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Associations between prenatal and childhood PBDE exposure and early adolescent visual, verbal and working memory.

Abstract：

BACKGROUND:Prenatal and childhood exposure to polybrominated diphenyl ether (PBDE) flame retardants has been inversely associated with cognitive performance, however, few studies have measured PBDE concentrations in samples collected during both prenatal and postnatal periods. METHODS:We examined prenatal (cord) and childhood (ages 2, 3, 5, 7 and 9 years) plasma PBDE concentrations in relation to memory outcomes assessed between the ages of 9 and 14 years. The study sample includes a subset (n = 212) of the African American and Dominican children enrolled in the Columbia Center for Children's Environmental Health Mothers and Newborns birth cohort. We used multivariable linear regression to examine associations between continuous log10-transformed PBDE concentrations and performance on tests of visual, verbal and working memory in age-stratified models. We additionally used latent class growth analysis to estimate trajectories of exposure across early life, which we analyzed as a categorical variable in relation to memory outcomes. We examined interactions between PBDE exposure and sex using cross-product terms. RESULTS:Associations between prenatal exposure and working memory significantly varied by sex (p-interaction = 0.02), with inverse relations observed only among girls (i.e. βBDE-47 = -7.55, 95% CI: -13.84, -1.24). Children with sustained high concentrations of BDEs-47, 99 or 100 across childhood scored approximately 5-8 standard score points lower on tests of visual memory. Children with PBDE plasma concentrations that peaked during toddler years performed better on verbal domains, however, these associations were not statistically significant. CONCLUSIONS:Exposure to PBDEs during both prenatal and postnatal periods may disrupt memory domains in early adolescence. These findings contribute to a substantial body of evidence supporting the developmental neurotoxicity of PBDEs and underscore the need to reduce exposure among pregnant women and children.

journal_name

Environ Int

journal_title

Environment international

authors

Cowell WJ,Margolis A,Rauh VA,Sjödin A,Jones R,Wang Y,Garcia W,Perera F,Wang S,Herbstman JB

doi

10.1016/j.envint.2018.05.004

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

9-16

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(18)30045-X

journal_volume

118

pub_type

杂志文章

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Associations between prenatal and childhood PBDE exposure and early adolescent visual, verbal and working memory.