Kinetics and action of N-methylthiotetrazole in volunteers and patients. Population-based clinical comparisons of antibiotics with and without this moiety.

Abstract:

:Normal volunteers and patients were studied to determine the relative importance of NMTT and patient risk factors in the production of hypoprothrombinemia. The normal volunteers demonstrated in vivo NMTT production, but the order of magnitude (cefoperazone, moxalactam, and cefotetan in descending order) was different from the usual order of clinical risk. In patients, there was not a NMTT-concentration-versus-effect relationship. Patients who were vitamin K deficient were more sensitive to lower NMTT concentrations than those with normal vitamin K status. In surveillance studies, NMTT-containing antibiotics were nor more frequently associated with hypoprothrombinemia or bleeding than antibiotics that lack this moiety.

journal_name

Am J Surg

authors

Schentag JJ,Welage LS,Williams JS,Wilton JH,Adelman MH,Rigan D,Grasela TH

doi

10.1016/s0002-9610(88)80210-1

subject

Has Abstract

pub_date

1988-05-31 00:00:00

pages

40-4

issue

5A

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(88)80210-1

journal_volume

155

pub_type

杂志文章
  • Carcinoma of the lip.

    abstract::(1) Carcinoma of the lip occurs predominantly in men in their seventh and eighth decades of life. (2) Epidermoid carcinoma is the most common malignant lip tumor. (3) Metastases to cervical lymph nodes are uncommon. (4) Elective neck dissection is not indicated. (5) Therapeutic radical neck dissection can benefit the ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(79)90427-6

    authors: Heller KS,Shah JP

    更新日期:1979-10-01 00:00:00

  • The utility of CT scan for the diagnostic evaluation of acute abdominal pain.

    abstract::AbdCT for the evaluation of AAP in the ED in the US may be excessive and is potentially (although rarely) misleading and harmful. A selective policy of 'AbdUS first' combined with an observation unit and/or surgeon evaluation prior to AbdCT is preferred to a 'routine AbdCT' policy. Repeated AbdCTs for abdominal pain a...

    journal_title:American journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.amjsurg.2019.02.003

    authors: Bax T,Macha M,Mayberry J

    更新日期:2019-05-01 00:00:00

  • Analysis of 18 recent cases of penetrating injuries to the common and internal carotid arteries.

    abstract::Penetrating injuries to the common and internal carotid artery carry the unique potential for irreversible neurologic damage, respiratory collapse, and exsanguination. This study analyzes a recent 4 year experience with 18 cases of penetrating injury to the carotid artery to identify the factors influencing surgical d...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(88)80363-5

    authors: Meyer JP,Walsh J,Barrett J,Schuler JJ,Durham JR,Eldrup-Jorgensen J,Schwarcz TH,Flanigan DP

    更新日期:1988-08-01 00:00:00

  • Does delayed gastric emptying contribute to gastroesophageal reflux disease?

    abstract::We studied 76 patients with symptoms of heartburn, regurgitation, or both and 38 asymptomatic control subjects by measuring the gastric emptying of technetium-99m-labeled oatmeal. In addition, we performed 24-hour esophageal pH monitoring and manometric studies of the esophagus on all study participants. Endoscopy was...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(89)90422-4

    authors: Schwizer W,Hinder RA,DeMeester TR

    更新日期:1989-01-01 00:00:00

  • The role of same-sex mentorship and organizational support in encouraging women to pursue surgery.

    abstract:INTRODUCTION:While women represent approximately half of all medical students, only 38% of general surgery residents are women. The objective of this study is to explore how access to mentors and organizational support affects career choices. METHODS:In June of 2016, a survey was sent to medical students at a single i...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2017.07.005

    authors: Faucett EA,McCrary HC,Milinic T,Hassanzadeh T,Roward SG,Neumayer LA

    更新日期:2017-10-01 00:00:00

  • Saphenous vein bypass graft to left main coronary artery.

    abstract::The first reported aorto-left main coronary artery saphenous vein bypass for an aberrant left main coronary artery arising from the anterior sinus of Valsalva is presented. Late follow-up revealed a normal stress test, and cardiac catheterization revealed the left system to be entirely supplied by the graft. ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(77)90349-x

    authors: Sacks JH

    更新日期:1977-08-01 00:00:00

  • Options in the management of perforations of the esophagus.

    abstract::A study of 90 cases of esophageal perforation in the antibiotic era emphasizes individualized treatment and options of therapy based on a fundamental understanding of modifying pathophysiologic factors. If the patient is seen during the first 24 hours, surgical repair and irrigating tube drainage continue to be the tr...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(86)90144-3

    authors: Brewer LA 3rd,Carter R,Mulder GA,Stiles QR

    更新日期:1986-07-01 00:00:00

  • Ultrasonic imaging during biliary and pancreatic surgery.

    abstract::Real-time ultrasound scanning was used during operations on the biliary tract and pancreas. The principal application in biliary surgery was to evaluate the common bile duct for presence of calculi. Our initial experience indicates that operative ultrasonography compares favorably with operative cholangiography. In pa...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(81)90017-9

    authors: Sigel B,Coelho JC,Spigos DG,Donahue PE,Wood DK,Nyhus LM

    更新日期:1981-01-01 00:00:00

  • Surgical registrars' perceptions of surgical training and capacity in Zambia: Results from three COSECSA affiliated training hospitals.

    abstract:BACKGROUND:Surgery is a vital component of a comprehensive health system, but there are often personnel limitations in resource constrained areas. Zambia provides post graduate surgical training through two systems to help address this shortage. However, no studies have analyzed surgical trainees' perceptions of these ...

    journal_title:American journal of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.amjsurg.2017.07.023

    authors: Freitas DM,Munthali J,Musowoya J,Ismail H,Herbst A,Chikoya L,Dhage S,Hopkins MA

    更新日期:2018-04-01 00:00:00

  • A cost analysis of a pancreatic cancer screening protocol in high-risk populations.

    abstract:BACKGROUND:Pancreatic cancer is the 4th leading cause of cancer death in the United States. A screening protocol is needed to catch early-stage, resectable disease. This study suggests a protocol for high-risk individuals and assesses the cost in the context of the Affordable Care Act. METHODS:Medicare and national av...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2014.11.017

    authors: Bruenderman E,Martin RC 2nd

    更新日期:2015-09-01 00:00:00

  • Cholecystectomy for acute cholecystitis: timing of operation, bacteriologic aspects, and postoperative course.

    abstract::There is still considerable controversy among surgeons regarding the most opportune moment for surgical intervention in the case of acute cholecystitis. For this reason, 471 patients cholecystectomized for acute cholecystitis from 1970 through 1982 were studied. During the first period, there were two types of surgica...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(84)90334-9

    authors: Sianesi M,Ghirarduzzi A,Percudani M,Dell'Anna B

    更新日期:1984-11-01 00:00:00

  • Controversies in the management of pancreatic pseudocysts.

    abstract::Review of the diagnosis and treatment of patients with pancreatic pseudocysts over the past 8 years has led us to three conclusions regarding controversial aspects of their treatment. We found that patients who present with chronic pseudocysts can be identified with the help of computerized axial tomography and prompt...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(88)80275-7

    authors: Mullins RJ,Malangoni MA,Bergamini TM,Casey JM,Richardson JD

    更新日期:1988-01-01 00:00:00

  • Improved positioning of the upper arm graft fistula for hemodialysis.

    abstract::An improved technique is presented for placement of the upper arm graft fistula for hemodialysis. This approach brings the graft anteriorly across the front of the biceps muscle, thereby allowing easier puncture and greater comfort for the patient during dialysis treatment. ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(86)90478-2

    authors: Gifford RM

    更新日期:1986-03-01 00:00:00

  • Is thyroid frozen section too much for too little?

    abstract:BACKGROUND:The role of frozen section (FS) in thyroid disease is controversial. The goal of this study was to identify a cohort of patients who may or may not benefit from FS. METHODS:Two hundred thirty-one patients who underwent thyroidectomy were evaluated in regard to fine-needle aspiration (FNA), FS, and the exten...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(02)01074-7

    authors: Richards ML,Chisholm R,Bruder JM,Strodel WE

    更新日期:2002-12-01 00:00:00

  • A comprehensive characterization of lymphoepithelial cyst associated with the pancreas.

    abstract:BACKGROUND:Lymphoepithelial cyst of the pancreas is a rare but distinctive cystic lesion lined by a mature, keratinizing squamous epithelium and surrounded by lymphoid tissue. METHODS:To gain more insights into this entity, we describe 5 examples of lymphoepithelial cyst of the pancreas (2 of which were briefly descri...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(99)80247-5

    authors: Truong LD,Stewart MG,Hao H,Yutani C,Jordan PH

    更新日期:1995-07-01 00:00:00

  • Risk factors for surgical site infection after stoma closure comparison between pursestring wound closure and conventional linear wound closure: Propensity score matching analysis.

    abstract:PURPOSE:Stoma closure has been associated with a high rate of surgical site infection (SSI) and the optimal skin closure method is still controversial. The aim of this study was to compare the short-term and long-term outcomes between the conventional linear closure (CC) and the persestring closure (PC) using propensit...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2017.09.031

    authors: Yamamoto M,Tanaka K,Masubuchi S,Ishii M,Hamamoto H,Suzuki S,Ueda Y,Okuda J,Uchiyama K

    更新日期:2018-01-01 00:00:00

  • Never giving up: outcomes and presentation of emergency general surgery in geriatric octogenarian and nonagenarian patients.

    abstract:BACKGROUND:Aging of the population necessitates consideration of the increasing number of older adults requiring emergency care. The objective of this study was to compare outcomes and presentation of octogenarian and/or nonagenarian emergency general surgery (EGS) patients with younger adults. METHODS:Based on a stan...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2016.01.021

    authors: Shah AA,Zafar SN,Kodadek LM,Zogg CK,Chapital AB,Iqbal A,Greene WR,Cornwell EE 3rd,Havens J,Nitzschke S,Cooper Z,Salim A,Haider AH

    更新日期:2016-08-01 00:00:00

  • Serologic determinants of survival in patients with squamous cell carcinoma of the head and neck.

    abstract::Specific circulating serum proteins may reflect unique properties governing the growth and progression of head and neck cancers. One hundred three previously untreated patients with squamous cell carcinoma of the head and neck were prospectively evaluated for serum IgA, IgG, and IgM and C1q-binding macromolecules. Imm...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(05)80560-4

    authors: Clayman GL,Savage HE,Ainslie N,Liu FJ,Schantz SP

    更新日期:1990-10-01 00:00:00

  • Surgical implications of a left-sided gallbladder.

    abstract:BACKGROUND:A left-sided gallbladder in a normally positioned liver is considered to be a very uncommon anomaly. Laparoscopic cholecystectomy can be performed safely, but bile duct injury is not unusual. It is associated with anomalous intrahepatic portal and biliary systems which impacts any form of partial hepatectomy...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2012.10.035

    authors: Strong RW,Fawcett J,Hatzifotis M,Hodgkinson P,Lynch S,O'Rourke T,Slater K,Yeung S

    更新日期:2013-07-01 00:00:00

  • Closure of craniofacial defects after cancer resection.

    abstract::Resection of malignancies of the upper face and skull base may result in complex bone and soft tissue defects. To better define the optimal management of these defects, we conducted a retrospective review of 75 consecutive patients who underwent closure of 76 craniofacial defects after malignant tumor excision from 19...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(91)90160-f

    authors: Wornom IL 3rd,Neifeld JP,Mehrhof AI Jr,Young HF,Chinchilli VM

    更新日期:1991-10-01 00:00:00

  • Enlarged parathyroid glands discovered in normocalcemic patients during thyroid surgery.

    abstract:BACKGROUND:This is a retrospective study analyzing data of normocalcemic patients with enlarged parathyroid glands discovered during thyroid surgery and comparing it with data of patients operated on for proved primary hyperparathyroidism. METHODS:The records of patients with enlarged parathyroid glands (group 1) and ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2007.01.033

    authors: Abboud B,Sleilaty G,Braidy C,Ghorra C,Abadjian G,Tohme C,Noun R,Sarkis R

    更新日期:2008-01-01 00:00:00

  • Cholecystostomy for noninflammatory disease.

    abstract::Cholecystostomy in patients with noninflammatory disease of the biliary tract has rarely been evaluated. Our experience with 124 patients suggests that, in addition to being helpful in inflammatory conditions, cholecystostomy is helpful in performing cholangiography, in removing stones and in decompressing an otherwis...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(81)90192-6

    authors: Beart RW Jr,Mroz CT

    更新日期:1981-03-01 00:00:00

  • The impact of diabetes on outcome in traumatically injured patients: an analysis of the National Trauma Data Bank.

    abstract:BACKGROUND:Studies on stress hyperglycemia in trauma patients have largely ignored diabetes, a potential confounder. The purpose of this study was to assess the relationship between diabetes and outcome in trauma patients. METHODS:Data were obtained from the National Trauma Data Bank (version 4.0). The primary outcome...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2006.08.031

    authors: Kao LS,Todd SR,Moore FA

    更新日期:2006-12-01 00:00:00

  • High-resolution computed tomography accurately predicts resectability in hilar cholangiocarcinoma.

    abstract:INTRODUCTION:Despite the use of radiologic, endoscopic, and laparoscopic staging techniques, the rate of nontherapeutic laparotomies in patients with hilar cholangiocarcinoma remains high. This study evaluated the accuracy of preoperative high-resolution computed tomography (HRCT) to determine resectability in this set...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2006.10.024

    authors: Aloia TA,Charnsangavej C,Faria S,Ribero D,Abdalla EK,Vauthey JN,Curley SA

    更新日期:2007-06-01 00:00:00

  • Presidential address: Eponyms in biliary tract surgery.

    abstract::A selected group of men whose eponyms are currently used in biliary tract surgery are described. The eponyms chosen comprise two areas: gross anatomy (Glisson, Wirsung, Santorini, Winslow, Heister, and Vater) and operative anatomy (Kocher, Courvoisier, Morison, Hartmann, Calot, Roux, and Oddi). A brief review of bilia...

    journal_title:American journal of surgery

    pub_type: 历史文章,杂志文章

    doi:10.1016/0002-9610(79)90290-3

    authors: Wood M

    更新日期:1979-12-01 00:00:00

  • Effect of preoperative irradiation on healing of low colorectal anastomoses.

    abstract::The effect of preoperative irradiation on the healing of low colorectal anastomoses was studied experimentally. In 12 dogs in whom preoperative irradiation of 4,000 rads was given before low colorectal stapled anastomosis was performed, anastomotic leakage occurred in 66 percent. More than half of the anastomotic leak...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(84)90099-0

    authors: Morgenstern L,Sanders G,Wahlstrom E,Yadegar J,Amodeo P

    更新日期:1984-02-01 00:00:00

  • Response to radiotherapy of head and neck tumors in AIDS patients.

    abstract::Initial manifestations of AIDS in the head and neck area occur frequently. In fact, up to 40 percent of patients may have involvement of the head and neck. The most common malignancies are Kaposi's sarcoma and non-Hodgkin's lymphoma. Since AIDS-related malignancies are a relatively new problem for radiation oncologist...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/0002-9610(89)90021-4

    authors: Hommel DJ,Brown ML,Kinzie JJ

    更新日期:1987-10-01 00:00:00

  • Prolonged enteral nutrition in malnourished patients with nonelemental feeding. Reappraisal of surgical technique, safety, and costs.

    abstract::In a 2 year period, 60 consecutive feeding enterostomies were placed in malnourished patients. The major complication rate was 1.6 percent. Total complications were 8 percent. Thirty day mortality was 13 percent. Nearly all patients were given isosmotic nonelemental diets. The incidence of diarrhea was 2 percent with ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(85)80102-1

    authors: Hinsdale JG,Lipkowitz GS,Pollock TW,Hoover EL,Jaffe BM

    更新日期:1985-03-01 00:00:00

  • Regulation of gastric acid secretion by secretin and serotonin.

    abstract::We have tested the interaction between serotonin and secretin in pentagastrin-induced gastric acid secretion in six dogs prepared with Thomas gastric and duodenal cannulas. We further examined the effect of methysergide, a serotonin antagonist, on gastric acid secretion. The intravenous administration of serotonin or ...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/s0002-9610(85)80007-6

    authors: Mate L,Sakamoto T,Greeley GH Jr,Thompson JC

    更新日期:1985-01-01 00:00:00

  • Is breast cancer sentinel lymph node mapping valuable for patients in their seventies and beyond?

    abstract:BACKGROUND:Axillary lymph node dissection (ALND) is performed less commonly for the axillary staging of elderly patients because it is felt to uncommonly alter therapy. Sentinel lymph node (SLN) dissection can accomplish axillary staging with less morbidity, but it is unclear if it alters subsequent therapy. METHODS:R...

    journal_title:American journal of surgery

    pub_type: 杂志文章

    doi:10.1016/j.amjsurg.2005.03.028

    authors: McMahon LE,Gray RJ,Pockaj BA

    更新日期:2005-09-01 00:00:00