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A novel CDK-2 homolog identified in lamprey, Lampetra japonica, with roles in apoptosis.

Abstract：

:CDK-2, a member of the cyclin-dependent kinase family, plays an important role in many cell processes, such as cell cycle regulation, cell growth and differentiation, and cell apoptosis. Lampreys belong to the most primitive vertebrates, and there is no report about the CDK-2 gene in lampreys at present. In this study, a CDK-2-like gene sequence and deduced amino acid sequence were identified in Japanese lamprey (Lampetra japonica, L. japonica). The CDK-2-like gene has about 80% similarity with its homologs in jaw vertebrates. The polyclonal antibody against CDK-2-like was well prepared, and the results showed that CDK-2-like was highly expressed in the gonad tissue of lampreys. Apoptosis could reduce the expression of CDK-2-like in lymphocytes of lamprey, while overexpression of CDK-2-like could inhibit apoptosis. In addition, inhibition of CDK-2-like activity was able to trigger out apoptosis and also helped apoptotic inducer actinomycin D (Act-D) to induce apoptosis. These results suggest that CDK-2-like identified from lamprey may play a crucial role in apoptosis of jawless vertebrates.

journal_name

Fish Physiol Biochem

journal_title

Fish physiology and biochemistry

authors

Xu Y,Tian Y,Zhao H,Zheng N,Ren K,Li Q

doi

10.1007/s10695-019-00683-w

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1829-1843

issue

6

eissn

0920-1742

issn

1573-5168

pii

10.1007/s10695-019-00683-w

journal_volume

45

pub_type

杂志文章

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