Abstract：
OBJECTIVES:Contrary to previous belief, the existence of a muscularis mucosa in the human urinary bladder has now been well described. Although the degree of development of this structure seems variable, it can frequently be used to differentiate two levels within the subepithelial connective tissue: the lamina propria and the submucosa. The present study evaluates whether this morphologic feature is potentially useful for the identification of two populations with Stage T1 bladder cancer: those with tumor invasion confined to the lamina propria (pT1A) and those with tumors infiltrating into the submucosa (pT1B). METHODS:A series of 170 Stage T1 papillary bladder tumors was analyzed pathologically to identify the level of subepithelial connective tissue invasion. Both the reproducibility of such a differentiation and its prognostic implication were evaluated using Kaplan-Meier survival estimates and the Cox regression model. RESULTS:In specimens from transurethral resection, categorization into T1A or T1B could be performed in 98 of 170 cases (58% of specimens). Such differentiation proved to be of prognostic value with significantly different 5-year survivals between the two subcategories (pT1A [n = 50] vs pT1B [n = 49]) (log-rank, P < 0.02). Cox's regression analysis of pT1 subcategory and grade was performed in the 99 cases in which the differentiation between pT1A/pT1B could be made. This demonstrated that the depth of subepithelial connective tissue invasion was an independent prognostic factor (P < 0.05). CONCLUSIONS:The depth of tumor infiltration can be assessed in a considerable proportion of Stage T1 bladder neoplasms. The present study validates the prognostic significance of such a distinction both by Mantel-Haenszel life table method and Cox's regression analysis.
journal_name
Urologyjournal_title
Urologyauthors
Angulo JC,Lopez JI,Grignon DJ,Sanchez-Chapado Mdoi
10.1016/s0090-4295(95)96490-8subject
Has Abstractpub_date
1995-01-01 00:00:00pages
47-53issue
1eissn
0090-4295issn
1527-9995pii
S0090-4295(95)96490-8journal_volume
45pub_type
杂志文章相关文献
UROLOGY文献大全abstract：OBJECTIVES:To evaluate the safety and efficacy of 1.9 µm Vela laser in treatment of primary non-muscle-invasive bladder cancer. METHODS:The data of the patients with non-muscle-invasive bladder cancer treated by either en bloc transurethral resection with 1.9 µm Vela laser (n = 26) or conventional transurethral resect...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.11.030
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of reconstruction of penile urethra with the 3-dimensional (3-D) porous bladder acellular matrix (BAM) in a rabbit model. MATERIALS AND METHODS:In 30 male rabbits, a ventral urethral mucosal defect (1.5 × 0.8 cm) was created. Substitution urethroplasty was performed with 5% peracetic a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2014.07.044
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVES:To investigate the feasibility, safety, and efficacy of perineal cutaneous application of capsaicin as a test for the diagnosis, as well as a potential therapeutic tool, in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS:We recruited 22 patients (mean age 34.5 years, range ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.11.028
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To describe epidemiologic patterns, stage at presentation, histology, and treatment differences associated with Hispanic men diagnosed with testicular germ cell tumor (TGCT). Hispanics are the fastest growing demographic in the United States and reports suggest that the incidence of TGCT is rising most rapidl...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.08.059
更新日期：2018-02-01 00:00:00
abstract：:Genital cutaneous involvement with Crohn disease is an uncommon complication which has been described only recently. A case is presented of a young man with Crohn disease involving the penile and scrotal skin four years after total colectomy for Crohn disease. The histopathology and management are discussed. While the...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(80)90376-3
更新日期：1980-06-01 00:00:00
abstract：OBJECTIVES:A critical issue in the management of prostate cancer is the ability to distinguish patients at risk of disease recurrence. The aim of this study was to determine whether specific physical alterations of chromosome 8 may be associated with disease recurrence and poor outcome using postoperative prostate-spec...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(00)00468-4
更新日期：2000-05-01 00:00:00
abstract：OBJECTIVES:To investigate the mechanism of gefitinib resistance in renal cell carcinoma (RCC) cells. Although epidermal growth factor receptor (EGFR) is frequently overexpressed in RCC, gefitinib, a tyrosine kinase inhibitor of EGFR, has only a limited antitumor effect on RCC. METHODS:The effects of gefitinib on the a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.12.058
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVES:To review our experience to better define pediatric renal cell carcinoma (RCC). Pediatric RCC is rare, and recent data suggest it may be a unique disease. METHODS:A retrospective review was conducted of hospital and pathology records from 1965 to 2003. Patients with RCC were identified, and the clinical and...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2005.06.104
更新日期：2005-12-01 00:00:00
abstract：:Internal ureteral stents have become an integral part of urologic practice to relieve intrinsic as well as extrinsic upper urinary tract obstruction. Missed internal ureteral stents is a serious potential complication that is associated with increased patient morbidity and is especially a problem in developing countri...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2020.04.048
更新日期：2020-07-01 00:00:00
abstract：:Insertion of either a semirigid or inflatable penile prosthesis at the completion of surgery for various malignancies was performed. Twelve men had implants and were followed at least one year with excellent results. Careful preoperative sexual counseling with the patient's spouse is recommended and adds immeasureably...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(82)90637-9
更新日期：1982-09-01 00:00:00
abstract：:A patient with an ileal conduit diversion after cystectomy for carcinoma of the bladder is seen with cirrhosis and portal hypertension. Massive bleeding from the peristomal varices developed. Our experiences with conservative treatment is outlined. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(78)90439-9
更新日期：1978-12-01 00:00:00
abstract：OBJECTIVES:To determine whether nadir prostate-specific antigen (PSA) levels within 12 months (nadir PSA12) after completion of radiotherapy (RT) can be used as an early marker of recurrence risk. METHODS:A total of 4839 patients were treated with RT and without hormonal therapy from 1986 to 1995 for Stage T1-T2 prost...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2006.08.1056
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:To determine whether measurement of telomere DNA content (TC) in prostate biopsy tissue predicts prostate-specific antigen (PSA) recurrence in men after undergoing radical prostatectomy for prostate cancer. METHODS:Slot blot titration assay was used to quantitate TC in archived diagnostic prostate needle bio...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2009.04.032
更新日期：2010-03-01 00:00:00
abstract：:Despite the emergence of different devices in the treatment of postprostatectomy urinary incontinence, the AMS 800 (American Medical Systems, Minnetonka, MN) remains the gold standard for the treatment of stress urinary incontinence in men. We reviewed the current literature regarding the indications, surgical princip...
journal_title：Urology
pub_type： 杂志文章,评审
doi：10.1016/j.urology.2016.01.016
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVES:To evaluate periurethral silicone injection in the treatment of female stress urinary incontinence due to intrinsic sphincter deficiency (ISD) and assess whether coexisting urethral hypermobility has an impact on treatment outcome. METHODS:A total of 29 female patients with stress urinary incontinence under...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01996-9
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the statistical association between routine home health use after prostatectomy, short-term surgical outcomes, and payments. METHODS:We identified all men who underwent a robotic radical prostatectomy from April 1, 2014, to October 31, 2015, in the Michigan Urological Surgery Improvement Collabor...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2017.11.004
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship of lower urinary tract symptoms (LUTS) to urinary tract infection, prostatitis, sexually transmitted infection, lifetime sexual partner count, and recreational drug use in a population of men who have sex with men. LUTS in men are a source of considerable morbidity, distress, a...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2011.07.1412
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVES:To correlate the abnormalities on computed tomography, magnetic resonance imaging, and bone scan with fluorinated deoxyglucose positron emission tomography (FDG-PET) in patients with progressive metastatic prostate cancer, using a lesion-by-lesion analysis, and to preliminarily explore post-treatment changes...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(02)01509-1
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:To determine the efficacy of computed tomography of the chest (CTC) and plain radiograph (CXR) in the initial staging process of testicular germ cell tumors. METHODS:The medical records of 362 patients with testicular germ cell tumor treated at our center between January 1980 and August 1993 were reviewed wi...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(94)80139-8
更新日期：1994-08-01 00:00:00
abstract：:A rare case of renal xanthine stone in association with the Lesch-Nyhan syndrome is presented. The xanthine stone is thought to be a complication of allopurinol therapy. ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(85)90256-0
更新日期：1985-07-01 00:00:00
abstract：OBJECTIVES:To review the feasibility and outcome of retroperitoneoscopic nephrectomy (RPN) for pyonephrotic nonfunctioning kidneys. METHODS:RPN for pyonephrotic nonfunctioning kidneys was used in 52 patients from July 2001 to May 2007. Percutaneous nephrostomy drainage was instituted in 46 patients because of sepsis b...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2008.07.054
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the feasibility of pure robotic natural orifice translumenal endoscopic surgery (R-NOTES) nephrectomy. METHODS:Two R-NOTES nephrectomy approaches were attempted in 3 female cadavers. A single-port device was inserted through an incision in the posterior vaginal fornix. In the first approach, the ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2012.11.083
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVES:With the widespread use of prostate-specific antigen (PSA)-based screening, there is now concern about the overdiagnosis and overtreatment of men with low-risk prostate cancer (PCa). One of the most difficult aspects of PCa management is a balance of the often-competing goals of cancer control with functiona...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2007.12.016
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To review the long-term outcome of selective renal arterial embolization (SAE) in treating renal angiomyolipomas (AMLs) in both elective and emergency settings. MATERIALS AND METHODS:Between October 1988 and September 2008, 27 patients (28 renal units) were treated with SAE, either on an emergency basis for ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2010.08.040
更新日期：2011-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the relationship between changes in weight, waist circumference (WC), metabolic syndrome (MetS), and prostate growth over 5 years in the adult population. MATERIALS AND METHODS:Data were collected from 1088 adult men (age ≥40 years) without history of prostate cancer who underwent more than 2 gen...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2016.09.044
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:To prospectively investigate whether vardenafil can effectively treat patients for whom sildenafil (100 mg) has failed. The introduction of two new oral phosphodiesterase type 5 inhibitors (tadalafil and vardenafil) raises the question of whether the new agents will permit us to treat sildenafil nonresponder...
journal_title：Urology
pub_type： 临床试验,杂志文章
doi：10.1016/j.urology.2006.03.005
更新日期：2006-08-01 00:00:00
abstract：:Cytologic differences in the urine of 6 patients with transitional cell carcinoma in situ (CIS) of the urinary bladder with and without prostatic duct involvement are described. In the former group, there was an admixture of CIS cells along with many bizarre malignant cells which increased with time and showed maligna...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/0090-4295(76)90203-x
更新日期：1976-05-01 00:00:00
abstract：OBJECTIVE:To evaluate clinical and patient-reported urinary and sexual outcomes after a long-segment stricture repair using the 1-sided urethral dissection, penile invagination, and dorsal buccal mucosa graft onlay technique described by Kulkarni et al. METHODS:Patients from 4 institutions after single-stage repairs f...
journal_title：Urology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.urology.2017.08.029
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To evaluate feasibility of percutaneous nephrolithotomy (PCNL) for complex nephrolithiasis in patients 80 years of age and older compared to younger individuals. METHODS:From an institutional IRB-approved database, 1,647 patients were identified who underwent PCNL from 1999 to 2019. Patients were stratified ...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/j.urology.2019.08.044
更新日期：2019-12-01 00:00:00
abstract：:A patient with a durable, complete, local and pulmonary remission of a metastatic sarcomatoid carcinoma of the bladder treated with gemcitabine and cisplatin is presented. Sarcomatoid carcinoma arising in the bladder is a rare and notoriously aggressive variant of urothelial carcinoma for which an effective systemic t...
journal_title：Urology
pub_type： 杂志文章
doi：10.1016/s0090-4295(01)01343-7
更新日期：2001-11-01 00:00:00
