Abstract：
:The goals of this work were to isolate and identify an anti-algal compound from extracts of Artemisia annua and study its mode of action on Microcystis aeruginosa. The anti-algal compound was isolated from the extracts using column chromatography and activity-guided fractionation methods. Artemisinin with strong anti-algal activity was identified by gas chromatography-mass spectrometry and (1)H Nuclear Magnetic Resonance. The EC(50) of artemisinin on M. aeruginosa was 3.2mg L(-1). Artemisinin decreased the soluble protein content and increased the superoxide dismutase activity and ascorbic acid content of M. aeruginosa, but exerted no effect on soluble sugar content. The results suggested the mode of action of artemisinin on algae may primarily be the increasing level of reactive oxygen species in algae cells. The results of our research could aid in the development of new anti-algal substances and lead to further study of mechanisms of inhibitory effect on algae.
journal_name
Chemospherejournal_title
Chemosphereauthors
Ni L,Acharya K,Hao X,Li Sdoi
10.1016/j.chemosphere.2012.05.009subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1051-7issue
9eissn
0045-6535issn
1879-1298pii
S0045-6535(12)00606-6journal_volume
88pub_type
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