Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA.

Abstract:

:Chronic infection with hepatitis B virus (HBV) often leads to the development of liver cancer and cirrhosis, creating immense sociological, clinical and economic burdens worldwide. Although current anti-HBV medications manage to control the disease progression and help restore normal liver functions, they often fail to eliminate the virus completely. A major reason for this failure is the presence of a stable viral genome in the hepatocyte nucleus: the covalently closed circular DNA (cccDNA). Targeting HBV cccDNA is a promising approach that could lead to a complete cure. Here, we review various research approaches that are directed toward eliminating HBV cccDNA. This is a brief, yet comprehensive, summary of current state-of-the-art developments in this emerging area of interest.

journal_name

Drug Discov Today

journal_title

Drug discovery today

authors

Ahmed M,Wang F,Levin A,Le C,Eltayebi Y,Houghton M,Tyrrell L,Barakat K

doi

10.1016/j.drudis.2015.01.008

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

548-61

issue

5

eissn

1359-6446

issn

1878-5832

pii

S1359-6446(15)00030-6

journal_volume

20

pub_type

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