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Increased expression of P-cadherin is an indicator of poor prognosis in breast cancer: a systematic review and meta-analysis.

Abstract：

PURPOSE:P-cadherin (CDH3), located at 16q22.1 belonging to classical cadherin family, is a calcium-dependent glycoprotein associated with cell to cell adhesion, migration, and invasion in cancer. This meta-analysis was conducted to examine the prognostic utility of P-cadherin expression in breast cancer (BC). METHODS:A comprehensive literature search was carried out using the available databases to obtain relevant research articles to test the relationship between P-cadherin and BC. Correlation of P-cadherin expression and disease-free survival (DFS) or overall survival (OS) was tested using hazard ratio (HR), relative risk (RR) at 95% confidence interval (CI) by univariate and/or multivariate analysis. A total of 11 studies from 7 countries were found to be relevant and were further subjected to statistical analysis to find an association between the P-cadherin expression with BC. Additionally, we have also performed a co-relation analysis of P-cadherin expression with GOBO and Cancertool in breast cancer using publicly available breast cancer datasets. RESULTS:Our study shows that P-cadherin expression is significantly linked with poor prognosis in the various subtypes of BC. The HR for OS and DFS was 1.87 (95% CI = 1.48-2.36) and 1.64 (95% CI = 1.18-2.27) respectively. CONCLUSIONS:In this meta-analysis, we identified a positive correlation between the overexpression of P-cadherin and BC. Our study demonstrates that P-cadherin overexpression can be used as a prognostic indicator in BC.

journal_name

Breast Cancer Res Treat

journal_title

Breast cancer research and treatment

authors

Sridhar S,Rajesh C,Jishnu PV,Jayaram P,Kabekkodu SP

doi

10.1007/s10549-019-05477-5

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

301-313

issue

2

eissn

0167-6806

issn

1573-7217

pii

10.1007/s10549-019-05477-5

journal_volume

179

pub_type

杂志文章,meta分析

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