Abstract：
OBJECTIVE:To determine whether Charlson comorbidity index (CCI) predicts the postoperative complications after percutaneous nephrolithotomy (PCNL) and could be a plausible option to avoid surgery and its potential risks in elderly patients with significant comorbidites. METHODS:The data from 283 elderly patients (age ≥ 60 years) who underwent PCNL in 4 large referral hospitals were reviewed in the present multicenter study. For each patient, we evaluated pre-existing comorbidities and calculated the CCI score. The patients were classified to 3 CCI score categories (0, 1, ≥ 2) and compared regarding the stone-free and complications rates. RESULTS:The mean patient age was 64.7, 65.6, and 67.7 years in the 3 groups. The stone-free rate after primary PCNL was 85.7% in group 1, 86.1% in group 2, and 75.0% in group 3. These rates increased to 90.8%, 95.4%, and 83.9% after a second intervention (P = .049). The overall postoperative complication rate was 38.8%. The most common complication was hemorrhage necessitating blood transfusion in 34 patients (12%), and we found an increased risk of hemorrhage associated with the CCI score (P = .011). Life-threatening medical complications developed in 7.6% of the patients in group 1, 12% of the patients in group 2, and 28.6% of the patients in group 3 (P = .001). A multivariate logistic regression analysis showed that a high CCI score, bleeding, and operative time had significant influence on the postoperative medical complication in this population. CONCLUSION:Conservative management of asymptomatic large kidney stones appears to be a safe alternative to PCNL in elderly patients with significant comorbidites.
journal_name
Urologyjournal_title
Urologyauthors
Resorlu B,Diri A,Atmaca AF,Tuygun C,Oztuna D,Bozkurt OF,Unsal Adoi
10.1016/j.urology.2011.10.060subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1042-7issue
5eissn
0090-4295issn
1527-9995pii
S0090-4295(11)02599-4journal_volume
79pub_type
杂志文章,多中心研究相关文献
UROLOGY文献大全abstract：OBJECTIVE:To describe our ultrasound technique for confirming intraoperative, antegrade-placed ureteral stent position during laparoscopic pyeloplasty. BACKGROUND:Disadvantages of retrograde stent placement include the need to reposition the patient into and out of the lithotomy position. Antegrade stent placement can...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.12.019
更新日期：2018-04-01 00:00:00
abstract：:Circumcision is generally undertaken for 3 reasons; first, as an item of religious practice, typically neonatally, although occasionally transpubertally, as a rite of passage; second, as a prophylactic measure against future ailments (for the reduction in the risk of penile cancer, urinary tract infection, and sexuall...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.10.005
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVES:Penile verrucous carcinoma is characterized by aggressive local growth and a low metastatic potential. Lower abdominal aortic infusion chemotherapy has the main advantage of delivering a very high concentration of an anticancer drug to the whole pelvic area, including the penis, and is especially suitable to...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/s0090-4295(03)00008-6
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVES:Contrary to previous belief, the existence of a muscularis mucosa in the human urinary bladder has now been well described. Although the degree of development of this structure seems variable, it can frequently be used to differentiate two levels within the subepithelial connective tissue: the lamina propria...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(95)96490-8
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVES:To develop a method for assessing absolute renal function (as well as morphology) in children, using gamma camera imaging of intravenously injected technetium-99m (99mTc) dimercaptosuccinic acid (DMSA). METHODS:Forty-five children (ages 1 week to 10 years; mean, 2.0 years) were imaged using a planar techniq...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(99)80461-0
更新日期：1996-03-01 00:00:00
abstract：OBJECTIVES:To assess the effects of finasteride on angiogenetic and hypoxia markers in benign prostatic hyperplasia. METHODS:A total of 178 patients aged 51 to 85 years (mean 68.7) with benign prostatic hyperplasia and awaiting transurethral prostate resection were prospectively randomized into a group of patients rec...
journal_title：Urology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.urology.2006.03.038
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVES:The combined use of total prostate-specific antigen (PSA), clinical stage, and Gleason score accurately predicts final pathologic stage for men with clinically localized prostate cancer. Recently, the free/ total PSA ratio has been proposed as an adjunct for early detection of prostate cancer. We examined th...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/s0090-4295(96)00610-3
更新日期：1996-12-01 00:00:00
abstract：:A great variety of self-inflicted foreign bodies have been removed from the lower urinary tract and male external genitalia. These foreign bodies were inserted or applied for autoerotic, psychiatric, therapeutic, or no definite reasons by the patient. Most patients were too ashamed to admit they had inserted or applie...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(85)90245-6
更新日期：1985-07-01 00:00:00
abstract：OBJECTIVES:To investigate whether the excitatory amino acid receptor agonists can activate the paraventricular nucleus of the hypothalamus (PVN) and induce penile erections in the rat. METHODS:Male adult Sprague-Dawley rats were used. A 26-gauge needle was inserted into the corpus cavernosum to monitor the intracavern...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(03)00411-4
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:To determine if the performance of vaginal distension (VD) in different estrous cycle phases affects the successful induction of stress urinary incontinence in mice. METHODS:Female virgin C57BL/6 mice were distributed into 4 groups according to their estrous cycle phase: proestrus, estrus, metestrus, or dies...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.12.028
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:To investigate the antimuscarinic effect of oxybutynin in the rat detrusor muscle after estrogen pretreatment because, to our knowledge, no study has been done on the interaction of estrogen with antimuscarinic drugs. Estrogen has been shown to affect muscarinic receptors in the detrusor muscle of animals. I...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2004.10.069
更新日期：2005-04-01 00:00:00
abstract：:A wealth of clinical evidence supports the view that muscarinic receptor antagonists are effective in the treatment of overactive bladder. However, treatment-limiting adverse effects such as dry mouth, constipation, and blurred vision have restricted the usefulness of previously available agents, such as oxybutynin. A...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/s0090-4295(99)00492-6
更新日期：2000-05-01 00:00:00
abstract：:Hemorrhagic cystitis is a recognized acute complication of cyclophosphamide (Cytoxan) therapy in the treatment of malignant disease. More recently, lower dose, long-term cyclophosphamide therapy has been used in the treatment of autoimmune diseases including rheumatoid arthritis. In 3 patients hemorrhagic cystitis dev...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(79)90526-0
更新日期：1979-12-01 00:00:00
abstract：OBJECTIVE:To establish a score threshold that constitutes a clinically relevant change for each domain of the Expanded Prostate Cancer Index Composite (EPIC) Short Form (EPIC-26). Although its use in clinical practice and clinical trials has increased worldwide, the clinical interpretation of this 26-item disease-speci...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.08.044
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To confirm the role of cathelicidin (LL-37) in the internalization of bacille Calmette-Guérin (BCG) into bladder cancer cells. METHODS:Enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction analysis evaluated the changes in protein and messenger ribonucleic acid (RNA) expressio...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.12.028
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:Ischemia is a potential contributor to decline of function after partial nephrectomy (PN), although loss of parenchymal mass related to excision and reconstruction appears to be a more significant factor. However, loss of parenchymal mass could also be due to global effects of ischemia leading to parenchymal ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2015.02.040
更新日期：2015-06-01 00:00:00
abstract：:We report an unusual case of an accessory or duplicated urethra. This case is unique because of its association with multiple urologic anomalies which made management and diagnosis of this condition unusual. The unusual combination of right ectopic ureter and left renal and ureteral agenesis in association with the ac...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(75)90633-0
更新日期：1975-10-01 00:00:00
abstract：OBJECTIVE:To explore relationships between dose to periprostatic anatomic structures and erectile dysfunction (ED) outcomes in an institutional cohort treated with prostate brachytherapy. METHODS:The Sexual Health Inventory for Men (SHIM) instrument was administered for stage cT1-T2 prostate cancer patients treated wi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2019.08.014
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy and toxicity of three-dimensional conformal radiotherapy (3D-CRT) in the adjuvant and salvage setting after radical prostatectomy (RP). METHODS:From 1986 to 1997, 38 patients received adjuvant 3D-CRT, with a median time from RP to 3D-CRT of 2.8 months, and 57 patients were treated w...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(03)00127-4
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVES:Diabetes mellitus (DM) is an important cause of organic impotence. It is estimated that 35% to 75% of diabetic patients are impotent. In the present study we investigated the effect of experimentally induced diabetes (streptozocin 60 mg/kg, intraperitoneally, for 9 weeks) on sexual behavior and compared it t...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/S0090-4295(99)80073-9
更新日期：1995-04-01 00:00:00
abstract：:To implicate further the surface mucoprotein as the factor responsible for preventing bacterial attachment to the bladder mucosa, rabbit urothelium was severely disrupted and allowed to regenerate for varying periods of time. Quantitative measurements of the attachment of 14C-labeled Escherichia coli were correlated w...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(77)90245-x
更新日期：1977-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the safety and short-term efficacy of complete sacrocolpopexy mesh excision with concomitant autologous fascia sacrocolpopexy. METHODS:A retrospective cohort study of patients undergoing complete sacrocolpopexy mesh excision and concomitant autologous fascia sacrocolpopexy from March 2013 to Sept...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.04.040
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:To compare the use of radiofrequency (RF) and electrocautery in partial nephrectomy without renal artery clamping for bleeding and tissue destruction. METHODS:Sixteen adult rabbits were randomized into two groups. Partial nephrectomy using a monopolar RF device without renal artery clamping was performed in...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.05.034
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVES:To assess the effect of triamcinolone administration on the serum prostate-specific antigen (PSA) response and the time to progression in patients with androgen-independent prostate cancer (AIPC). METHODS:Patients with AIPC were prospectively treated with oral triamcinolone 4 mg twice daily, and their serum...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.11.004
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To provide data on physical activity among those with and without overactive bladder (OAB) in a large, ethnically diverse U.S. sample. METHODS:A cross-sectional survey was conducted via the Internet among 10,000 men and women aged 18-70 (2000 African Americans, 2000 Hispanics, and 6000 whites) using the lowe...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2013.05.035
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:To assess prescribing and refilling trends of narcotics in postoperative urology patients at our institution. Although the opioid epidemic remains a public health threat, no series has assessed prescribing patterns across urologic surgery disciplines following discharge. METHODS:All urologic surgeries were r...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.11.070
更新日期：2021-01-23 00:00:00
abstract：OBJECTIVES:To demonstrate the existence of a prostate-bladder neural reflex that might help clarify a neurologic mechanism for voiding dysfunction associated with chronic prostatitis/chronic pelvic pain syndrome. METHODS:Experiments were performed on anesthetized adult male Wistar rats. Repeated cystometry was used to...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.02.063
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVES:Transformation of normal epithelium into cancer cells involves epigenetic and genetic changes and modifications in nuclear structure and tissue architecture. To evaluate nuclear morphometric alterations and clinicopathologic features for organ- vs nonorgan-confined prostate carcinoma (PCa) prediction. METHO...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.09.060
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the effects of different degrees of intratesticular hematoma (ITH), a major consequence of blunt testis trauma, on testis microstructure and function. We determined a cutoff point for significant vs nonsignificant ITH. METHODS:Seventy male rats were divided into 7 equal groups. The control group ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2018.05.005
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVES:Frequently, statistically significant prognostic factors are reported in published studies with suggestions that disease management should be modified. However, the clinical relevance of such factors is rarely quantified. We evaluated the accuracy of predicting the need for invasive treatment among patients ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.11.049
更新日期：2006-05-01 00:00:00
