Biology of chronic lymphocytic leukemia.

Abstract:

:Chronic lymphocytic leukemia (CLL) is a clonal proliferation of mature-appearing, but maturationally immature B cells; T cells are rarely involved. Most data suggest that CLL cells are frozen at an early step in maturation; this can be overcome by several techniques such as in vitro incubation with tumor promotors. Although B-CLL involves B cells, and abnormal T cell function is common, its etiology is uncertain. Oncogene abnormalities and retroviral infection have been reported in rare cases of CLL; their role in more typical cases is unknown.

journal_name

Semin Hematol

journal_title

Seminars in hematology

authors

Gale RP,Foon KA

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

209-29

issue

4

eissn

0037-1963

issn

1532-8686

journal_volume

24

pub_type

杂志文章,评审
  • Congenital Defects in the Expression of the Glycosylphosphatidylinositol-Anchored Complement Regulatory Proteins CD59 and Decay-Accelerating Factor.

    abstract::CD59 and decay-accelerating factor (DAF) are glycosylphosphatidylinositol (GPI)-anchored complement regulatory proteins critical for regulating complement activation on the host cell surface. Defective expressions of CD59 or DAF caused by mutations in the genes coding for these proteins or genes involved in the biosyn...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2018.04.004

    authors: Kinoshita T

    更新日期:2018-07-01 00:00:00

  • The effect of recombinant human colony-stimulating factors on hematopoietic reconstitution following autologous bone marrow transplantation.

    abstract::The prolonged and severe myelosuppression associated with high-dose chemotherapy and autologous bone marrow transplantation is a major causative factor in patient morbidity and mortality resulting from infection and other causes. The recent molecular cloning, in vitro expression, and formulation of recombinant human c...

    journal_title:Seminars in hematology

    pub_type: 杂志文章

    doi:

    authors: Peters WP

    更新日期:1989-04-01 00:00:00

  • Reducing mortality associated with immediate treatment complications of adult leukemias.

    abstract::Analysis of data from 806 patients with newly diagnosed adult acute myelocytic leukemia (AML) (not including acute promyelocytic leukemia [APL] patients) treated at M.D. Anderson Cancer Center from 1995 through 1999 indicated that among patients entering a particular week of induction therapy, mortality rates were 6%,...

    journal_title:Seminars in hematology

    pub_type: 杂志文章

    doi:10.1016/s0037-1963(01)90042-3

    authors: Estey E

    更新日期:2001-10-01 00:00:00

  • Further understanding of recombinant activated factor VII mode of action.

    abstract::Recombinant activated factor VII (rFVIIa) is being increasingly used to treat bleeding associated with a variety of non-hemophilic coagulopathic indications, and its mechanism of action in these areas is under active investigation. Numerous studies have shown that FVIIa binds with low affinity to activated platelets; ...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2008.03.013

    authors: Monroe DM

    更新日期:2008-04-01 00:00:00

  • Idiopathic thrombocytopenia purpura: Treatment patterns and an analysis of cost associated with intravenous immunoglobulin and anti-D therapy.

    abstract::A retrospective study was conducted to determine treatment patterns for idiopathic thrombocytopenia purpura (ITP) across the US and to determine the cost of its treatment with high-dose intravenous immunoglobulin (IVIg) and anti-D therapy. Information on the incidence, treatment patterns, hospital care, and costs for ...

    journal_title:Seminars in hematology

    pub_type: 杂志文章

    doi:

    authors: Simpson KN,Coughlin CM,Eron J,Bussel JB

    更新日期:1998-01-01 00:00:00

  • Platelets in thrombotic disorders: quantitative and qualitative platelet disorders predisposing to arterial thrombosis.

    abstract::Endogenous thrombopoietin (TPO) stimulates platelet production in nonhuman primates by inducing dose-dependent megakaryocyte development from early marrow hematopoietic progenitors and subsequent proliferation and endoreduplication. In nonhuman primates, recombinant human TPO, nonpegylated or pegylated rHu megakaryocy...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:

    authors: Harker LA

    更新日期:1998-07-01 00:00:00

  • Myelodysplastic syndromes: From pathogenesis and prognosis to treatment.

    abstract::Myelodysplastic syndromes (MDS) are clonal hematologic disorders characterized by ineffective hematopoiesis resulting in peripheral cytopenia and by increased progression to acute myelocytic leukemia (AML). With the exception of allogeneic stem cell transplantation, there is generally no curative treatment for these d...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2004.02.002

    authors: Fenaux P

    更新日期:2004-04-01 00:00:00

  • Proteasome inhibition for antibody-mediated allograft rejection.

    abstract::Antibody-mediated rejection (AMR) is a major risk factor for graft loss following kidney transplantation. Traditional anti-humoral therapies provide suboptimal therapy and they do not deplete plasma cells, which are the source of antibody production. Proteasome inhibitors (PI) have been shown to deplete both transform...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2012.04.008

    authors: Sadaka B,Alloway RR,Shields AR,Schmidt NM,Woodle ES

    更新日期:2012-07-01 00:00:00

  • Pharmacokinetics of all-trans-retinoic acid: clinical implications in acute promyelocytic leukemia.

    abstract::Continuous daily treatment with all-trans-retinoic acid (ATRA) in patients with acute promyelocytic leukemia has been associated with a marked decline in the plasma drug concentration at the time of relapse. Recent pharmacologic studies have attempted to determine the reasons for the progressive reduction of plasma co...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:

    authors: Adamson PC

    更新日期:1994-10-01 00:00:00

  • Assessment of treatment strategy in high-risk surgical patients.

    abstract::The risk of postoperative venous thromboembolism (VTE) is dependent on the type of surgical procedure and specific characteristics of the patient. Patients with intrinsic factors placing them at higher risk of VTE remain at high risk, even if the procedural risk is low. The identification of factors such as age, obesi...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1016/s0037-1963(00)90094-5

    authors: Samama MM

    更新日期:2000-07-01 00:00:00

  • Novel agents in development for peripheral T-cell lymphoma.

    abstract::Though peripheral T-cell lymphoma (PTCL) is an area of significant unmet therapeutic need, a number of new treatment options are available for patients, especially those with relapsed or refractory disease. A plethora of drugs are now in development for PTCL, but drugs that truly target novel disease biology are notic...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2010.01.014

    authors: O'Connor OA

    更新日期:2010-04-01 00:00:00

  • TET-dioxygenase deficiency in oncogenesis and its targeting for tumor-selective therapeutics.

    abstract::TET2 is one of the most frequently mutated genes in myeloid neoplasms. TET2 loss-of-function perturbs myeloid differentiation and causes clonal expansion. Despite extensive knowledge regarding biochemical mechanisms underlying distorted myeloid differentiation, targeted therapies are lagging. Here we review known bioc...

    journal_title:Seminars in hematology

    pub_type: 杂志文章

    doi:10.1053/j.seminhematol.2020.12.002

    authors: Guan Y,Hasipek M,Tiwari AD,Maciejewski JP,Jha BK

    更新日期:2021-01-01 00:00:00

  • The potential role of new therapies in deep-vein thrombosis prophylaxis.

    abstract::The value of prophylaxis against venous thromboembolism (VTE) is increasingly accepted in most surgical specialties, although the potential reduction in fatal pulmonary embolism has recently been questioned. The burden of VTE in hospital patients nevertheless remains high, partly attributable to underuse of thrombopro...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/shem.2001.25188

    authors: Wille-Jørgensen P

    更新日期:2001-04-01 00:00:00

  • Neonatal thrombocytopenia and megakaryocytopoiesis.

    abstract::Thrombocytopenia is common among sick neonates, affecting 20% to 35% of all patients admitted to the neonatal intensive care unit (NICU). While most cases of neonatal thrombocytopenia are mild or moderate and resolve within 7 to 14 days with appropriate therapy, 2.5% to 5% of NICU patients develop severe thrombocytope...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2010.04.002

    authors: Ferrer-Marin F,Liu ZJ,Gutti R,Sola-Visner M

    更新日期:2010-07-01 00:00:00

  • Myelodysplastic syndromes.

    abstract::These two issues of the Seminars in Hematology will provide the physician the necessary knowledge to help make sense of this somewhat confusing array of diseases. The subdivisions of MDS reflect the precision of our techniques of dissection, with morphological and histochemical analyses forming the foundation to ident...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:

    authors: Koeffler HP

    更新日期:1996-04-01 00:00:00

  • Surface and cytoskeletal events regulating leukocyte membrane topography.

    abstract::The experiments reviewed here establish that surface components and surface functions can assume predictable, asymmetric patterns within the continuous plasma membranes of mammalian leukocytes. Recent biophysical and morphological studies show that receptor redistribution can occur very rapidly and that a unique geome...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:

    authors: Oliver JM,Berlin RD

    更新日期:1983-10-01 00:00:00

  • Relapsed/Refractory multiple myeloma: defining refractory disease and identifying strategies to overcome resistance.

    abstract::Despite the development of more effective therapies for multiple myeloma (MM) over the past decade, nearly all patients will eventually experience disease relapse and require further therapy. Designing the next generation of therapies for relapsed and refractory disease will depend on understanding the complex molecul...

    journal_title:Seminars in hematology

    pub_type: 杂志文章

    doi:10.1053/j.seminhematol.2012.05.005

    authors: Siegel DS

    更新日期:2012-07-01 00:00:00

  • Structural and functional characterization of B-domain deleted recombinant factor VIII.

    abstract::A new high-purity recombinant factor VIII preparation has been developed for the treatment of hemophilia A. Structurally, this factor VIII preparation, B-domain deleted recombinant factor VIII (BDDrFVIII), differs from other recombinant and plasma-derived factor VIII preparations in that most of the B-domain has been ...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1016/s0037-1963(01)90103-9

    authors: Sandberg H,Almstedt A,Brandt J,Castro VM,Gray E,Holmquist L,Lewin M,Oswaldsson U,Mikaelsson M,Jankowski MA,Bond M,Scoble HA

    更新日期:2001-04-01 00:00:00

  • Molecular evaluation of acute myeloid leukemias.

    abstract::Traditionally, acute myeloid leukemia (AML) has been diagnosed and classified based on the morphologic and cytochemical criteria of the French-American-British (FAB) classification system. However, more recent studies have demonstrated that the cytogenetic and molecular genetic abnormalities consistently associated wi...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:

    authors: Willman CL

    更新日期:1999-10-01 00:00:00

  • Survival signals in leukemic large granular lymphocytes.

    abstract::The central hypothesis of our laboratory research program in large granular lymphocyte (LGL) leukemia is that leukemic LGL represent antigen-driven cytotoxic T lymphocytes (CTL) with characteristics of dysregulated apoptosis. The clinical features of LGL leukemia highlight the association of autoimmune diseases such a...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1016/s0037-1963(03)00135-5

    authors: Epling-Burnette PK,Loughran TP Jr

    更新日期:2003-07-01 00:00:00

  • Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia.

    abstract::Comprehensive study of the major chromosomal/molecular abnormalities in children and adults with acute lymphoblastic leukemia (ALL) has demonstrated prognostic utility for many of these anomalies, to the extent that cytogenetic and molecular genetic evaluations are now required for optimal clinical management of newly...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1016/s0037-1963(00)90018-0

    authors: Ferrando AA,Look AT

    更新日期:2000-10-01 00:00:00

  • Resistance to imatinib: mutations and beyond.

    abstract::Mechanisms of resistance to the tyrosine kinase inhibitor (TKI) imatinib had been modeled in vitro even prior to the first reports of clinical resistance in patients with chronic myeloid leukemia (CML). The discovery that BCR-ABL is reactivated at the time of resistance and the unveiling of point mutations within the ...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2010.06.005

    authors: La Rosée P,Deininger MW

    更新日期:2010-10-01 00:00:00

  • Thalidomide with or without dexamethasone for refractory or relapsing multiple myeloma.

    abstract::Both thalidomide and intermittent high-dose dexamethasone are agents with established activity against multiple myeloma. We summarized our experience with thalidomide alone, and then in combination with dexamethasone, for groups of patients with myeloma resistant or relapsing despite standard treatments. Criteria of r...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2003.09.006

    authors: Alexanian R,Weber D,Anagnostopoulos A,Delasalle K,Wang M,Rankin K

    更新日期:2003-10-01 00:00:00

  • Autologous hematopoietic cell transplantation for AML in first remission - An abandoned practice or promising approach?

    abstract::Patients with acute myeloid leukemia (AML) who achieve complete remission after induction therapy require post remission therapy (PRT) in order to remain disease free. The role of autologous hematopoietic cell transplantation (autoHCT) in the PRT setting is controversial and is largely based on older trials that were ...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2019.01.001

    authors: Yeshurun M,Wolach O

    更新日期:2019-04-01 00:00:00

  • Which Acute Myeloid Leukemia Patients Should Be Offered Transplantation?

    abstract::Acute myeloid leukemia (AML) is a heterogeneous disease characterized by multiple genetic and epigenetic alterations. The major causes of treatment failure remain disease relapse and treatment toxicity. However, major advances in biological determinants of disease relapse, development of targeted molecules, improvemen...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2015.03.001

    authors: Brissot E,Mohty M

    更新日期:2015-07-01 00:00:00

  • RUNX1 deficiency (familial platelet disorder with predisposition to myeloid leukemia, FPDMM).

    abstract::In this review, we discuss disease-causing alterations of RUNT-related transcription factor 1 (RUNX1), a master regulator of hematopoietic differentiation. Familial platelet disorder with predisposition to myeloid leukemia (FPDMM) typically presents with (1) mild to moderate thrombocytopenia with normal-sized platelet...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2017.04.006

    authors: Schlegelberger B,Heller PG

    更新日期:2017-04-01 00:00:00

  • The new direct oral anticoagulants in special indications: rationale and preliminary data in cancer, mechanical heart valves, anti-phospholipid syndrome, and heparin-induced thrombocytopenia and beyond.

    abstract::The present review will briefly summarize the interplay between coagulation and inflammation, highlighting possible effects of direct inhibition of factor Xa and thrombin beyond anticoagulation. Additionally, the rationale for the use of the new direct oral anticoagulants (DOACs) for indications such as cancer-associa...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2014.03.002

    authors: Alberio L

    更新日期:2014-04-01 00:00:00

  • Perspectives on familial chronic lymphocytic leukemia: genes and the environment.

    abstract::Chronic lymphocytic leukemia (CLL) comprises a substantial proportion of leukemias in adults in the western hemisphere. Male gender, increasing age, ethnicity (high in Caucasians, lowest in Asians), and family history are risk factors. Although no specific extrinsic etiologic factors have been established, farming and...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2004.05.002

    authors: Caporaso N,Marti GE,Goldin L

    更新日期:2004-07-01 00:00:00

  • Challenges to preventing infectious complications, decreasing re-hospitalizations, and reducing cost burden in long-term survivors after allogeneic hematopoietic stem cell transplantation.

    abstract::Even though the overall outcome after allogeneic transplant has improved significantly in the last decades, late infectious diseases are still the most important causes of late morbidity and mortality. Here, impaired immune reconstitution and therapy of chronic graft-versus-host disease (GVHD) represent the major risk...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:10.1053/j.seminhematol.2011.10.009

    authors: Fuji S,Kapp M,Einsele H

    更新日期:2012-01-01 00:00:00

  • Pharmacologic approaches to reversing multidrug resistance.

    abstract::The rationale for modulation of multidrug resistance (MDR) by inhibitors of the multidrug transporter, P-glycoprotein (P-gp) includes the following: (1) P-gp is expressed by human cancers, either at diagnosis or after failure of chemotherapy; (2) P-gp expression at diagnosis has been associated with a poor prognosis i...

    journal_title:Seminars in hematology

    pub_type: 杂志文章,评审

    doi:

    authors: Sikic BI

    更新日期:1997-10-01 00:00:00