Chemiluminescence determination of terbutaline sulfate in bovine urine and pharmaceutical preparations based on enhancement of the 2-phenyl-4, 5-di (2-furyl) imidazole-potassium ferricyanide system.

abstract：:A method of analysis of SC-560 (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole) in biological fluids is necessary to study the kinetics of in vitro and in vivo metabolism. A simple high-performance liquid chromatographic method was developed for simultaneous determination of SC-560 and other pr...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Teng XW,Davies NM

更新日期：2004-09-03 00:00:00

abstract：:A sensitive high performance liquid chromatographic (HPLC) assay has been developed and validated for the quantitation of the novel anticancer agent topotecan and topotecan as its lactone plus carboxylate forms in rat and dog plasma. Linear responses in analyte standard peak areas were observed over the concentration ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Rosing H,Doyle E,Beijnen JH

更新日期：1996-11-01 00:00:00

abstract：:The iCE280 Analyzer (iCE280) was evaluated for its potential application as a high-throughput tool to determine pI and separate charge related species using glycosylated, non-glycosylated and pegylated protein therapeutics as models. Resolution was achieved for glycosylated and non-glycosylated molecules, but remained...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Li N,Kessler K,Bass L,Zeng D

更新日期：2007-02-19 00:00:00

abstract：:A method based on capillary electrophoresis with electrochemical detection has been developed for the separation and determination of paeoniflorin, sucrose, paeonoside, glucose, and fructose in Moutan Cortex for the first time. Effects of several important factors such as the concentration of NaOH, separation voltage,...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Chen G,Zhang L,Zhu Y

更新日期：2006-04-11 00:00:00

abstract：:The analysis of carbimazole tablets in The British Pharmacopoeia, 1993, includes a quantitative thin layer chromatography (TLC) determination of methimazole. Repeated analysis of the same samples did not give similar results. The repeatability and reproducibility of the method was studied. It was proved that the resid...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Aletrari M,Kanari P,Partassides D,Loizou E

更新日期：1998-01-01 00:00:00

abstract：:An orthogonal testing protocol was developed and validated to assess the quality of Filgrastim biosimilars. Results were compared to those obtained from the innovator product. Initial screening was carried out using reducing and non-reducing gel electrophoresis. RP-LC was employed for the determination of Filgrastim i...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Shaltout EL,Al-Ghobashy MA,Fathalla FA,Salem MY

更新日期：2014-08-01 00:00:00

abstract：:The inclusion complex formation between Metoprolol tartarata (MeT) and beta-cyclodextrin (beta-CD) has been investigated using hyperchromic shift at lambda(max) 274.4 nm of MeT. Different parameters such as stirring time, solvent composition (aqueous and aqueous/methanol solutions with methanol content up to 50%), pH ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Radulovic DM,Karljikovic-Rajic KD,Lucic BM,Vujic ZB

更新日期：2001-03-01 00:00:00

abstract：:Pharmaceutical excipients containing volatile odor-active molecules can be used in pharmaceutical development to increase patients' compliance. However, capturing the molecular composition of these odor-active substances is challenging. Therefore, guidance for the analytical investigation of these excipients should be...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kiene FE,Pein M,Thommes M

更新日期：2015-06-10 00:00:00

abstract：:The phytochemical research based on ethnopharmacology is considered an effective approach in the discovery of novel chemicals entities with potential as drug leads. Plants/plant extracts/decoctions, used by folklore traditions for treating several diseases, represent a source of chemical entities but no information ar...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Brusotti G,Cesari I,Dentamaro A,Caccialanza G,Massolini G

更新日期：2014-01-01 00:00:00

abstract：:The stability of cisplatin and its monohydrated complex has been studied in blood, plasma and plasma ultrafiltrate at 37 degrees C (pH 7.4). Intact cisplatin and the monohydrated complex were determined by liquid chromatography with post-column derivatization. The half lives for cisplatin and the monohydrated complex ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Andersson A,Ehrsson H

更新日期：1995-04-01 00:00:00

abstract：:Solid phase extraction (SPE) and HPLC were used for simultaneous determination of hesperidin, diosmin and eriocitrin in Iranian lime juice samples. The method involved very simple efficient SPE with polyamide cartridge, the use of mixture of water/acetonitrile/acetic acid (78:19:3, v/v) as a mobile phase at a flow rat...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Saeidi I,Hadjmohammadi MR,Peyrovi M,Iranshahi M,Barfi B,Babaei AB,Dust AM

更新日期：2011-09-10 00:00:00

abstract：:Dolutegravir was approved by USFDA, Canada and European regulatory authorities as antiretroviral medication. In this article, DLG forced degradation studies as per the International Council for Harmonization (ICH) prescribed stress conditions was conducted and the resulting degradants were fully characterized. DLG was...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Saida SJ,Manikandan A,Kaliyaperumal M,Rumalla CS,Khan AA,Jayaraman VB,Yanaka R,Venkat Rao S

更新日期：2019-09-10 00:00:00

abstract：:Values of the ionization constants at 37 °C, which are scarcely reported, are more meaningful for interpreting mechanisms of cellular transport by ionizable molecules and in mechanistic dissolution studies, which are often performed at the biorelevant temperature. An equation was developed where the pK(a) values of dr...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Sun N,Avdeef A

更新日期：2011-09-10 00:00:00

abstract：:Non-covalent interaction of hemicyanine dyes, derivatives of 2,3,3-trimethyl-3H-indolium with bovine serum albumin has been studied by spectral method. For this purpose, three hemicyanine dyes containing N-(2-carboxyethyl)-2,3,3-trimethyl-3H-indolium moiety were synthesized and their UV/Vis and fluorescence spectra, a...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kabatc J,Jurek K,Kostrzewska K,Orzeł Ł

更新日期：2015-10-10 00:00:00

abstract：:A rapid analytical procedure for routine identification and quantification of amoxicillin in premixes by high performance liquid chromatography was developed and tested. The ground premix samples were extracted for 10 min using 100ml extraction mixture water-methanol (800:200, v/v). The extract was analyzed by reverse...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Dousa M,Hosmanová R

更新日期：2005-02-23 00:00:00

abstract：:The aim of the current study was to develop and validate a robust multi-analyte high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for simultaneous quantification of cefepime, meropenem, ciprofloxacin, moxifloxacin, linezolid and piperacillin, which are the most commonly used antibioti...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Paal M,Zoller M,Schuster C,Vogeser M,Schütze G

更新日期：2018-04-15 00:00:00

abstract：:Uridinediphosphoglucuronosyl transferases (UGTs) are a group of membrane bound proteins which catalyze the transfer of glucuronic acid from UDP-glucuronic acid to a wide variety of xenobiotics and drug molecules enabling them to be eliminated. The major UGT isoforms found in the rat are 1A1, 1A6, 2B1 and 2B12. Convent...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Narayanan R,LeDuc B,Williams DA

更新日期：2000-04-01 00:00:00

abstract：:Liquidambar styraciflua L., ALTINGIACEAE, popularly known as sweet gum or alligator tree, is an aromatic tree with a natural distribution in North America and acclimated in Brazil. In traditional medicine, L. styraciflua L is used for the treatment of stomach disorders, wounds, and coughs. The present study was design...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mancarz GFF,Laba LC,da Silva ECP,Prado MRM,de Souza LM,de Souza D,Nakashima T,Mello RG

更新日期：2019-09-10 00:00:00

abstract：:The headspace gas chromatographic method has been widely used to detect volatile metabolites to reflect the growth state of microorganisms, however, it has never been used for the determination of the minimum inhibitory concentration in antibacterial drugs. This paper reports a new method for evaluating the antimicrob...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Li M,Zhang C,Chen G,Nahar L,Sarker SD,Guo M

更新日期：2020-03-20 00:00:00

abstract：:Chronic kidney disease (CKD) is a worldwide public health problem. Uremic retention solutes such as indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are accumulated in CKD patients and are associated with the incidence of CKD progression. Amino acids are the major precursors of uremic retention solutes in gut. The dyna...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Liu Y,Li J,Yu J,Wang Y,Lu J,Shang EX,Zhu Z,Guo J,Duan J

更新日期：2018-02-05 00:00:00

abstract：:GC-MS is one of the recommended analytical techniques for the identification and confirmation of opiates in urine. A method for the qualitative detection and quantitation of codeine and morphine in urine samples by this technique has been developed. This method is also suitable for the detection of their main metaboli...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Solans A,de la Torre R,Segura J

更新日期：1990-01-01 00:00:00

abstract：:QuEChERS sample preparation was optimized using solvent extraction with acetonitrile and dispersive-solid phase extraction with primary and secondary amine sorbents, and validated for high-performance liquid chromatographic determination of nine steroids commonly used to adulterate herbal medicines: such as triamcinol...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Klinsunthorn N,Petsom A,Nhujak T

更新日期：2011-07-15 00:00:00

abstract：:Valproic acid (VA) is a drug widely used to treat epilepsy and bipolar disorder, at recommended serum concentrations ranging form 50 to 100μg ml(-1). A novel option for therapeutic drug monitoring that has been emerging recently its testing using dried blood spots on paper (DBS), but there are no reports of its applic...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Rhoden L,Antunes MV,Hidalgo P,Álvares da Silva C,Linden R

更新日期：2014-08-05 00:00:00

abstract：:Fingolimod (Gilenya; FTY720), has been recently approved for the treatment of multiple sclerosis in Europe and in the USA. In the present study, we have developed and validated a rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to simultaneously quantify FTY720 and FTY720-P in human...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Emotte C,Deglave F,Heudi O,Picard F,Kretz O

更新日期：2012-01-25 00:00:00

abstract：:A field-amplified sample stacking (FASS) and capillary zone electrophoresis (CZE) method is described for the quantification of ambroxol hydrochloride in human plasma, following liquid-liquid extraction in the 96-well format. The separation was carried out at 25 °C in a 31.2 cm × 75 μm fused-silica capillary with an a...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Li J,Bi Y,Wang L,Sun F,Chen Z,Xu G,Fan G

更新日期：2012-07-01 00:00:00

abstract：:The classification of an impurity of a drug substance as genotoxic means that the "threshold of toxicological concern" (TTC) value of 1.5 μg/day intake, considered to be associated with an acceptable risk, should be the admissible limit in the raw material and that leads to new analytical challenges. In this study, re...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： García A,Rupérez FJ,Ceppa F,Pellati F,Barbas C

更新日期：2012-03-05 00:00:00

abstract：:99mTc(V)-oxo complexes of L,L-ethylene dicysteine (L,L-EC) and its di-ester derivative L,L-ethyl cysteinate dimer (L,L-ECD) are useful tracer agents for evaluation of renal function and cerebral blood flow respectively. Labelling of these molecules with a 99mTc(V)-nitrido core instead of the 99mTc(V)-oxo core alters t...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mang'era KO,Bellande E,Pasqualini R,Verbruggen A

更新日期：1996-06-01 00:00:00

abstract：:Although chemotherapy is widely used to treat human cancers, most chemotherapeutic agents only benefit a small fraction of patients because of the heterogeneity of cancers. Therefore, identifying of the sensitivity of cancers toward various chemotherapies would be important for choosing of chemotherapeutic regime. In ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： He DX,Xia YD,Gu XT,Jin J,Ma X

更新日期：2015-01-01 00:00:00

abstract：:The measurement uncertainty (MU) related to analytical results can lead to false decisions in conformity assessment, such as accepting or rejecting incorrectly a medicine lot (consumer's and producer's risks, respectively). These risks can be global or specific. It is important to understand the different types of con...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Separovic L,Rebello Lourenço F

更新日期：2020-05-30 00:00:00

abstract：:Extensive assignments of resonances in the 600 MHz 1H-NMR spectra of cerebrospinal fluid are reported. These have been achieved by the measurement of a combination of two-dimensional experiments comprising homonuclear J-resolved, COSY45, and double-quantum filtered COSY (DQCOSY) spectra. By these means the previous to...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Sweatman BC,Farrant RD,Holmes E,Ghauri FY,Nicholson JK,Lindon JC

更新日期：1993-08-01 00:00:00