Abstract:
:Thrombopoietin (TPO) regulates thrombopoiesis through activation of TPO receptors on the megakaryocyte cell surface, resulting in increased platelet production. The TPO receptor agonists are novel treatments for patients with chronic ITP aimed at increasing platelet production through interactions with the TPO receptor on megakaryocytes. Two TPO receptor agonists, romiplostim and eltrombopag, have received regulatory approval. In patients with chronic ITP who remain at risk of bleeding following treatment with first-line therapies, these agents have been shown to increase platelet counts, decrease bleeding events, and reduce the need for adjunctive or rescue treatments. The TPO receptor agonists are well-tolerated, though uncertainty remains regarding the risk of thromboembolism and bone marrow fibrosis. Comparative clinical trial data addressing the efficacy, safety, cost-effectiveness, and impact on health-related quality of life of TPO receptor agonists relative to other second-line treatment options are needed to guide treatment decisions in chronic ITP patients who fail first-line therapies.
journal_name
Semin Hematoljournal_title
Seminars in hematologyauthors
Siegal D,Crowther M,Cuker Adoi
10.1053/j.seminhematol.2013.03.005subject
Has Abstractpub_date
2013-01-01 00:00:00pages
S18-21eissn
0037-1963issn
1532-8686pii
S0037-1963(13)00024-3journal_volume
50 Suppl 1pub_type
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
pub_type: 杂志文章,评审
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journal_title:Seminars in hematology
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journal_title:Seminars in hematology
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