Management of Androgen Deprivation Therapy-Associated Hot Flashes in Men With Prostate Cancer.

Abstract:

PROBLEM IDENTIFICATION:To determine best practices for managing hot flashes associated with androgen deprivation therapy (ADT) in men with prostate cancer. LITERATURE SEARCH:The CINAHL®, Embase®, PsycINFO®, PubMed®, and Scopus® databases were used to identify randomized controlled trials (RCTs) and quasiexperimental studies published between January 1994 and June 2018. DATA EVALUATION:Using the Cochrane Handbook for Systematic Reviews of Interventions, the authors reviewed 15 studies examining the effects of pharmacologic or complementary and alternative medicine interventions on ADT-associated hot flashes in men with prostate cancer. SYNTHESIS:Pharmacologic interventions (e.g., cyproterone, medroxyprogesterone, megestrol acetate) showed some promise for reducing hot flashes but were associated with side effects and risks. Acupuncture demonstrated potential benefit in reducing hot flashes without side effects. IMPLICATIONS FOR RESEARCH:Evidence is insufficient to support interventions for ADT-associated hot flashes in men with prostate cancer. Future RCTs should be sufficiently powered, include a control group, and use standardized outcome measures.

journal_name

Oncol Nurs Forum

journal_title

Oncology nursing forum

authors

Qan'ir Y,DeDeaux D,Godley PA,Mayer DK,Song L

doi

10.1188/19.ONF.E107-E118

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

E107-E118

issue

4

eissn

0190-535X

issn

1538-0688

journal_volume

46

pub_type

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