Serum biomarkers in the diagnosis of periprosthetic joint infection: consolidated evidence and recent developments.

Abstract:

:Periprosthetic Joint Infection (PJI) represents one of the leading causes of revision prosthetic surgery, accounting for 25% of failed Total Knee Replacement (TKR) and 15% of failed Total Hip Replacement (THR). The search for a biomarker that, together with clinical and radiological findings, could improve the management of such a kind of patients is currently a big challenge for orthopaedic surgeons. This review aims (1) to assess the accuracy and the limitations of the traditional (Serum Erythrocytes Sedimentation Rate, C-reactive Protein, Procalcitonin, Interleukin 6, Tumor Necrosis Factor alpha), (2) and to analyse the emerging serum biomarkers (Presepsin, Toll-like Receptor 2, soluble urokinase-type Plasminogen Activator Receptor, Chemokine Ligand 2 and Osteopontin) in the diagnosis of PJI. A special attention will be given to the emerging serum biomarkers, that could play an important role as first-line investigations, in the screening of PJI in a close future.

authors

Vicenti G,Bizzoca D,Nappi V,Pesce V,Solarino G,Carrozzo M,Moretti F,Dicuonzo F,Moretti B

doi

10.26355/eurrev_201904_17473

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

43-50

issue

2 Suppl

eissn

1128-3602

issn

2284-0729

journal_volume

23

pub_type

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