603), Dechlorane 604 (Dec 604) and hexachlorocyclopentadienyl-dibromocyclooctane (HCDBCO), were measured in human milk and maternal serum. Dec 602, Dec 603 and HCDBCO were detected in both sample matri...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.01.010
更新日期:2014-05-01 00:00:00
abstract::Kuala Lumpur has been undergoing rapid urbanisation process, mainly in infrastructure development. The opening of new township and residential in former tin mining areas, particularly in the heavy mineral- or tin-bearing alluvial soil in Kuala Lumpur, is a contentious subject in land-use regulation. Construction pract...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.01.009
更新日期:2017-07-01 00:00:00
abstract::Clean cooking energy strategies are critical for reducing air pollution, improving health, and achieving related Sustainable Development Goals. The recent COVID-19 lockdowns may impact the transition towards clean cooking fuels. The nationwide lockdown is likely to affect key factors such as energy access, income, tra...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2020.106335
更新日期:2021-02-01 00:00:00