Efficacy and safety of recombinant human interleukin-11 in the treatment of acute leukaemia patients with chemotherapy-induced thrombocytopenia: A systematic review and meta-analysis.

Abstract:

RATIONALE, AIMS, AND OBJECTIVES:Current meta-analysis was conducted aiming to assess the efficacy and safety of recombinant human interleukin-11 (rhIL-11) in the treatment of acute leukaemia (AL) patients with chemotherapy-induced thrombocytopenia (CIT). METHODS:We searched PubMed, Embase, Chinese National Knowledge Infrastructure database (CNKI), Cochrane Library, and Wan Fang Database on 4 July 2018. RESULTS:Ten randomized controlled trials (RCTs) and two observational studies were included, which involved 754 AL patients with CIT. Pooled analysis demonstrated that rhIL-11 was beneficial on CIT: recovery time of platelet count to 50 × 109 /L [weight mean difference (WMD) = -4.19 days; 95% CI: -5.01, -3.37], recovery time of platelet count to 100 × 109 /L (WMD = -4.45 days; 95% CI: -4.85, -4.06), platelet transfusion volume (WMD = -6.14 U; 95% CI: -9.20, -3.09), and the rate of haemorrhage (RR = 0.46; 95% CI: 0.36 to 0.61). Most adverse events associated with rhIL-11 were mild to moderate. CONCLUSION:Our findings suggest that rhIL-11 is effective and safe in the treatment of CIT in patients with AL.

journal_name

J Eval Clin Pract

authors

Liu Z,Wang Y,Yan J,Liu J,Chen B,Zhang L,Cheng L

doi

10.1111/jep.13152

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

262-271

issue

1

eissn

1356-1294

issn

1365-2753

journal_volume

26

pub_type

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