Antibiotic therapy in cystic fibrosis. Evaluation of efficacy.

Abstract:

:Eradication of the bacterial pathogen, resolution of the local and systemic inflammatory signs, and recovery of organ function are the main criteria by which antibiotic treatment is evaluated. In cystic fibrosis (CF) the pathogen is seldom eradicated and systemic markers of inflammation are not always present. The main criterion for assessing the results of antimicrobial therapy in CF is therefore clinical improvement. The use of clinical scoring systems and double-blind design in therapeutic trials can reduce bias in evaluation of outcome. Assessment of the contribution of antibiotic therapy to the outcome requires greater knowledge of the role of bacterial infection in the pathogenesis of pulmonary exacerbations and could be improved by the development of quantifiable markers in respiratory secretions for inflammation.

journal_name

Chest

journal_title

Chest

authors

Levy J

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

150S-156S

issue

2 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)38827-4

journal_volume

94

pub_type

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