A novel CDK-2 homolog identified in lamprey, Lampetra japonica, with roles in apoptosis.


:CDK-2, a member of the cyclin-dependent kinase family, plays an important role in many cell processes, such as cell cycle regulation, cell growth and differentiation, and cell apoptosis. Lampreys belong to the most primitive vertebrates, and there is no report about the CDK-2 gene in lampreys at present. In this study, a CDK-2-like gene sequence and deduced amino acid sequence were identified in Japanese lamprey (Lampetra japonica, L. japonica). The CDK-2-like gene has about 80% similarity with its homologs in jaw vertebrates. The polyclonal antibody against CDK-2-like was well prepared, and the results showed that CDK-2-like was highly expressed in the gonad tissue of lampreys. Apoptosis could reduce the expression of CDK-2-like in lymphocytes of lamprey, while overexpression of CDK-2-like could inhibit apoptosis. In addition, inhibition of CDK-2-like activity was able to trigger out apoptosis and also helped apoptotic inducer actinomycin D (Act-D) to induce apoptosis. These results suggest that CDK-2-like identified from lamprey may play a crucial role in apoptosis of jawless vertebrates.


Fish Physiol Biochem


Xu Y,Tian Y,Zhao H,Zheng N,Ren K,Li Q




Has Abstract


2019-12-01 00:00:00














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    abstract::The pseudobranch in rainbow trout was investigated in order to clarify its metabolic and physiological function. Contents of lactate, glycogen, and glycerides and activities of carbonic anhydrase (CA), lactate dehydrogenase (LDH), and 3-hydroxy-acyl CoA dehydrogenase (HAD) were measured and compared with those in the ...

    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Dimberg K

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    authors: Weng WY,Wu T,Chen WQ,Liu GM,Osatomi K,Su WJ,Cao MJ

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Yebra-Pimentel ES,Reis B,Gessner J,Wuertz S,Dirks RPH

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Du J,Chen X,Wang J,Chen H,Yue W,Lu G,Wang C

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Hosseinifard SM,Ahmadpour A,Mojazi Amiri B,Razeghi Mansour M,Ebrahimpour A

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Goksøyr A,Larsen HE

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Dawood MA,Koshio S,Ishikawa M,El-Sabagh M,Yokoyama S,Wang WL,Yukun Z,Olivier A

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Kiessling A,Larsson L,Kiessling KH,Lutes PB,Storebakken T,Hung SS

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    authors: Saligaut C,Bennani S,Bailhache T

    更新日期:1993-07-01 00:00:00

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    pub_type: 杂志文章


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    authors: Kuz'mina VV,Ushakova NV

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    authors: Ling Q,Hong F

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    authors: Aparecida Perna S,Fernandes MN

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


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    authors: Wang H,Wu T,Qin F,Wang L,Wang Z

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Penghan LY,Pang X,Fu SJ

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    journal_title:Fish physiology and biochemistry

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    pub_type: 杂志文章


    authors: Panicz R,Sadowski J,Drozd R

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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Rebl A,Brietzke A,Goldammer T,Seyfert HM

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    pub_type: 杂志文章


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    journal_title:Fish physiology and biochemistry

    pub_type: 杂志文章


    authors: Gingerich AJ,Suski CD

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