Abstract:
:Carbohydrate derived fulvic acid (CHD-FA) is a heat stable low molecular weight, water soluble, cationic, colloidal material with proposed therapeutic properties. The aim of this study was to evaluate the antifungal activity of CHD-FA against Candida albicans, and to characterize its mode of action. A panel of C. albicans isolates (n = 50) derived from a range of clinical specimens were grown planktonically and as biofilms, and the minimum inhibitory concentrations determined. Scanning electron microscopy was performed to examine ultrastructural changes and different cell membrane assays were used to determine its mode of action. In addition, the role of C. albicans biofilm resistance mechanisms were investigated to determine their effects on CHD-FA activity. CHD-FA was active against planktonic and sessile C. albicans at concentrations 0.125 and 0.25% respectively, and was shown to be fungicidal, acting through disruption of the cell membrane activity. Resistance mechanisms, including matrix, efflux, and stress, had a limited role upon CHD-FA activity. Overall, based on the promising in vitro spectrum of activity and minimal biofilm resistance of the natural and cheap antiseptic CHD-FA, further studies are required to determine its applicability for clinical use.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Sherry L,Jose A,Murray C,Williams C,Jones B,Millington O,Bagg J,Ramage Gdoi
10.3389/fmicb.2012.00116subject
Has Abstractpub_date
2012-03-29 00:00:00pages
116issn
1664-302Xjournal_volume
3pub_type
杂志文章abstract::Based on the Stable Ecotype Model, evolution leads to the divergence of ecologically distinct populations (e.g., with different niches and/or behaviors) of ecologically interchangeable membership. In this study, pyrosequencing was used to provide deep sequence coverage of Synechococcus psaA genes and transcripts over ...
journal_title:Frontiers in microbiology
pub_type: 杂志文章
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更新日期:2015-06-22 00:00:00
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pub_type: 杂志文章
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abstract::Approximately 36.7 million people were living with the human immunodeficiency virus (HIV) at the end of 2016 according to UNAIDS, representing a global prevalence rate of 0.8%. In Brazil, an HIV prevalence of 0.24% has been estimated, which represents approximately 830,000 individuals living with the virus. As a touri...
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pub_type: 杂志文章
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journal_title:Frontiers in microbiology
pub_type: 杂志文章
doi:10.3389/fmicb.2012.00363
更新日期:2012-10-12 00:00:00
abstract::Baiyunbian baijiu, the most popular miscellaneous-flavor baijiu in China, has been widely consumed for decades. Similar to many Chinese baijiu, Baiyunbian baijiu is fermented in five successive batches every year. Sensory analysis demonstrated that the raw baijiu obtained from the last two fermentation batches always ...
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journal_title:Frontiers in microbiology
pub_type: 杂志文章,评审
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abstract:Rationale:Although frequently retrieved in tracheal secretions of critically ill patients on mechanical ventilation, the existence of pneumonia caused by coagulase-negative staphylococci (CoNS) remains controversial. Objective:To assess whether Staphylococcus haemolyticus (S. haemolyticus) inoculated in mice's trachea...
journal_title:Frontiers in microbiology
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journal_title:Frontiers in microbiology
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journal_title:Frontiers in microbiology
pub_type: 已发布勘误
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更新日期:2016-11-29 00:00:00
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