Abstract：
:Parkinson's disease (PD) is a neurodegenerative pathology of the central nervous system, mainly involving the selective and progressive loss of dopaminergic neurons from the substantia nigra, resulting in motor and non-motor symptoms. PD remains an incurable ailment; thus, treatments are limited to symptom alleviation. With long-term use, conventional treatments can become inefficient, often triggering possible side effects. Considering these drawbacks, drug discovery constantly turns to nature as a source of efficient therapeutics. Thus, this review explores animal venoms as a rich source of bioactive compounds with potent neuropharmacological profiles for the development of effective adjuvant treatments with fewer side effects, ultimately aiming for the neuroprotection of dopaminergic neurons and the symptomatic relief of PD.
journal_name
Drug Discov Todayjournal_title
Drug discovery todayauthors
de Oliveira Amaral H,Monge-Fuentes V,Biolchi Mayer A,Alves Campos GA,Soares Lopes K,Camargo LC,Ferroni Schwartz M,Galante P,Mortari MRdoi
10.1016/j.drudis.2019.09.004subject
Has Abstractpub_date
2019-11-01 00:00:00pages
2202-2211issue
11eissn
1359-6446issn
1878-5832pii
S1359-6446(19)30348-4journal_volume
24pub_type
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