Selective inhibition of monoamine oxidase type B by MDL 72145 increases the central effects of L-dopa without modifying its cardiovascular effects.

abstract：:Prostate cancer is the second most common malignancy in men and androgen deprivation therapy is the first-line therapy. However, most cases will eventually develop castration-resistant prostate cancer after androgen deprivation therapy treatment. Enzalutamide is a second-generation androgen receptor antagonist approve...

journal_title：British journal of pharmacology

authors： Wang Y,Chen J,Wu Z,Ding W,Gao S,Gao Y,Xu C

更新日期：2020-11-05 00:00:00

abstract：:In the present study we tested the effects of the antihyperalgesic compound gabapentin on dorsal horn neurones in adult spinal cord. Slices were taken from control and hyperalgesic animals suffering from streptozocin-induced diabetic neuropathy. At concentrations up to 100 microM, bath application failed to affect the...

journal_title：British journal of pharmacology

authors： Patel MK,Gonzalez MI,Bramwell S,Pinnock RD,Lee K

更新日期：2000-08-01 00:00:00

abstract：:The effects of the alpha- and beta-isomers of flupenthixol on 5-hydroxytryptamine (5-HT)-induced platelet aggregation and on 5-HT and dopamine uptake were investigated. Alpha-Flupenthixol was 185 times more potent than the beta-isomer as an inhibitor of platelet aggregation. In contrast both isomers were equipotent a...

journal_title：British journal of pharmacology

authors： Boullin DJ,Grimes RP,Orr MW

更新日期：1975-12-01 00:00:00

abstract：:1. Human epicardial coronary artery rings, freshly obtained from cardiac transplant patients, were examined for their responses to endothelium-derived relaxing factor (EDRF)-releasing agents. 2. Functional antagonism profoundly influenced relaxation responses in this tissue. Increasing force with concentrations of U46...

journal_title：British journal of pharmacology

authors： Stork AP,Cocks TM

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sphingosine-1-phosphate (S1P) has been shown to be involved in the asthmatic disease as well in preclinical mouse experimental models of this disease. The aim of this study was to understand the mechanism(s) underlying S1P effects on the lung. EXPERIMENTAL APPROACH:BALB/c, mast cell-deficient an...

journal_title：British journal of pharmacology

authors： Roviezzo F,Sorrentino R,Bertolino A,De Gruttola L,Terlizzi M,Pinto A,Napolitano M,Castello G,D'Agostino B,Ianaro A,Sorrentino R,Cirino G

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cholecystokinin (CCK) is secreted by intestinal I cells and regulates important metabolic functions. In pancreatic islets, CCK controls beta cell functions primarily through CCK1 receptors, but the signalling pathways downstream of these receptors in pancreatic beta cells are not well defined. E...

journal_title：British journal of pharmacology

authors： Ning SL,Zheng WS,Su J,Liang N,Li H,Zhang DL,Liu CH,Dong JH,Zhang ZK,Cui M,Hu QX,Chen CC,Liu CH,Wang C,Pang Q,Chen YX,Yu X,Sun JP

更新日期：2015-11-01 00:00:00

abstract：:1 A newly synthesized substance P (SP) analogue, (D-Pro2, D-Trp7,9)-SP, specifically antagonizes the contractile effects of SP on the guinea-pig isolated taenia coli. In addition, previous studies had indicated that the SP analogue per se is capable of contracting this preparation. The results of the present study on ...

journal_title：British journal of pharmacology

authors： Håkanson R,Hörig J,Leander S

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We recently reported that AAV1-Rheb(S16H) transduction could protect hippocampal neurons through the induction of brain-derived neurotrophic factor (BDNF) in the rat hippocampus in vivo. It is still unclear how neuronal BDNF produced by AAV1-Rheb(S16H) transduction induces neuroprotective effects...

journal_title：British journal of pharmacology

authors： Jeon MT,Moon GJ,Kim S,Choi M,Oh YS,Kim DW,Kim HJ,Lee KJ,Choe Y,Ha CM,Jang IS,Nakamura M,McLean C,Chung WS,Shin WH,Lee SG,Kim SR

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Avoiding danger and finding food are closely related behaviours that are essential for surviving in a natural environment. Growing evidence supports an important role of gut-brain peptides in modulating energy homeostasis and emotional-affective behaviour. For instance, postprandial release of pa...

journal_title：British journal of pharmacology

authors： Verma D,Hörmer B,Bellmann-Sickert K,Thieme V,Beck-Sickinger AG,Herzog H,Sperk G,Tasan RO

更新日期：2016-06-01 00:00:00

abstract：:The effects of local perivascular application of dopamine to rat pial arterioles. (20-40 micrometer i.d.) were examined in situ, at the microcirculatory level, by use of a high-resolution closed circuit television microscope recording system. Local application of very low, physiological doses (1 to 10 pg) of dopamine ...

journal_title：British journal of pharmacology

authors： Altura BM,Gebrewold A,Lassoff S

更新日期：1980-08-01 00:00:00

abstract：:The selective monoamine oxidase (MAO) inhibitors clorgyline, selegiline and AGN 1135 did not cause a change in responses of the cat nictitating membrane to preganglionic sympathetic nerve stimulation at 5 Hz. Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response t...

journal_title：British journal of pharmacology

authors： Finberg JP,Youdim MB

更新日期：1985-06-01 00:00:00

abstract：LINKED ARTICLES:This article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc. ...

journal_title：British journal of pharmacology

authors： Stanford SC

更新日期：2018-08-01 00:00:00

abstract：:Following the discovery of the involvement of the ribonucleoprotein TDP-43 in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), a major research focus has been to develop treatments that can prevent or alleviate these disease conditions. One pharmacological approach has been to use TDP-...

journal_title：British journal of pharmacology

authors： Buratti E

更新日期：2020-05-29 00:00:00

abstract：:The diterpene, forskolin, is shown to produce a concentration-dependent, increase in short circuit current in two epithelial preparations, amphibian skin and rat colon. In the amphibian tissue the increase is sensitive to amiloride and due to an increase in electrogenic transepithelial sodium transport towards the ser...

journal_title：British journal of pharmacology

authors： Cuthbert AW,Spayne JA

更新日期：1982-05-01 00:00:00

abstract：:1. The effects of melanotrophin release inhibiting factor (MIF) and its cyclic analogue cyclo (Leu-Gly) on tolerance to the analgesic effect of morphine were studied in male Sprague-Dawley rats. 2. Tolerance to morphine was induced by implantation of four morphine pellets (each containing 75 mg of morphine free base) ...

journal_title：British journal of pharmacology

authors： Bhargava HN

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Here, we have compared the neurochemical profile of three new cathinones, butylone, mephedrone and methylone, in terms of their potential to inhibit plasmalemmal and vesicular monoamine transporters. Their interaction with 5-HT and dopamine receptors and their psychostimulant effect was also stud...

journal_title：British journal of pharmacology

authors： López-Arnau R,Martínez-Clemente J,Pubill D,Escubedo E,Camarasa J

更新日期：2012-09-01 00:00:00

abstract：:1. The ionic dependence of [(3)H]-metaraminol transport by rabbit ventricular slices was studied.2. Transport was Na(+) dependent. Choline, Li(+), K(+), Rb(+) or Cs(+) could not be substituted for Na(+).3. Transport was K(+) dependent. Rb(+) and Cs(+), but not Li, could be substituted for K(+), their relative potencie...

journal_title：British journal of pharmacology

authors： Paton DM

更新日期：1971-01-01 00:00:00

abstract：:1 The selectivity and specificity of RX 781094 [2-(2-(1,4 benzodioxanyl))2-imidazoline HCl] for alpha-adrenoceptors have been examined in peripheral tissues. 2 In isolated tissue experiments RX 781094 was a competitive antagonist at prejunctional alpha 2-adrenoceptors situated on the sympathetic nerve terminals of the...

journal_title：British journal of pharmacology

authors： Doxey JC,Roach AG,Smith CF

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Avarol is a marine sesquiterpenoid hydroquinone with anti-inflammatory and antipsoriatic properties. The aim of this study was to evaluate the in vitro and in vivo pharmacological behaviour of the derivative avarol-3'-thiosalicylate (TA) on some inflammatory parameters related to the pathogenesis...

journal_title：British journal of pharmacology

authors： Amigó M,Payá M,De Rosa S,Terencio MC

更新日期：2007-10-01 00:00:00

abstract：:1. In a rat model of experimental ileus, the effect of blockade of adrenergic and nitrergic neurotransmission was studied on the intestinal transit of Evans blue. 2. Ether anaesthesia and skin incision had no influence on the transit. Laparotomy significantly inhibited the transit of Evans blue. This inhibition was ev...

journal_title：British journal of pharmacology

authors： De Winter BY,Boeckxstaens GE,De Man JG,Moreels TG,Herman AG,Pelckmans PA

更新日期：1997-02-01 00:00:00

abstract：:1. Human mast cell tryptase appears to display considerable variation in activating proteinase-activated receptor 2 (PAR(2)). We found tryptase to be an inefficient activator of wild-type rat-PAR(2) (wt-rPAR(2)) and therefore decided to explore the factors that may influence tryptase activation of PAR(2). 2. Using a 2...

journal_title：British journal of pharmacology

authors： Compton SJ,Renaux B,Wijesuriya SJ,Hollenberg MD

更新日期：2001-10-01 00:00:00

abstract：:1 Vasodilator responses to histamine, bradykinin and sympathetic nerve stimulation were elicited in the perfused paw of dogs treated with bretylium (15-20 mg/kg) and atropine. The H2-receptor blocking agent, burimamide, when administered in the dose of 5 mg/kg intravenously and 4 mg intra-arterially did not depress si...

journal_title：British journal of pharmacology

authors： Kraft E,Zimmerman BG

更新日期：1975-01-01 00:00:00

abstract：:1. Vasoconstrictions induced by transmural electrical field stimulation were frequency-dependent from 2 to 32 Hz in the rabbit isolated splenic artery. All contractions were abolished in the presence of tetrodotoxin 1 microM or guanethidine 100 microM. Stimulation at a frequency of more than 32 Hz induced both neuroge...

journal_title：British journal of pharmacology

authors： Ren LM,Burnstock G

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT). Here we report the generation of a mouse line that expresses MB-COMT but not S-COMT. We compared the effects of deleting S-COMT only or both C...

journal_title：British journal of pharmacology

authors： Käenmäki M,Tammimäki A,Garcia-Horsman JA,Myöhänen T,Schendzielorz N,Karayiorgou M,Gogos JA,Männistö PT

更新日期：2009-12-01 00:00:00

abstract：:1 A procedure involving two guinea-pig isolated hearts perfused in series is described for detecting in the recipient heart the release of a possible coronary vasodilator metabolite from the donor heart. 2 Adrenaline and isoprenaline stimulated the rate and force of contraction and produced a multiphasic coronary vasc...

journal_title：British journal of pharmacology

authors： Broadley KJ

更新日期：1976-09-01 00:00:00

abstract：:1. The effects of inhibiting endogenous Cu/Zn superoxide dismutase (SOD) with diethyldithiocarbamate (DETCA) were examined on the ability of hydroquinone, hydroxocobalamin and carboxy-PTIO to block nitrergic relaxation in the bovine retractor penis (BRP) muscle. 2. Incubation of strips of BRP with DETCA (3 mM) for 2 h...

journal_title：British journal of pharmacology

authors： Paisley K,Martin W

更新日期：1996-04-01 00:00:00

abstract：:1. It has been suggested that the vasoconstrictor response to neuropeptide Y (NPY) is located in the microvessels and that it increases with reduced vessel diameter. The aim of the present study was to analyse quantitatively, on the cat gastrocnemius muscle preparation in vivo, the effects of NPY on total regional vas...

journal_title：British journal of pharmacology

authors： Ekelund U,Erlinge D

更新日期：1997-02-01 00:00:00

abstract：:1. The central and peripheral effects of the omega (benzodiazepine) site ligands, clonazepam, alpidem, zolpidem, triazolam, flumazenil, ethyl beta carboline-3-carboxylate (beta-CCE) and N-methyl beta carboline-3-carboxylate (beta-CCM) on intestinal myoelectrical activity were evaluated in conscious rats, chronically f...

journal_title：British journal of pharmacology

authors： Bonnafous C,Scatton B,Buéno L

更新日期：1994-09-01 00:00:00

abstract：:1. In the present study we have characterized the parathyroid hormone (PTH)-induced calcium signalling in 293 cells stably transfected with the human PTH receptor cDNA. In these cells, human PTH-1(1-38) strongly stimulates adenosine 3':5'-cyclic monophosphate (cyclic AMP) formation (EC50 = 0.39 nM) but fails to activa...

journal_title：British journal of pharmacology

authors： Seuwen K,Boddeke HG

更新日期：1995-04-01 00:00:00

abstract：:A dispersed rat anterior pituitary cell system has been used to investigate the effects of cyproheptadine and metergoline on prolactin secretion. Both drugs were potent inhibitors of prolactin secretion. However, the inhibition was not antagonized by either 5-hydroxytryptamine or a variety of dopamine antagonists. We ...

journal_title：British journal of pharmacology

authors： Besser GM,Delitala G,Grossman A,Yeo T

更新日期：1980-09-01 00:00:00