Mild hypothermia decreases arrhythmia susceptibility in a canine model of global myocardial ischemia*.

Abstract:

OBJECTIVES:Although the majority of sudden cardiac arrests occur in patients with ischemic heart disease, the effect of therapeutic hypothermia on arrhythmia susceptibility during acute global ischemia is not well understood. While both ischemia and severe hypothermia are arrhythmogenic, patients undergoing therapeutic hypothermia do not have an increase in arrhythmias, despite the fact that most sudden cardiac arrest occur in the setting of ischemia. We hypothesized that mild hypothermia induced prior to myocardial ischemia and reperfusion will have a beneficial effect on ischemia-related arrhythmia substrates. DESIGN:We developed a model of global ischemia and reperfusion in the canine wedge preparation to study the transmural electrophysiologic effects of ischemia at different temperatures. SETTING:Animal study. SUBJECTS:Male mongrel dogs. INTERVENTIONS:Canine left ventricle wedge preparations at 1) control (36°C) or 2) mild hypothermia, to simulate temperatures used in therapeutic hypothermia (32°C), were subjected to 15 mins of no-flow ischemia and subsequently reperfused. MEASUREMENTS AND MAIN RESULTS:Optical action potentials were recorded spanning the transmural wall of left ventricle. Action potential duration for epicardial, mid-myocardial, and epicardial cells was measured. Transmural dispersion of repolarization and conduction velocity were measured at baseline, during ischemia, and during reperfusion. No difference was seen at baseline for conduction velocity or dispersion of repolarization between groups. Conduction velocity decreased from 0.46 ± 0.02 m/sec to 0.23 ± 0.07 m/sec, and dispersion of repolarization increased from 30 ± 5 msecs to 57 ± 4 msecs in the control group at 15 mins of ischemia. Mild hypothermia attenuated both the ischemia-induced conduction velocity slowing (decreasing from 0.44 ± 0.02 m/sec to 0.35 ± 0.03 m/sec; p = .019) and the ischemia-induced increase in dispersion of repolarization (25 ± 3 msecs to 37 ± 7 msecs; p = .037). Epicardial conduction block was observed in six of seven preparations of the control group, but no preparations in the mild hypothermia group developed conduction block (0/6). CONCLUSIONS:Mild hypothermia attenuated ischemia-induced increase in dispersion of repolarization, conduction slowing, and block, which are known mechanisms of arrhythmogenesis in ischemia. These data suggest that therapeutic hypothermia may decrease arrhythmogenesis during myocardial ischemia.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Piktel JS,Rosenbaum DS,Wilson LD

doi

10.1097/CCM.0b013e31825fd39d

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

2954-9

issue

11

eissn

0090-3493

issn

1530-0293

journal_volume

40

pub_type

杂志文章
  • Open lung ventilation preserves the response to delayed surfactant treatment in surfactant-deficient newborn piglets.

    abstract:OBJECTIVE:Delayed surfactant treatment (>2 hrs after birth) is less effective than early treatment in conventionally ventilated preterm infants with respiratory distress syndrome. The objective of this study was to evaluate if this time-dependent efficacy of surfactant treatment is also present during open lung ventila...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000243794.09377.96

    authors: van Veenendaal MB,van Kaam AH,Haitsma JJ,Lutter R,Lachmann B

    更新日期:2006-11-01 00:00:00

  • Application of a Framework to Assess the Usefulness of Alternative Sepsis Criteria.

    abstract::The current definition of sepsis is life-threatening, acute organ dysfunction secondary to a dysregulated host response to infection. Criteria to operationalize this definition can be judged by six domains of usefulness (reliability, content, construct and criterion validity, measurement burden, and timeliness). The r...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001724

    authors: Seymour CW,Coopersmith CM,Deutschman CS,Gesten F,Klompas M,Levy M,Martin GS,Osborn TM,Rhee C,Warren DK,Watson RS,Angus DC

    更新日期:2016-03-01 00:00:00

  • Renal function in critically ill postoperative patients: sequential assessment of creatinine osmolar and free water clearance.

    abstract::Sequential assessment of renal function in 50 critically ill postoperative patients was done by simultaneous determinants of osmolar, free water, creatinine and sodium clearances, and fractional excretion of sodium. The traumatic and nontraumatic critically ill surgical patients had a characteristic pattern of creatin...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198002000-00004

    authors: Brown R,Babcock R,Talbert J,Gruenberg J,Czurak C,Campbell M

    更新日期:1980-02-01 00:00:00

  • Characteristics and Outcomes of HIV-Infected Patients With Severe Sepsis: Continued Risk in the Post-Highly Active Antiretroviral Therapy Era.

    abstract:OBJECTIVES:Although highly active antiretroviral therapy has led to improved survival in HIV-infected individuals, outcomes for HIV-infected patients with sepsis in the post-highly active antiretroviral therapy era are conflicting. Access to highly active antiretroviral therapy and healthcare disparities continue to af...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001003

    authors: Cribbs SK,Tse C,Andrews J,Shenvi N,Martin GS

    更新日期:2015-08-01 00:00:00

  • Intensive care unit morbidity and mortality from eclampsia: an evaluation of the Acute Physiology and Chronic Health Evaluation II score and the Glasgow Coma Scale score.

    abstract:OBJECTIVE:To determine the maternal morbidity and mortality in patients with eclampsia admitted to an intensive care unit (ICU), and to establish the efficacy of the Acute Physiology and Chronic Health Evaluation (APACHE) II score, the organ system failure score as defined by Knaus, and the Glasgow Coma Scale (GCS) sco...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200001000-00020

    authors: Bhagwanjee S,Paruk F,Moodley J,Muckart DJ

    更新日期:2000-01-01 00:00:00

  • A quantitative assessment of how Canadian intensivists believe they utilize oxygen in the intensive care unit.

    abstract:OBJECTIVES:To investigate attitudes and practices regarding oxygen therapy in intensive care units (ICUs) and to devise quantitative descriptive indices. SETTING:Canadian university-affiliated adult ICUs. PARTICIPANTS:Fifty-two medical directors of ICUs in 48 institutions. INTERVENTION:Structured postal questionnair...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199912000-00033

    authors: Mao C,Wong DT,Slutsky AS,Kavanagh BP

    更新日期:1999-12-01 00:00:00

  • Role of protein kinase C and phosphatases in the pulmonary vasculature of neonatal piglets.

    abstract:OBJECTIVE:Persistent pulmonary hypertension of the newborn is characterized by the presence of intense vasoconstriction and vascular remodeling. Protein tyrosine phosphorylation has been recognized as a critical regulatory element in signal transduction, because it is dynamically regulated by the opposing actions of pr...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003246-200106000-00030

    authors: Berkenbosch JW,Baribeau J,Ferretti E,Perreault T

    更新日期:2001-06-01 00:00:00

  • Changes in the brain monoamine metabolism in acute liver failure produced by ischemia-reperfusion injury in rats.

    abstract:OBJECTIVE:To investigate the relationship between behavioral alterations and changes in monoaminergic systems provoked by ischemia-reperfusion liver injury in rats. DESIGN:Prospective, randomized, controlled animal study. SETTING:University animal laboratory. SUBJECTS:Male Wistar rats. INTERVENTIONS:Acute liver fai...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199804000-00021

    authors: Adachi N,Inoue H,Arai T

    更新日期:1998-04-01 00:00:00

  • Effect of pretreatment with interleukin-1 beta on inflammatory infiltrates and tissue damage after experimental endotoxic challenge.

    abstract:OBJECTIVE:To evaluate the effect of treatment with murine recombinant interleukin-1 beta on inflammatory infiltrate and tissue damage after experimental endotoxic challenge. DESIGN:Randomized, controlled study. SETTING:Experimental Unit, Virgen de las Nieves University Hospital. SUBJECTS:Seventy-two female CBA/H mic...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200208000-00025

    authors: Téllez-Gil L,Mansilla-Roselló A,Collado-Torres A,Villar-del-Moral J,Garrote-Lara D,Villegas-Herrera T,Alvarez-Martín MJ,Ferrón-Orihuela JA

    更新日期:2002-08-01 00:00:00

  • Impact of a pediatric clinical pharmacist in the pediatric intensive care unit.

    abstract:OBJECTIVE:To study the impact of a clinical pharmacist in a pediatric intensive care unit. The goals of the study were to determine the type and quantity of patient care interventions recommended by a clinical pharmacist and to specifically examine cost savings (or loss) that resulted from clinical pharmacist recommend...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200204000-00035

    authors: Krupicka MI,Bratton SL,Sonnenthal K,Goldstein B

    更新日期:2002-04-01 00:00:00

  • Adrenal insufficiency during the late stage of polymicrobial sepsis.

    abstract:OBJECTIVES:Although studies have indicated that adrenal insufficiency occurs after severe trauma and hemorrhagic shock, it remains controversial whether adrenal function is depressed during the late stage of polymicrobial sepsis. DESIGN:Prospective, controlled animal study. SETTING:A university research laboratory. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200103000-00026

    authors: Koo DJ,Jackman D,Chaudry IH,Wang P

    更新日期:2001-03-01 00:00:00

  • Private attending physician status and the withdrawal of life-sustaining interventions in a medical intensive care unit population.

    abstract:OBJECTIVE:To assess the influence of private attending physician status on the withdrawal of life-sustaining interventions among patients dying within a medical intensive care unit (ICU). DESIGN:Retrospective cohort analysis. SETTING:An academic tertiary care center. PATIENTS:One hundred fifty-nine consecutive patie...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199606000-00016

    authors: Kollef MH

    更新日期:1996-06-01 00:00:00

  • Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery.

    abstract:OBJECTIVE:Acute renal failure can be treated with continuous renal replacement therapy (CRRT) or intermittent hemodialysis. There is no difference in mortality, although patients treated with CRRT may have a higher rate of renal recovery. Given these considerations, an estimate of the costs by modality may help in choo...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000045182.90302.B3

    authors: Manns B,Doig CJ,Lee H,Dean S,Tonelli M,Johnson D,Donaldson C

    更新日期:2003-02-01 00:00:00

  • Critical Care Bed Capacity in Asian Countries and Regions.

    abstract:OBJECTIVE:To assess the number of adult critical care beds in Asian countries and regions in relation to population size. DESIGN:Cross-sectional observational study. SETTING:Twenty-three Asian countries and regions, covering 92.1% of the continent's population. PARTICIPANTS:Ten low-income and lower-middle-income eco...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004222

    authors: Phua J,Faruq MO,Kulkarni AP,Redjeki IS,Detleuxay K,Mendsaikhan N,Sann KK,Shrestha BR,Hashmi M,Palo JEM,Haniffa R,Wang C,Hashemian SMR,Konkayev A,Mat Nor MB,Patjanasoontorn B,Nafees KMK,Ling L,Nishimura M,Al Bahrani

    更新日期:2020-05-01 00:00:00

  • Intermittent mandatory ventilation in the neonate.

    abstract::Intermittent Mandatory Ventilation (IMV) provides an alternative method of support to assisted and controlled mechanical ventilation in neonates with acute respiratory failure. Specific advantages include the use of only the level of mechanical support which is required on an individual basis. Because intrapleural pre...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197701000-00004

    authors: Kirby RR

    更新日期:1977-01-01 00:00:00

  • Effect of full-time, specialized physician supervision on the success of a large, urban emergency medical services system.

    abstract:OBJECTIVES:Despite the universal proliferation of emergency medical services programs throughout the United States since 1970, only a few have ever documented a valid lifesaving effect, particularly in large, urban centers. The purpose of this study was to demonstrate the effect of specialized physician supervision on ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199309000-00009

    authors: Pepe PE,Mattox KL,Duke JH,Fisher PB,Prentice FD

    更新日期:1993-09-01 00:00:00

  • Features of Adult Hyperammonemia Not Due to Liver Failure in the ICU.

    abstract:OBJECTIVES:To evaluate the epidemiology of hyperammonemia unrelated to liver failure in the critical care setting. DESIGN:Retrospective case series. SETTING:Critically ill patients admitted to ICUs at Mayo Clinic, Rochester, MN (medical ICU, two mixed medical-surgical ICUs, coronary care unit, or the cardiosurgical I...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003278

    authors: Sakusic A,Sabov M,McCambridge AJ,Rabinstein AA,Singh TD,Mukesh K,Kashani KB,Cook D,Gajic O

    更新日期:2018-09-01 00:00:00

  • Noninvasive positive-pressure ventilation in acute respiratory failure outside clinical trials: experience at the Massachusetts General Hospital.

    abstract:BACKGROUND:Noninvasive positive-pressure ventilation (NPPV) has been shown to be effective in select patients enrolled in clinical trials. However, few data are available on the use of NPPV as routine standard medical care for patients with respiratory failure outside of controlled trials. MEASUREMENTS AND MAIN RESULT...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000300084.67277.90

    authors: Schettino G,Altobelli N,Kacmarek RM

    更新日期:2008-02-01 00:00:00

  • Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.

    abstract:OBJECTIVE:To determine the association of gender with the presentation, outcome, and host response in critically ill patients with sepsis. DESIGN AND SETTING:A prospective observational cohort study in the ICU of two tertiary hospitals between January 2011 and January 2014. PATIENTS:All consecutive critically ill pat...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000002649

    authors: van Vught LA,Scicluna BP,Wiewel MA,Hoogendijk AJ,Klein Klouwenberg PMC,Ong DSY,Cremer OL,Horn J,Franitza M,Toliat MR,Nürnberg P,Bonten MMJ,Schultz MJ,van der Poll T,MARS Consortium.

    更新日期:2017-11-01 00:00:00

  • The lectin-like domain of tumor necrosis factor improves lung function after rat lung transplantation--potential role for a reduction in reactive oxygen species generation.

    abstract:OBJECTIVE:To test the hypothesis that the lectin-like domain of tumor necrosis factor, mimicked by the TIP peptide, can improve lung function after unilateral orthotopic lung isotransplantation. Because of a lack of a specific treatment for ischemia reperfusion-mediated lung injury, accompanied by a disrupted barrier i...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181cdf725

    authors: Hamacher J,Stammberger U,Roux J,Kumar S,Yang G,Xiong C,Schmid RA,Fakin RM,Chakraborty T,Hossain HM,Pittet JF,Wendel A,Black SM,Lucas R

    更新日期:2010-03-01 00:00:00

  • Symptom experiences of family members of intensive care unit patients at high risk for dying.

    abstract:OBJECTIVE:To describe the symptom experiences of family members of patients at high risk for dying in the intensive care unit and to assess risk factors associated with higher symptom burden. DESIGN:Prospective, cross-sectional study. SETTING:Three intensive care units at a large academic medical center. PARTICIPANT...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0b013e3181cf6d94

    authors: McAdam JL,Dracup KA,White DB,Fontaine DK,Puntillo KA

    更新日期:2010-04-01 00:00:00

  • High permeability dialysis membrane allows effective removal of myoglobin in acute kidney injury resulting from rhabdomyolysis.

    abstract:OBJECTIVE:The objective of this study was to test the ability of myoglobin removal of a novel, high-permeability polysulphone dialyzer in acute kidney injury as a result of rhabdomyolysis. SETTING:Intensive care unit of a tertiary care hospital. PATIENTS:Six patients (one female; aged 24, 36, 41, 55, 63, and 65 yrs) ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181feb7f0

    authors: Sorrentino SA,Kielstein JT,Lukasz A,Sorrentino JN,Gohrbandt B,Haller H,Schmidt BM

    更新日期:2011-01-01 00:00:00

  • Death in the ICU: does the patient predict his own demise?

    abstract::Critically ill patients who fear impending death may die suddenly. We studied prospectively the incidence of death in critically ill surgical patients who articulated the fear that they were about to die. Physiologic, environmental, and behavioral correlates which might influence perceptions of impending death were ex...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198607000-00005

    authors: Poulton TJ,Butdorf MB

    更新日期:1986-07-01 00:00:00

  • Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans.

    abstract:OBJECTIVE:To define the impact of prehospital hypotension on the dynamic, systemic acute inflammatory response to blunt trauma. DESIGN:Retrospective study. SETTINGS:Tertiary care institution. PATIENTS:Twenty-two hypotensive blunt trauma patients matched with 28 normotensive blunt trauma patients. INTERVENTION:None....

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000964

    authors: Almahmoud K,Namas RA,Zaaqoq AM,Abdul-Malak O,Namas R,Zamora R,Sperry J,Billiar TR,Vodovotz Y

    更新日期:2015-07-01 00:00:00

  • Can we prevent the spread of focal lung inflammation?

    abstract::By definition, the acute respiratory distress syndrome is associated with diffuse cellular infiltration and proteinaceous edema. It is generally believed that the widespread injury that characterizes acute respiratory distress syndrome is a process that is launched almost synchronously throughout the lung, caused by b...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3181f20f01

    authors: Marini JJ

    更新日期:2010-10-01 00:00:00

  • N-acetylcysteine is effective for prevention but not for treatment of folic acid-induced acute kidney injury in mice.

    abstract:OBJECTIVES:There is controversy regarding the benefits of N-acetylcysteine in acute kidney injury. This study was to compare three commonly used regimens and explore which regimen is best for the protection of acute kidney injury. DESIGN:Prospective experimental study. SETTING:University research laboratory. INTERVE...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31822575fc

    authors: Wang HZ,Peng ZY,Wen XY,Rimmelé T,Bishop JV,Kellum JA

    更新日期:2011-11-01 00:00:00

  • Unmeasured anions in critically ill patients: can they predict mortality?

    abstract:OBJECTIVE:To determine whether base excess, base excess caused by unmeasured anions, and anion gap can predict lactate in adult critically ill patients, and also to determine whether acid-base variables can predict mortality in these patients. DESIGN:Retrospective study. SETTING:Adult intensive care unit of tertiary ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000079819.27515.8E

    authors: Rocktaeschel J,Morimatsu H,Uchino S,Bellomo R

    更新日期:2003-08-01 00:00:00

  • Intra-aortic balloon pump effects on macrocirculation and microcirculation in cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation*.

    abstract:OBJECTIVES:This study was designed to assess the effects on macrocirculation and microcirculation of adding an intra-aortic balloon pump to peripheral venoarterial extracorporeal membrane oxygenation in patients with severe cardiogenic shock and little/no residual left ventricular ejection. DESIGN:A prospective, singl...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000410

    authors: Petroni T,Harrois A,Amour J,Lebreton G,Brechot N,Tanaka S,Luyt CE,Trouillet JL,Chastre J,Leprince P,Duranteau J,Combes A

    更新日期:2014-09-01 00:00:00

  • Opioid receptors control viral replication in the airways.

    abstract:OBJECTIVE:Opioids are frequently used during mechanical ventilation for severe viral infection in infancy. Opioid receptors have immunomodulatory properties, but nothing is known about their antiviral effects. We therefore aimed to investigate the role of opioid receptors in virus-induced airway inflammation. PATIENTS...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31826767a8

    authors: Salimi V,Hennus MP,Mokhtari-Azad T,Shokri F,Janssen R,Hodemaekers HM,Rygiel TP,Coenjaerts FE,Meyaard L,Bont L

    更新日期:2013-01-01 00:00:00

  • Intensive Care Society's Acute Physiology and Chronic Health Evaluation (APACHE II) study in Britain and Ireland: a prospective, multicenter, cohort study comparing two methods for predicting outcome for adult intensive care patients.

    abstract:OBJECTIVE:To compare the ability of two methods--Acute Physiology and Chronic Health Evaluation (APACHE II) and Mortality Prediction Model (MPM)--to predict hospital outcome for a large group of intensive care patients from Britain and Ireland. DESIGN:Prospective, multicenter, cohort study. SETTING:Twenty-six general...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00003246-199409000-00007

    authors: Rowan KM,Kerr JH,Major E,McPherson K,Short A,Vessey MP

    更新日期:1994-09-01 00:00:00