Abstract：
INTRODUCTION:Overactive bladder (OAB) is a common condition, increasing with age and affecting quality of life. While numerous OAB drugs are available, persistence is low. We evaluated evidence published since 2012 to determine if newer drugs provided better efficacy and harm profiles. METHODS:We searched MEDLINE and the Cochrane Library from 2012 to September 2018 using terms for included drugs and requested information from manufacturers of included drugs. We performed dual review of all systematic review processes, evaluated study quality, and conducted meta-analyses using random effects models. RESULTS:In addition to 31 older studies, we included 20 trials published since 2012 (N = 16,478; 4 good, 11 fair, and 5 poor quality). Where statistical differences were found, they were clinically small (reductions of < 0.5 episodes/day). Solifenacin plus mirabegron improved efficacy outcomes over monotherapy with either drug, but significantly increased constipation compared with solifenacin and dry mouth compared with mirabegron. Solifenacin reduced incontinence over mirabegron and tolterodine and urgency episodes over tolterodine. Mirabegron did not differ from tolterodine in efficacy but had significantly lower incidence of dry mouth than solifenacin or tolterodine. Fesoterodine showed significant improvements but also anticholinergic effects vs. tolterodine. Oxybutynin, solifenacin, and tolterodine had similar efficacy, but dry mouth led to greater discontinuation with oxybutynin. Blurred vision, cardiac arrhythmia, and dizziness were uncommon. CONCLUSION:New evidence confirms small, but clinically uncertain, differences among monotherapies and also between combination and monotherapy, regardless of statistical significance. While drugs mainly differed in incidence of dry mouth or constipation, none provided improved efficacy without increased harms.
journal_name
Int Urogynecol Jjournal_title
International urogynecology journalauthors
Hsu FC,Weeks CE,Selph SS,Blazina I,Holmes RS,McDonagh MSdoi
10.1007/s00192-019-04022-8subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1603-1617issue
10eissn
0937-3462issn
1433-3023pii
10.1007/s00192-019-04022-8journal_volume
30pub_type
杂志文章,meta分析abstract：INTRODUCTION AND HYPOTHESIS:Polypropylene is a base polymer used in biomaterial applications, including sutures and mesh products, for the treatment of pelvic organ prolapse, stress urinary incontinence, and hernia repairs. Previous studies have dismissed the value of formulation additives employed in polypropylene, an...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-016-3131-4
更新日期：2017-02-01 00:00:00
abstract：:A pubic cartilaginous cyst is a rare condition and is considered a result of degenerative changes in the symphysis pubis, mainly described in elderly multiparous women. There are only a few reported cases in the literature, and patients presented most frequently with a painful vaginal/vulvar mass. This case report is ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-014-2523-6
更新日期：2015-03-01 00:00:00
abstract：:In July of 2011 the U.S. Food and Drug Administration (FDA) released a safety communication entitled "UPDATE on Serious Complications Associated with Transvaginal Placement of Surgical Mesh for Pelvic Organ Prolapse." The stated purpose of this communication is to inform health care providers and patients that serious...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-011-1581-2
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The effect of incontinence pessaries for urine incontinence (UI) has previously been described in studies from high-income countries, where they have been documented to reduce urinary leakage significantly. However, there is a profound literature gap in these data in low- and middle-income c...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-019-03980-3
更新日期：2020-06-01 00:00:00
abstract：:Obstetric fistula is the presence of a hole between a woman's genital tract and either the urinary or the intestinal tract. Better knowledge of the risk factors for obstetric fistula could help in preventing its occurrence. The purpose of this study was to assess the characteristics of obstetric fistula patients. We c...
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-011-1622-x
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Entry into the peritoneal cavity can be challenging in patients with posthysterectomy prolapse; however, it is important for vaginal surgeons to be able to enter the peritoneal cavity using various techniques to perform an intraperitoneal vaginal vault suspension. METHODS:We present surgica...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-017-3267-x
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Evidence suggests that OAB (overactive bladder) can occur alongside disorders of the colon, such as irritable bowel syndrome (IBS). Moreover, patients with constipation are more likely to develop OAB symptoms than those without. Anticholinergic medications (AcH) are commonly used for treatin...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-014-2527-2
更新日期：2015-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The aim was to develop a nomogram based on clinical and surgical factors to predict the likelihood of voiding dysfunction after surgery for deep endometriosis. METHODS:This was a retrospective study of 789 patients (training set) who underwent surgery for deep endometriosis with colorectal ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-020-04428-9
更新日期：2020-07-11 00:00:00
abstract：:Reports have shown that high-energy pelvic trauma might be associated with advanced pelvic organ prolapse in conjunction with other causes. We report the case of a 21-year-old nulliparous, premenopausal, non-overweight woman with no predisposing factors for prolapse who developed stage IV massive pelvic organ prolapse...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-010-1320-0
更新日期：2011-06-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Modern classifications of pelvic floor movements are based on pelvic floor assessment in a static midsagittal plane. This study presents a new and potentially useful 3D noninvasive tool for studying pelvic floor mobility in women with pelvic organ prolapse (POP). MATERIALS AND METHODS:Thirt...
journal_title：International urogynecology journal
pub_type： 临床试验,杂志文章
doi：10.1007/s00192-016-2948-1
更新日期：2016-07-01 00:00:00
abstract：:One of the rarely cited complications of the use of alloplastic materials in pelvic floor surgery is dyspareunia of the partner caused by prominence or vaginal exposure of the sling material. Even though this entity is real and an important problem, it is rarely reported in literature. We report six cases of partner d...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-011-1498-9
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The purpose of this study was to apply a human factors research approach to identify flow disruptions, deviations in the optimal course of care, in robotic abdominal sacrocolpopexy procedures with the ultimate goal of developing system interventions to improve the safety and efficiency of ro...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-019-03929-6
更新日期：2019-12-01 00:00:00
abstract：INTRODUCTION:With the publication of the updated US Food and Drug Administration (FDA) communication in 2011 on the use of transvaginal placement of mesh for pelvic organ prolapse (POP) it is appropriate to now review recent studies of good quality on POP to assess the safety and effectiveness of treatment options and ...
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-012-2025-3
更新日期：2013-05-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Our aim was to validate the Brazilian Portuguese version of the International Federation of Gynecology and Obstetrics (FIGO) Assessment Scoring System (FASS) to identify and quantify signs and symptoms related to pelvic floor dysfunction. METHODS:One hundred and seventy-nine women aged 18-8...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-018-3789-x
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The prevalence of levator avulsion after vaginal delivery ranges from 10 to 30 %. To our knowledge, no previous studies have used anorectal manometry (AM) to assess this injury's impact on the functionality of the anal sphincter complex. We hypothesized that women with levator avulsion have ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-014-2623-3
更新日期：2015-07-01 00:00:00
abstract：:Pelvic reconstructive surgeons have suspected for over a century that childbirth-related trauma plays a major role in the aetiology of female pelvic organ prolapse. Modern imaging has recently allowed us to define and reliably diagnose some of this trauma. As a result, imaging is becoming increasingly important, since...
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-011-1459-3
更新日期：2011-10-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:This study assessed the safety and efficacy of vaginal extraperitoneal uterosacral ligament suspension (VEULS) with anterior overlay mesh versus sacrocolpopexy (SCP) for posthysterectomy vault prolapse. METHODS:This was a multicenter randomized trial of women with posthysterectomy vault pro...
journal_title：International urogynecology journal
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00192-018-3687-2
更新日期：2018-11-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:In order to assess the outcome following surgery for urinary incontinence (UI) and pelvic organ prolapse (POP) the importance of patient-reported outcome measures, in addition to the clinical objective measures, has been recognised. The International Consultation on Incontinence has initiate...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-015-2840-4
更新日期：2016-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Stress urinary incontinence (SUI) may appear after the correction of pelvic organ prolapse (POP). The aim of this study was to externally validate a described predictive model for de novo SUI and to assess its clinical performance when used as a diagnostic test. METHODS:This was a retrospec...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-018-3805-1
更新日期：2019-10-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:A great variety of conservative and surgical procedures to correct vaginal vault prolapse have been reported. The aim of this study was to describe practice pattern variation-the difference in care that cannot be explained by the underlying medical condition-among Dutch gynecologists regardi...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-018-3832-y
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:No measurements are available for diagnosing the extent of obstetric lacerations. The primary aim of this study was to evaluate the relation between the anovaginal distance (AVD) measured with transperineal ultrasound immediately after delivery and external anal sphincter injury. A secondary...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-018-3838-5
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:Urinary incontinence (UI) is common among the elderly, but the literature is sparse on the surgical treatment of UI among the elderly. This systematic review aims to assess the effectiveness of surgical interventions as treatment for urinary incontinence in the elderly population ≥65 years o...
journal_title：International urogynecology journal
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00192-014-2573-9
更新日期：2015-08-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The objective of this video is to demonstrate a variety of available techniques that can be used in the management of acute presacral bleeding. METHODS:In this video, we demonstrate different methods for the management of presacral bleeding utilizing a fresh frozen cadaver. RESULTS:Presacr...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-019-03995-w
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:This study aims to determine what women with overactive bladder (OAB) perceive as 'cure', assesses treatment acceptability and adverse events. It also determines impact on quality of life (QoL) and correlates it with expectations from therapy. METHODS:In 153 women with predominant OAB sympt...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-009-1049-9
更新日期：2010-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The aim of this study was to compare the results of pelvic organ prolapse repair using a capturing device-guided transvaginal mesh in a single- vs multicenter setting. METHODS:One hundred and twelve women operated by two surgeons at one center (2-year follow-up) were compared with 207 women...
journal_title：International urogynecology journal
pub_type： 杂志文章,多中心研究
doi：10.1007/s00192-017-3364-x
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:We describe the rationale and methodology for a study comparing mind-body treatment and pharmacotherapy in women with urgency urinary incontinence (UUI). To explore brain associations in UUI, a subset of patients will also undergo functional magnetic resonance imaging (fMRI). We hypothesize ...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-016-3169-3
更新日期：2017-06-01 00:00:00
abstract：:Vaginal hysterectomy is the oldest and least invasive of the hysterectomy techniques and fulfills the evidence-based requirements as the preferred route of hysterectomy for benign gynecologic disease. Currently, vaginal hysterectomy is commonly utilized for treating uterine prolapse, but despite proven safety and effe...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-014-2459-x
更新日期：2014-09-01 00:00:00
abstract：:Clinical manifestations of vesicouterine fistulas, a rare complication of cesarean section, include amenorrhea and cyclic hematuria (menouria) without urinary incontinence, a triad collectively known as "Youssef's syndrome." Fistulas affecting the uterus usually reside above the isthmus or at the cervix and have a dis...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-012-1849-1
更新日期：2013-04-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:To evaluate the effects of sacral neuromodulation (SNM) on pregnancy and the impact of delivery on SNM function. METHODS:A systematic search was conducted through January 2016. We selected studies including women who had SNM and a subsequent pregnancy. RESULTS:Out of 2,316, eight studies w...
journal_title：International urogynecology journal
pub_type： 杂志文章,评审
doi：10.1007/s00192-017-3272-0
更新日期：2017-09-01 00:00:00
abstract：INTRODUCTION AND HYPOTHESIS:The aim of the present study was to determine possible correlations between mesh retraction after anterior vaginal mesh repair and de novo stress urinary incontinence (SUI), overactive bladder (OAB), and vaginal pain symptoms. METHODS:One hundred and three women with symptomatic prolapse of...
journal_title：International urogynecology journal
pub_type： 杂志文章
doi：10.1007/s00192-013-2131-x
更新日期：2013-12-01 00:00:00
