Clinical outcome of patients with FIGO stage IA2 squamous cell carcinoma of the uterine cervix.


OBJECTIVE:The objective of this analysis was to present the clinical outcome of the patients with FIGO stage IA2 squamous cell cervical cancer treated at the Department of Obstetrics and Gynecology between 1973 and 2009, and to clarify the discrepancies in clinical guidelines regarding the radicality of treatment applied in patients with stage IA2 squamous cell cervical cancer. METHODS:In our study we enrolled 89 women, diagnosed with FIGO stage IA2 squamous cell microinvasive carcinoma (MIC) in the period 1973-2009. The analysis involved the following parameters women's age at operation, type of operation, cell type, mitotic activity, invasive growth pattern, host defense reaction, lymph-vascular space invasion and patient's survival. Additionally, using the Rainer's scoring system, the prognostic score for each MIC was calculated. RESULTS:The mean women's age at operation was 41.48 ± 10.67 years. The mean depth of invasion was 3.09 ± 1.13 mm, and the mean area of carcinoma 4.05 ± 2.40 mm(2). In 66 (74.2%) women the suggested treatment was conization, according to the Rainer's scoring system and individualization of treatment based on decision of the tumor board. Three of the 89 patients diagnosed with MIC stage IA2 died; only in one patient the cause of death was cervical carcinoma. At the end of the observed period the survival rate was 98.0%. CONCLUSION:We may conclude that conservative management of stage IA2 MIC is safe when exact evaluation of tumor extension and surgical margins of the cone are considered, and results in very low risk of recurrence, lymph node disease, and death caused by cancer. We believe that our experience will contribute to the achievement of the international consensus concerning the treatment of IA2 MIC.


Gynecol Oncol


Gynecologic oncology


Smrkolj S,Pogačnik RK,Slabe N,Rakar S




Has Abstract


2012-01-01 00:00:00














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    abstract:OBJECTIVE:We evaluated the clinical relevance of catenins, cadherins and cell cycle regulators in stage IV or recurrent endometrial carcinoma in a multi-center phase II trial (GOG protocol #119). METHODS:Tissue microarrays of metastatic or recurrent (n=42) tumor were developed and immunohistochemistry was performed. A...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究


    authors: Singh M,Darcy KM,Brady WE,Clubwala R,Weber Z,Rittenbach JV,Akalin A,Whitney CW,Zaino R,Ramirez NC,Leslie KK

    更新日期:2011-11-01 00:00:00

  • Detection of disseminated tumor cells in patients with gynecological cancers.

    abstract:OBJECTIVES:The presence of disseminated tumor cells (DTC) in breast cancer patients is associated with poor prognosis. However, there are limited data about the prevalence and prognostic impact of DTC in patients with gynecological tumors. The aim of this study was to evaluate the presence of DTC in the bone marrow (BM...

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    pub_type: 杂志文章


    authors: Fehm T,Becker S,Bachmann C,Beck V,Gebauer G,Banys M,Wallwiener D,Solomayer EF

    更新日期:2006-12-01 00:00:00

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    abstract::From July 1975 through December 1985, 328 patients with ovarian malignancies were treated. Of these, 302 had epithelial invasive malignancies and constitute the study group. The impact of the operative procedure, findings, and subsequent treatment is evaluated. Patients who underwent extensive debulking procedures suc...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Potter ME,Partridge EE,Hatch KD,Soong SJ,Austin JM,Shingleton HM

    更新日期:1991-03-01 00:00:00

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    abstract:OBJECTIVE:This study describes the surgical treatment and follow-up of 213 patients with primary vulvar cancer; particular attention is given to reconstructive surgical procedures. METHODS:The clinical and pathological parameters of the patients were recorded according to standardized procedures, and the data concerni...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Weikel W,Hofmann M,Steiner E,Knapstein PG,Koelbl H

    更新日期:2005-10-01 00:00:00

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    abstract::Combination chemotherapy consisting of bleomycin, vincristine, mitomycin C, and cisplatin (BOMP) was first applied to an inoperable case (57-year-old) with FIGO stage IV (T3N3 + M1B) squamous cell carcinoma of the vulva. After three courses of BOMP therapy, the patient achieved a complete response with few toxic effec...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Shimizu Y,Hasumi K,Masubuchi K

    更新日期:1990-03-01 00:00:00

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    authors: Gadducci A,Sartori E,Landoni F,Zola P,Maggino T,Colombo N,Fanucchi A,Chiudinelli F,Lapresa M,Maria Ferrero A

    更新日期:2005-07-01 00:00:00

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    pub_type: 杂志文章,多中心研究


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    更新日期:2010-12-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究


    authors: Berek JS,Markman M,Blessing JA,Kucera PR,Nelson BE,Anderson B,Hanjani P

    更新日期:1999-07-01 00:00:00

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    abstract:OBJECTIVE:In cervical cancer patients, dose-volume relationships have been demonstrated for tumor and organs-at-risk, but not for pathologic nodes. The nodal control probability (NCP) according to dose/volume parameters was investigated. MATERIAL AND METHODS:Patients with node-positive cervical cancer treated curative...

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    pub_type: 杂志文章


    authors: Bacorro W,Dumas I,Escande A,Gouy S,Bentivegna E,Morice P,Haie-Meder C,Chargari C

    更新日期:2018-03-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Maggino T,Romagnolo C,Landoni F,Sartori E,Zola P,Gadducci A

    更新日期:1998-03-01 00:00:00

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    更新日期:2012-04-01 00:00:00

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    pub_type: 杂志文章


    authors: McCann GA,Boutsicaris CE,Preston MM,Backes FJ,Eisenhauer EL,Fowler JM,Cohn DE,Copeland LJ,Salani R,O'Malley DM

    更新日期:2013-04-01 00:00:00

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    authors: Gil OD,Lee C,Ariztia EV,Wang FQ,Smith PJ,Hope JM,Fishman DA

    更新日期:2008-02-01 00:00:00

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    authors: Fujii S

    更新日期:2008-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Crozier MA,Copeland LJ,Silva EG,Gershenson DM,Stringer CA

    更新日期:1989-11-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Hardy RD,Bell JG,Nicely CJ,Reid GC

    更新日期:2005-03-01 00:00:00

  • Type II endometrial cancer in Hispanic women: tumor characteristics, treatment and survival compared to non-Hispanic white women.

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Mahdi H,Hou H,Kowk LL,Moslemi-Kebria M,Michener C

    更新日期:2014-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Duck L,Devogelaer JP,Persu A,Berlière M,Caussin E,Baurain JF,Machiels JP

    更新日期:2005-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Donahue RN,McLaughlin PJ,Zagon IS

    更新日期:2011-08-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Goodman MT,McDuffie K,Hernandez B,Bertram CC,Wilkens LR,Guo C,Seifried A,Killeen J,Le Marchand L

    更新日期:2001-05-01 00:00:00

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章


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    更新日期:2006-11-01 00:00:00

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Dioun SM,Vilardo N,Goldberg GL,Gressel GM

    更新日期:2019-11-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2008-05-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2012-05-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Sandruck J,Escobar P,Lurain J,Fishman D

    更新日期:2004-02-01 00:00:00

  • Prognostic value of pre-treatment human papilloma virus DNA status in cervical cancer.

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章


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    更新日期:2018-01-01 00:00:00

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    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Smith HO,Blessing JA,Vaccarello L

    更新日期:2002-01-01 00:00:00

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vergote I,du Bois A,Floquet A,Rau J,Kim JW,Del Campo JM,Friedlander M,Pignata S,Fujiwara K,Colombo N,Mirza MR,Monk BJ,Tsibulak I,Calvert PM,Herzog TJ,Hanker LC,Meunier J,Lee JY,Bologna A,Carrasco-Alfonso MJ,Harter

    更新日期:2019-11-01 00:00:00

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Guminski AD,Balleine RL,Chiew YE,Webster LR,Tapner M,Farrell GC,Harnett PR,Defazio A

    更新日期:2006-02-01 00:00:00

  • Travel distance, hospital volume and their association with ovarian cancer short- and long-term outcomes.

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    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Knisely A,Huang Y,Melamed A,Tergas AI,St Clair CM,Hou JY,Khoury-Collado F,Ananth CV,Neugut AI,Hershman DL,Wright JD

    更新日期:2020-08-01 00:00:00