Immune cells in peripheral lymph and skin of patients with obstructive lymphedema.

Abstract:

:Lymph stasis in the extremities caused by interruption of lymphatics or insufficient lymph propulsion is often complicated by recurrent skin infections. To shed further light on this subject, we studied the phenotypical and functional characteristics of cells in peripheral lymph and skin of patients with obstructive lymphedema. Compared with controls, patients with secondary lymphedema displayed a high concentration of lymphocytes and erythrocytes in peripheral lymph, sometimes increased numbers of B cells, increased density of Langerhans cells in the epidermis and occasionally in the skin papillary layer, strong expression of class II antigens on skin endothelial cells and mononuclear infiltration around blood vessels, and margination of granulocytes in skin blood vessels. Reactivity of lymph cells to mitogens was augmented. Taken together these findings indicate that ongoing chronic inflammatory processes persist in skin with lymph stasis, and, moreover, with impaired lymphocyte and Langerhans cell trafficking from skin to regional lymph nodes and inefficient clearance of foreign antigens, these lymphedematous limbs become susceptible to infection.

journal_name

Lymphology

journal_title

Lymphology

authors

Olszewski WL,Engeset A,Romaniuk A,Grzelak I,Ziolkowska A

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

23-33

issue

1

eissn

0024-7766

issn

2522-7963

journal_volume

23

pub_type

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