Abstract:
BACKGROUND:Wernicke-Korsakoff syndrome (WKS) is a well described syndrome of neurological and cognitive problems that comprises both Wernicke's encephalopathy (WE) and Korsakoff syndrome (KS). WE is an acute neuropsychiatric disorder caused by thiamine deficiency. KS is a chronic consequence of thiamine deficiency with prominent impairment in memory formation. METHOD:The authors review the literature on the pathophysiology, presentation, and treatment of WKS, focusing on the acute identification and treatment of WE. RESULTS:Most cases of WE are missed by clinicians, likely because patients do not present with the classic signs associated with the condition. Attaining high serum levels of thiamine during treatment may be important to restore cognitive function as quickly as possible, though the exact dosing and route needed for effective treatment is unknown. Data indicates that the administration of intravenous (IV) thiamine has little risk. CONCLUSION:In order to prevent this potentially devastating disease, physicians should have a high index of suspicion for WKS and dose thiamine accordingly.
journal_name
Psychosomaticsjournal_title
Psychosomaticsauthors
Isenberg-Grzeda E,Kutner HE,Nicolson SEdoi
10.1016/j.psym.2012.04.008subject
Has Abstractpub_date
2012-11-01 00:00:00pages
507-16issue
6eissn
0033-3182issn
1545-7206pii
S0033-3182(12)00077-1journal_volume
53pub_type
杂志文章,评审相关文献
PSYCHOSOMATICS文献大全abstract::In a 12-week placebo-controlled study of fluoxetine in the treatment of body dysmorphic disorder, the authors investigated change in psychosocial functioning and mental health-related quality of life in 60 subjects. The subjects were assessed with the LIFE-RIFT (a measure of impaired functioning), Social and Occupatio...
journal_title:Psychosomatics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1176/appi.psy.45.5.438
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Falls and delirium in general-hospital inpatients are related to increases in morbidity, mortality, and healthcare costs. Patients fall despite safeguards and programs to reduce falling. OBJECTIVE:The authors sought to determine the prevalence of diagnosed and undiagnosed delirium in patients who fell durin...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.50.3.218
更新日期:2009-05-01 00:00:00
abstract::Authors evaluated the sensitivity and specificity of DSM-IV and ICD-10 criteria and the cutoff value of the Memorial Delirium Assessment Scale (MDAS) in diagnosing postoperative delirium in 260 cardiac surgery patients. Incidence of delirium diagnosed on the basis of DSM-IV and ICD-10 criteria, and with the use of the...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.49.1.73
更新日期:2008-01-01 00:00:00
abstract::Authors reviewed consecutive charts of 155 cognitive-disorder patients from a psychosomatic medicine service in 2001, analyzing factors of age, cognitive-disorder diagnosis, and length of stay. Mean length of stay for this cohort exceeded the typical hospital length of stay, and decreased with age. Increased age was a...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.47.5.414
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Even though viral management of HIV infection is now more effective, clinical observations suggest that fatigue remains a problem for a substantial proportion of patients. OBJECTIVE:The authors delineated prevalence and severity of fatigue in HIV patients with psychiatric comorbidities and examined psycholo...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.50.5.455
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Research has shown that Intensive Short-Term Dynamic Psychotherapy (ISTDP) can effectively decrease pain intensity and improve quality of life in patients with medically unexplained pain. OBJECTIVE:Understanding that not all patients with medically unexplained pain have access to in-person ISTDP, this study...
journal_title:Psychosomatics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psym.2016.01.001
更新日期:2016-05-01 00:00:00
abstract::The authors investigated long-term outcome and treatment strategy of corticosteroid-induced psychotic and mood disorders as defined by DSM-IV. Review of medical records of 2,069 referral patients revealed 18 applicable patients. Their clinical characteristics, longitudinal courses, and treatments were studied. The aut...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.42.6.461
更新日期:2001-11-01 00:00:00
abstract::Psychiatric admissions of patients infected with the human immunodeficiency virus (HIV) over a 5-year period (1986-1991) are reviewed. Ninety-one patients were studied. Suicidal thoughts/attempt was the most common reason for hospital admission. The two most common diagnostic categories were 1) organic mental syndrome...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/s0033-3182(94)71808-9
更新日期:1994-01-01 00:00:00
abstract::Adolescent cancer survivors were compared with nondiseased control subjects on measures of adaptation, coping, body image, sexual adjustment, psychopathology, and family functioning. Cancer survivors reported no major difficulties in social competence, overall coping, and family communication. Although their school te...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/S0033-3182(94)71739-4
更新日期:1994-09-01 00:00:00
abstract::Thirty inpatients with multiple somatoform symptoms admitted to a psychosomatic hospital were diagnosed using the Structured Clinical Interview for DSM-III-R and questionnaires. Two years later, a reexamination by interview and a follow-up questionnaire took place. The authors found high comorbidity rates not only for...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/S0033-3182(95)71647-4
更新日期:1995-07-01 00:00:00
abstract::This study identifies characteristics associated with problem substance use among 1,187 patients with either depressive symptoms (44%) or depressive disorders (56%) in primary care clinics of six managed care organizations. Sedative misuse (reported by 14% of all patients) was associated with greater wealth, social ph...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.43.5.405
更新日期:2002-09-01 00:00:00
abstract::In the treatment of psychiatric patients with complicating medical illness, clinicians may encounter patients who cannot take oral medications. This review will acquaint the practicing clinical psychiatrist with psychotropic medications available by nonenteral routes of administration. A computerized MEDLINE search wa...
journal_title:Psychosomatics
pub_type: 杂志文章,评审
doi:10.1016/S0033-3182(99)71234-X
更新日期:1999-05-01 00:00:00
abstract::The purpose of this study was to determine the utilization of medical specialists by anxiety disorder patients. The setting was a university's clinical outpatient drug trails for anxiety disorders. The participants were subjects identified by advertisement and diagnosed by psychiatric interviews and, in some instances...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/S0033-3182(97)71478-6
更新日期:1997-03-01 00:00:00
abstract::The authors examine the relationship of the Toronto Alexithymia Scale (TAS) to sociodemographic characteristics, medical history, symptomatology, and illness cognition in a sample of 244 family medicine patients. The TAS had moderate internal reliability. In multiple regression analysis, the TAS was related to age, ed...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/S0033-3182(93)71926-X
更新日期:1993-01-01 00:00:00
abstract::This study evaluated screening abilities of self-report questionnaires for depression in first myocardial infarction (MI) patients. One month post-MI, 206 patients with first MI were screened for major and minor depression using the 90-item Symptom Check List (SCL-90), the Beck Depression Inventory (BDI), the Hospital...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.42.5.423
更新日期:2001-09-01 00:00:00
abstract::Dizziness is a common patient symptom and often remains medically unexplained even after an extensive work-up. The otologic disorders, psychiatric disorders, and functional disability of 75 patients presenting with dizziness to a community otolaryngology practice were assessed in 1991. The patients were classified acc...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/S0033-3182(93)71844-7
更新日期:1993-09-01 00:00:00
abstract::Of 15 patients with fibromyalgia who were first evaluated for the presence of Axis I psychiatric diagnoses by use of the Structured Clinical Interview for DSM-IV, 11 completed an open 8-week trial with the novel antidepressant venlafaxine. Six (55%) of 11 completers experienced a > or = 50% reduction of fibromyalgia s...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/S0033-3182(98)71375-1
更新日期:1998-01-01 00:00:00
abstract::The impact of a community-based consultation-liaison (C-L) psychiatry service on family physicians' levels of psychiatric knowledge, diagnostic and treatment confidence, and patterns of referral to mental health care agencies was evaluated over a 12-month period. The physicians with long-term access to the C-L service...
journal_title:Psychosomatics
pub_type: 杂志文章,评审
doi:10.1016/S0033-3182(97)71458-0
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Delirium commonly occurs in hospitalized elderly patients, resulting in increased morbidity and mortality. Although evidence for treatment of delirium exists, evidence supporting pharmacologic prevention of delirium in high risk patients is limited. OBJECTIVE:This review examined whether delirium in at-risk...
journal_title:Psychosomatics
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.psym.2012.12.004
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Patients with severe psychiatric disorders such as schizophrenia and bipolar affective disorder (BPAD) have in the past been excluded from organ transplantation programs based on their psychiatric illness. However, there is little data on the outcomes of renal transplantation in these patients and little evi...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/j.psym.2016.08.010
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Physical activity is strongly associated with lower risk of recurrent cardiac events in patients who experience an acute coronary syndrome (ACS), yet most patients do not meet recommended levels of physical activity. Psychological well-being is associated with higher levels of physical activity, but midlife ...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/j.psym.2020.06.002
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:Although the hepatitis C virus (HCV) alone increases the risk of cirrhosis, alcohol use is thought to act synergistically with HCV to significantly hasten the development of fibrosis. OBJECTIVE:The authors assessed the impact of brief medical counseling or integrated-care approaches to lessen or eliminate a...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.51.2.149
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Delirium is a prevalent neuropsychiatric disorder associated with increased morbidity and mortality. Half the cases remain misdiagnosed. OBJECTIVE:Assess the effectiveness of the Stanford Proxy Test for Delirium (S-PTD) in detecting delirium in an inpatient setting. METHODS:This is a comparison study. Dail...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/j.psym.2019.11.009
更新日期:2020-01-01 00:00:00
abstract::A study was conducted on a group of chronically hospitalized, brain-damaged male patients to assess the effectiveness of treatment with pindolol on behavioral problems. The study was conducted in two parts. The first was a double-blind, placebo-controlled analysis of the effect of pindolol on assaultive behavior, both...
journal_title:Psychosomatics
pub_type: 临床试验,杂志文章
doi:10.1016/S0033-3182(89)72297-0
更新日期:1989-04-01 00:00:00
abstract::The purpose of this study was to identify the proximate causes through which dementia and delirium extend length of stay (LOS) in elderly general hospital patients. Among 93 patients age >/=65 years admitted to a tertiary-care teaching hospital through the emergency department, admission ratings of cognitive impairmen...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.45.3.235
更新日期:2004-05-01 00:00:00
abstract::Only a few published accounts describe atypical anorexia nervosa. To provide more information about this eating-disorder subtype, 15 patients (12 females, 3 males) with atypical anorexia nervosa were studied. In general, the 12 female patients were characterized by 1) older age at onset and presentation, 2) recurring ...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/S0033-3182(89)72277-5
更新日期:1989-07-01 00:00:00
abstract::In Part 1 of this 2-part series, the epidemiology of psychiatric disorders in primary care settings was reviewed as well as evidence that indicates that these conditions often go underrecognized and undertreated by primary care physicians. Educational studies to improve the psychiatric skills of primary care physician...
journal_title:Psychosomatics
pub_type: 杂志文章,评审
doi:10.1016/S0033-3182(97)71497-X
更新日期:1997-01-01 00:00:00
abstract::The psychological status and quality of life of 70 stable patients with asthma age > or =60 years and 40 age-matched comparison subjects were examined. The patients with long-standing asthma (duration > or = 8 years) had lower quality-of-life scores than those with recent-onset asthma (duration < 8 years). In multivar...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1176/appi.psy.46.1.41
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The implementation of emergency codes has become standard practice in hospitals to provide system-wide preparedness for the early detection and prevention of crises. Psychiatric emergencies in medical/surgical locations, however, are not typically regarded as distinct entities from general security threats. ...
journal_title:Psychosomatics
pub_type: 杂志文章,评审
doi:10.1016/j.psym.2019.03.006
更新日期:2019-01-01 00:00:00
abstract::As clinical ethicists increasingly populate hospital settings, a definition of their roles and responsibilities vis à vis those of consultation-liaison (C-L) psychiatrists remains a matter of both interest and uncertainty. Both fields share certain evolutionary and ideological features, yet until very recently, psychi...
journal_title:Psychosomatics
pub_type: 杂志文章
doi:10.1016/S0033-3182(97)71437-3
更新日期:1997-07-01 00:00:00